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by Matt Lowrimore in NFL Picks
Week 12 of the NFL will conclude on Monday night with a game that will see the San Francisco 49ers take on the Carolina Panthers take on the Indianapolis Colts. Let’s take a look at the match statistics and predictions for this game between the 49ers and the Panthers.
Carolina enters this game with a record of 6-5, having most recently beaten the Atlanta Falcons in Week 11 by a score of 30-27. The Panthers’ offense had a total of 486 yards, while its defense allowed 348 yards. Quarterback Bryce Young threw for 448 yards and three touchdowns, while running back Rico Dowdle led the team in rushing with 45 yards.
As for San Francisco, they enter this game with a record of 7-4, having most recently beaten the Arizona Cardinals in Week 11 by a score of 41-22. The 49ers’ offense had a total of 281 yards, while its defense allowed 488 yards. Quarterback Brock Purdy threw for 200 yards and three touchdowns, while running back Christian McCaffrey led the team in rushing with 81 yards and three total touchdowns.
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Carolina Panthers vs San Francisco 49ers Form
Table
| Teams | % | P | W | D | L |
|---|---|---|---|---|---|
|
11
|
0.636 | 11 | 7 | 0 | 4 |
|
17
|
0.545 | 11 | 6 | 0 | 5 |
Carolina Panthers and San Francisco 49ers Latest Matches
4/6 (67%)
0/6 (0%)
2/6 (33%)
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4/6 (67%)
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3/6 (50%)
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3/6 (50%)
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2/6 (33%)
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4/6 (67%)
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4/6 (67%)
0/6 (0%)
2/6 (33%)
Nov 16, 2025 - NFL
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Carolina Panthers against San Francisco 49ers : Head to Head (H2H)
Oct 27, 2019 - NFL
Carolina Panthers - San Francisco 49ers Key Points
- The 49ers are averaging 23.7 points per game
- The 49ers are allowing 22.9 points per game
- The Panthers are averaging 18.8 points per game
- The Panthers are allowing 22.6 points per game
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Our Carolina Panthers vs San Francisco 49ers Prediction
The 49ers are the touchdown favorite in this game; however, the Panthers could be the best betting option. Carolina is coming off one of their best games offensively last week, where their quarterback, Bryce Young, had a career-high in passing yards.
The 49ers, on the other hand, have won three straight games, but are now facing a Panthers team that has slowly been improving. San Francisco has a lethal rushing attack with McCaffrey; however, they can sometimes be inconsistent in the passing game with Brock Purdy at quarterback. For that reason, our San Francisco 49ers vs Carolina Panthers prediction is: Carolina Panthers +7.5 Alternate Spread.Claim $200+ for your Carolina Panthers vs San Francisco 49ers wager!
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
