Atlanta Falcons vs San Francisco 49ers Prediction & Picks - NFL

USA - NFL

Atlanta Falcons
10/19/25 20:20
San Francisco 49ers

Prediction:

 

Atlanta Falcons +3.5 Alternate Spread

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 by Matt Lowrimore in NFL Picks

The Week 7 Sunday slate in the NFL will conclude on Sunday night with an NFC game between the Atlanta Falcons and the San Francisco 49ers. Let’s take a look at the match statistics and predictions for this game between the Falcons and the 49ers.

Atlanta enters this game with a record of 3-2, having most recently beaten the Buffalo Bills in Week 6 by a score of 24-14. The Falcons’ offense had a total of 443 yards, while its defense allowed 291 yards. Quarterback Michael Penix Jr. threw for 250 yards and one touchdown, while running back Bijan Robinson led the team in rushing with 170 yards and one touchdown.

As for San Francisco, they enter this game with a record of 4-2, having most recently lost to the Tampa Bay Buccaneers in Week 6 by a score of 30-19. The 49ers’ offense had a total of 363 yards, while its defense allowed 352 yards. Quarterback Mac Jones threw for 347 yards and two interceptions, while running back Christian McCaffrey led the team in rushing with 54 yards and one touchdown.

Atlanta Falcons vs San Francisco 49ers Form

Table

Teams % P W D L
7
San Francisco 49ers
San Francisco 49ers
0.667 6 4 0 2
15
Atlanta Falcons
Atlanta Falcons
0.6 5 3 0 2

Atlanta Falcons and San Francisco 49ers Latest Matches

Atlanta Falcons
Atlanta Falcons Latest matches
L L W L W W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 13, 2025 - NFL

Buffalo Bills
14 :  24
Atlanta Falcons

Sep 28, 2025 - NFL

Washington Commanders
27 :  34
Atlanta Falcons

Sep 21, 2025 - NFL

Atlanta Falcons
0 :  30
Carolina Panthers

Sep 14, 2025 - NFL

Atlanta Falcons
22 :  6
Minnesota Vikings

Sep 7, 2025 - NFL

Tampa Bay Buccaneers
23 :  20
Atlanta Falcons

Jan 5, 2025 - NFL

Carolina Panthers
44 :  38
Atlanta Falcons
L W L L W W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 13, 2025 - NFL

Buffalo Bills
14 :  24
Atlanta Falcons

Sep 28, 2025 - NFL

Washington Commanders
27 :  34
Atlanta Falcons

Sep 7, 2025 - NFL

Tampa Bay Buccaneers
23 :  20
Atlanta Falcons

Jan 5, 2025 - NFL

Carolina Panthers
44 :  38
Atlanta Falcons

Dec 22, 2024 - NFL

New York Giants
7 :  34
Atlanta Falcons

Dec 1, 2024 - NFL

Los Angeles Chargers
17 :  13
Atlanta Falcons
L L W L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 21, 2025 - NFL

Atlanta Falcons
0 :  30
Carolina Panthers

Sep 14, 2025 - NFL

Atlanta Falcons
22 :  6
Minnesota Vikings

Dec 29, 2024 - NFL

Atlanta Falcons
24 :  30
Washington Commanders

Dec 16, 2024 - NFL

Atlanta Falcons
15 :  9
Las Vegas Raiders

Dec 8, 2024 - NFL

Atlanta Falcons
21 :  42
Minnesota Vikings

Nov 17, 2024 - NFL

Atlanta Falcons
6 :  38
Denver Broncos
San Francisco 49ers
San Francisco 49ers Latest matches
W W W L W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 12, 2025 - NFL

San Francisco 49ers
19 :  30
Tampa Bay Buccaneers

Oct 2, 2025 - NFL

San Francisco 49ers
26 :  23
Los Angeles Rams

Sep 28, 2025 - NFL

Jacksonville Jaguars
26 :  21
San Francisco 49ers

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers

Sep 14, 2025 - NFL

San Francisco 49ers
26 :  21
New Orleans Saints

Sep 7, 2025 - NFL

San Francisco 49ers
17 :  13
Seattle Seahawks
L W L L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 28, 2025 - NFL

Jacksonville Jaguars
26 :  21
San Francisco 49ers

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers

Dec 30, 2024 - NFL

Detroit Lions
40 :  34
San Francisco 49ers

Dec 12, 2024 - NFL

Los Angeles Rams
12 :  6
San Francisco 49ers

Dec 8, 2024 - NFL

Chicago Bears
13 :  38
San Francisco 49ers

Nov 17, 2024 - NFL

Seattle Seahawks
20 :  17
San Francisco 49ers
L L W W W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 12, 2025 - NFL

San Francisco 49ers
19 :  30
Tampa Bay Buccaneers

Oct 2, 2025 - NFL

San Francisco 49ers
26 :  23
Los Angeles Rams

Sep 14, 2025 - NFL

San Francisco 49ers
26 :  21
New Orleans Saints

Sep 7, 2025 - NFL

San Francisco 49ers
17 :  13
Seattle Seahawks

Jan 5, 2025 - NFL

San Francisco 49ers
24 :  47
Arizona Cardinals

Dec 22, 2024 - NFL

San Francisco 49ers
17 :  29
Miami Dolphins

Atlanta Falcons - San Francisco 49ers Key Points

  1. Atlanta is 3-2 ATS this season
  2. Atlanta is averaging 20.0 points per game this season
  3. San Francisco is 3-3 ATS this season
  4. San Francisco is averaging 20.8 points per game this season

Our Atlanta Falcons vs San Francisco 49ers Prediction

Atlanta may be a small underdog in this matchup with San Francisco, but still look to be the best betting option given their recent performances. The Falcons are coming off a huge win against the Bills, where running back Bijan Robinson had 238 scrimmage yards. Atlanta has now won each of their last two games by an average of 8.5 points per game. 

San Francisco, on the other hand, has lost two of their last three games. During this stretch, the 49ers have been a little inconsistent, averaging 22 points per game. Therefore, given that the Falcons are starting to become a real threat in the NFL, our San Francisco 49ers vs Atlanta Falcons prediction is: Atlanta Falcons +3.5 Alternate Spread.

Prediction:

 

Atlanta Falcons +3.5 Alternate Spread

-159
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Atlanta Falcons vs San Francisco 49ers Picks