Los Angeles Chargers vs Indianapolis Colts Prediction & Picks - NFL

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Los Angeles Chargers
10/19/25 16:05
Indianapolis Colts

Prediction:

 

Indianapolis +1.5

-110
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 by Bill Christy | in NFL Picks

One of the best games forecasted for this weekend will take place during the later portion of Sunday when the Los Angeles Chargers (4-2) host the Indianapolis Colts (5-1). Daniel Jones has found a home in Indy after coming from the Giants where he never looked comfortable. Now, he is playing like an early MVP candidate and leading this Colts offense that leads the NFL in scoring with 32.3 points per game. Not to be outdone, the defense is holding its own as well and holding opponents to just 19.3 points per game which is 4th best in the NFL. The offense is going to be truly tested this weekend when they face a Charger defense that is 12th in the NFL and allowing just 20.8 points per game. Both teams are getting it done through the air and are currently ranked #6 and #7 in passing offense. Not many would have thought a Daniel Jones versus Justin Herbert matchup would be one that many would have been excited to see coming off last season, but here we are. Will the Chargers be able to slow down this high-powered Colts offense, or will the Colts defense stifle Herbert and company enough to allow the offense to take a week off? Time will tell in what should be an entertaining late slate game this Sunday.

Los Angeles Chargers vs Indianapolis Colts Form

Table

Teams Pts P W L
9 Los Angeles Chargers
0.647 17 11 6
20 Indianapolis Colts
0.471 17 8 9

Los Angeles Chargers and Indianapolis Colts Latest Matches

Los Angeles Chargers
Los Angeles Chargers Latest matches
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 12, 2025 - NFL

Miami Dolphins
27 :  29
Los Angeles Chargers

Oct 5, 2025 - NFL

Los Angeles Chargers
10 :  27
Washington Commanders

Sep 28, 2025 - NFL

New York Giants
21 :  18
Los Angeles Chargers

Sep 21, 2025 - NFL

Los Angeles Chargers
23 :  20
Denver Broncos

Sep 15, 2025 - NFL

Las Vegas Raiders
9 :  20
Los Angeles Chargers

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 5, 2025 - NFL

Los Angeles Chargers
10 :  27
Washington Commanders

Sep 21, 2025 - NFL

Los Angeles Chargers
23 :  20
Denver Broncos

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs

Dec 19, 2024 - NFL

Los Angeles Chargers
34 :  27
Denver Broncos

Dec 15, 2024 - NFL

Los Angeles Chargers
17 :  40
Tampa Bay Buccaneers

Nov 25, 2024 - NFL

Los Angeles Chargers
23 :  30
Baltimore Ravens
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 12, 2025 - NFL

Miami Dolphins
27 :  29
Los Angeles Chargers

Sep 28, 2025 - NFL

New York Giants
21 :  18
Los Angeles Chargers

Sep 15, 2025 - NFL

Las Vegas Raiders
9 :  20
Los Angeles Chargers

Jan 11, 2025 - NFL

Houston Texans
32 :  12
Los Angeles Chargers

Jan 5, 2025 - NFL

Las Vegas Raiders
20 :  34
Los Angeles Chargers

Dec 28, 2024 - NFL

New England Patriots
7 :  40
Los Angeles Chargers
Indianapolis Colts
Indianapolis Colts Latest matches
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 12, 2025 - NFL

Indianapolis Colts
31 :  27
Arizona Cardinals

Oct 5, 2025 - NFL

Indianapolis Colts
40 :  6
Las Vegas Raiders

Sep 28, 2025 - NFL

Los Angeles Rams
27 :  20
Indianapolis Colts

Sep 21, 2025 - NFL

Tennessee Titans
20 :  41
Indianapolis Colts

Sep 14, 2025 - NFL

Indianapolis Colts
29 :  28
Denver Broncos

Sep 7, 2025 - NFL

Indianapolis Colts
33 :  8
Miami Dolphins
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Oct 12, 2025 - NFL

Indianapolis Colts
31 :  27
Arizona Cardinals

Oct 5, 2025 - NFL

Indianapolis Colts
40 :  6
Las Vegas Raiders

Sep 14, 2025 - NFL

Indianapolis Colts
29 :  28
Denver Broncos

Sep 7, 2025 - NFL

Indianapolis Colts
33 :  8
Miami Dolphins

Jan 5, 2025 - NFL

Indianapolis Colts
26 :  23
Jacksonville Jaguars

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 28, 2025 - NFL

Los Angeles Rams
27 :  20
Indianapolis Colts

Sep 21, 2025 - NFL

Tennessee Titans
20 :  41
Indianapolis Colts

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 15, 2024 - NFL

Denver Broncos
31 :  13
Indianapolis Colts

Dec 1, 2024 - NFL

New England Patriots
24 :  25
Indianapolis Colts

Nov 17, 2024 - NFL

New York Jets
27 :  28
Indianapolis Colts

Los Angeles Chargers against Indianapolis Colts : Head to Head (H2H)

Los Angeles Chargers

100 %

Indianapolis Colts

0 %

Dec 26, 2022 - NFL

Indianapolis Colts
3 :  20
Los Angeles Chargers

Los Angeles Chargers - Indianapolis Colts Key Points

  1. Indianapolis is 6-1 SU in its last 7 games.
  2. Indianapolis is 8-3 SU in its last 11 games played on a Sunday.
  3. Indianapolis is 9-3 ATS in its last 12 games played in week 7.
  4. Los Angeles is 1-5 ATS in its last 6 games played in week 7.

Our Los Angeles Chargers vs Indianapolis Colts Prediction

Both offenses could put up points and while the total is tempting to take, we are going to shy away and back what we believe is the most complete team currently in the NFL. The Colts’ defense has looked good but is the ability of the offense to dominate through the air or on the ground that has been most impressive. We believe they are going to take whatever the Chargers give them this weekend. If they take away the passing game, watch for Jonathan Taylor to have a big game on the ground. Either way, the Colts will get it done once again here.

Prediction:

 

Indianapolis +1.5

-110
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Los Angeles Chargers vs Indianapolis Colts Picks