Tennessee Titans vs New England Patriots Prediction & Picks - NFL

Prediction published on 10/19/25, 9:43 AM  by Bill Christy | Modified on 1/16/26 at 5:01 AM in NFL Picks

The Tennessee Titans (1-5) will play hosts to the New England Patriots (4-2) this Sunday inside Nissan Stadium. The Titans ended a 4-game losing streak just two weeks ago with a win over the Arizona Cardinals (22-21), but failed to make it two in a row when they lost on the road to the Raiders last week (20-10). Offensively, the Titans have been putrid and rookie QB, Cam Ward has not been able to find a rhythm. During last week, he lost his top receiver in Calvin Ridley who is dealing with an injury that could keep him out of this matchup with the Patriots. This past week, the leadership decided to part ways with head coach Brian Callahan, which could motivate this team to begin playing like their jobs depend on it. Conversely, the Patriots have been playing their best ball as of late. After a 1-2 start to the season, this team has won 3 straight games and have been averaging 33.3 points per game during that stretch. Drake Maye has tossed 10 touchdowns and just 2 interceptions to date and has begun to look like the franchise QB that all New England had been hoping for.  Head Coach Mike Vrabel is enjoying his time back in New England where he won multiple Super Bowls as a player and now gets a chance to take some hostility out on the franchise that let him go as a coach just a few seasons back.