USC Trojans vs Oregon Ducks Prediction & Picks - NCAA
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by Matt Lowrimore | in NCAA Picks
One of the best games on the Week 4 College Football Saturday slate will feature a Big Ten matchup between the 20th-ranked Oregon Ducks and the 12th-ranked USC Trojans. Let’s take a look at the match statistics and predictions for this game between the Oregon Ducks and the USC Trojans.
Oregon enters this game with a record of 2-1, and this will be their first Big Ten game of the season. The Ducks bounced back from a disappointing Week 2 loss to Oklahoma State by beating Portland State in Week 3 by a score of 84-0. Oregon had 726 yards of offense in this game, while allowing 103 yards. That said, the Ducks have already shown their cracks against the real opponents they have played this season.
As for USC, they enter this game with a record of 4-0 and are 1-0 in the Big Ten. The Trojans are coming off a 42-35 win in Week 3 against Rutgers, where they had 461 yards of offense. That said, their defense allowed 460 yards to Rutgers and continues to be inconsistent this season.
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USC Trojans vs Oregon Ducks Form
Table
USC Trojans and Oregon Ducks Latest Matches
5/6 (83%)
1/6 (17%)
Sep 19, 2026 - NCAA
Sep 12, 2026 - NCAA
Sep 4, 2026 - NCAA
Aug 29, 2026 - NCAA
Dec 30, 2025 - NCAA Division I, FBS, Playoffs
Nov 29, 2025 - NCAA
6/6 (100%)
0/6 (0%)
Sep 12, 2026 - NCAA
Sep 4, 2026 - NCAA
Aug 29, 2026 - NCAA
Nov 29, 2025 - NCAA
Nov 15, 2025 - NCAA
Nov 7, 2025 - NCAA
2/6 (33%)
4/6 (67%)
Sep 19, 2026 - NCAA
Dec 30, 2025 - NCAA Division I, FBS, Playoffs
Nov 22, 2025 - NCAA
Nov 1, 2025 - NCAA
Oct 18, 2025 - NCAA
Sep 27, 2025 - NCAA
4/6 (67%)
2/6 (33%)
Sep 18, 2026 - NCAA
Sep 12, 2026 - NCAA
Sep 5, 2026 - NCAA
Jan 9, 2026 - NCAA
Jan 1, 2026 - NCAA
Dec 20, 2025 - NCAA
6/6 (100%)
0/6 (0%)
Sep 18, 2026 - NCAA
Sep 5, 2026 - NCAA
Dec 20, 2025 - NCAA
Nov 22, 2025 - NCAA
Nov 14, 2025 - NCAA
Oct 25, 2025 - NCAA
4/6 (67%)
2/6 (33%)
Sep 12, 2026 - NCAA
Jan 9, 2026 - NCAA
Jan 1, 2026 - NCAA
Nov 29, 2025 - NCAA
Nov 8, 2025 - NCAA
Oct 18, 2025 - NCAA
USC Trojans against Oregon Ducks : Head to Head (H2H)
0 %
100 %
Nov 22, 2025 - NCAA
USC Trojans - Oregon Ducks Key Points
- Oregon is 0-1 SU on the road this season
- Oregon is 0-1 ATS on the road this season
- USC is 3-0 SU at home this season
- USC is averaging 43.0 points per game this season
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Our USC Trojans vs Oregon Ducks Prediction
Oregon is the small favorite in this game; however, USC looks to be the best betting option. While the Trojans have had their issues defensively, their offense has been one of the best units in the country. As it stands, USC is averaging 43.0 points per game.
Oregon, on the other hand, has overall not been consistent this season. The 80+ point win against Portland State in Week 3 hardly counts as impressive, and simply put, the Ducks were lucky to sneak away with a win against Boise State in Week 1.
Given this, our Oregon Ducks vs. USC Trojans prediction is: USC Trojans +3.5 Alternate Spread.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
