Los Angeles Chargers vs New York Giants Prediction & Picks - NFL

USA - NFL

Los Angeles Chargers
9/28/25 13:00
New York Giants

Prediction:

 

Chargers -6.5 points

-106
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 by Lou Aguila | in NFL Picks

The Los Angeles Chargers will take their immaculate 3-0 record into Sunday's week 4 clash with the New York Giants at MetLife Stadium.

The Chargers, 4-0 in their last four meetings with the Giants, are listed as -290 favorites and -106 on a -6.5-point handicap.

Current Form:

The Chargers roar into week 4 still undefeated after topping the Kansas City Chiefs 27-21, the Las Vegas Raiders 20-9, and the Denver Broncos 23-20. With quarterback Justin Herbert off to an explosive start, Los Angeles is averaging 270 passing yards per game (2nd in the NFL) and 23.3 points per game (14th). The Chargers’ defense is also elite, yielding an average of 16.7 points allowed per game (3rd in the NFL).

The Giants have gone 0-3 in their first three games this season. New York lost to the Washington Commanders 6-21 before absorbing a tough overtime loss to the Dallas Cowboys 37-40 in Week 2. In the third week, the Giants got manhandled by the Kansas City Chiefs 9-22 last week.

Quarterback Matchup:

Chargers quarterback Justin Herbert (860 yards with six TDs and one interception) vs. Giants quarterback Russell Wilson (778 yards with three TDs and three interceptions).

Los Angeles Chargers vs New York Giants Form

Table

Teams % P W D L
8
Los Angeles Chargers
Los Angeles Chargers
0.667 6 4 0 2
24
New York Giants
New York Giants
0.333 6 2 0 4

Los Angeles Chargers and New York Giants Latest Matches

Los Angeles Chargers
Los Angeles Chargers Latest matches
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 21, 2025 - NFL

Denver Broncos
20 :  23
Los Angeles Chargers

Sep 15, 2025 - NFL

Los Angeles Chargers
20 :  9
Las Vegas Raiders

Sep 5, 2025 - NFL

Kansas City Chiefs
21 :  27
Los Angeles Chargers

Jan 11, 2025 - NFL

Los Angeles Chargers
12 :  32
Houston Texans

Jan 5, 2025 - NFL

Los Angeles Chargers
34 :  20
Las Vegas Raiders

Dec 28, 2024 - NFL

Los Angeles Chargers
40 :  7
New England Patriots
W L L W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 21, 2025 - NFL

Denver Broncos
20 :  23
Los Angeles Chargers

Sep 5, 2025 - NFL

Kansas City Chiefs
21 :  27
Los Angeles Chargers

Dec 19, 2024 - NFL

Denver Broncos
27 :  34
Los Angeles Chargers

Dec 15, 2024 - NFL

Tampa Bay Buccaneers
40 :  17
Los Angeles Chargers

Nov 25, 2024 - NFL

Baltimore Ravens
30 :  23
Los Angeles Chargers

Nov 17, 2024 - NFL

Cincinnati Bengals
27 :  34
Los Angeles Chargers
W L W W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 15, 2025 - NFL

Los Angeles Chargers
20 :  9
Las Vegas Raiders

Jan 11, 2025 - NFL

Los Angeles Chargers
12 :  32
Houston Texans

Jan 5, 2025 - NFL

Los Angeles Chargers
34 :  20
Las Vegas Raiders

Dec 28, 2024 - NFL

Los Angeles Chargers
40 :  7
New England Patriots

Dec 8, 2024 - NFL

Los Angeles Chargers
17 :  19
Kansas City Chiefs

Dec 1, 2024 - NFL

Los Angeles Chargers
17 :  13
Atlanta Falcons
New York Giants
New York Giants Latest matches
L W L L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 21, 2025 - NFL

Kansas City Chiefs
22 :  9
New York Giants

Sep 14, 2025 - NFL

New York Giants
37 :  40
Dallas Cowboys

Sep 7, 2025 - NFL

New York Giants
6 :  21
Washington Commanders

Jan 5, 2025 - NFL

New York Giants
13 :  20
Philadelphia Eagles

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 22, 2024 - NFL

New York Giants
7 :  34
Atlanta Falcons
L L L L W L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 21, 2025 - NFL

Kansas City Chiefs
22 :  9
New York Giants

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 15, 2024 - NFL

Baltimore Ravens
35 :  14
New York Giants

Dec 8, 2024 - NFL

New Orleans Saints
14 :  11
New York Giants

Nov 24, 2024 - NFL

Tampa Bay Buccaneers
30 :  7
New York Giants

Nov 3, 2024 - NFL

Washington Commanders
27 :  22
New York Giants
L L L L L L
Victories

0/6 (0%)

Draw

0/6 (0%)

Defeats

6/6 (100%)

Sep 14, 2025 - NFL

New York Giants
37 :  40
Dallas Cowboys

Sep 7, 2025 - NFL

New York Giants
6 :  21
Washington Commanders

Jan 5, 2025 - NFL

New York Giants
13 :  20
Philadelphia Eagles

Dec 22, 2024 - NFL

New York Giants
7 :  34
Atlanta Falcons

Nov 28, 2024 - NFL

New York Giants
20 :  27
Dallas Cowboys

Nov 10, 2024 - NFL

New York Giants
17 :  20
Carolina Panthers

Los Angeles Chargers - New York Giants Key Points

  1. NY Giants is 1-9 SU in its last 10 games at home.
  2. NY Giants is 3-12 ATS in its last 15 games.
  3. LA Chargers is 6-1 ATS in its last 7 games.
  4. LA Chargers is 5-0 ATS in its last 5 games against NY Giants.

Our Los Angeles Chargers vs New York Giants Prediction

Chargers quarterback Justin Herbert (860 yards with six TDs and one interception) vs. Giants quarterback Russell Wilson (778 yards with three TDs and three interceptions).

The Chargers are in a position to make another statement win on the road against the Giants. In their last four inter-conference meetings, Los Angeles has gone 4-0 against New York. They are also 4-1 against the spread in their last five road games, proving that this team thrives even in a hostile environment.

If the Giants want to score an upset over the Chargers, they must first contain quarterback Justin Herbert, who has already amassed 860 passing yards with 6 TDs. Although he has already been sacked 10 times this season, Herbert has been tough as nails as he continues to torch opponents with his passing.

The Giants hope their quarterback, Russell Wilson, can turn back the hands of time and deliver a vintage performance on Sunday. However, Wilson and the offensive line will need to step up their game because they are facing a Chargers team that ranks 9th in the league against the pass (182.0 passing yards allowed per game).

Fearless Forecast: Charges 40, Giants 22

Our betting prediction for the Los Angeles Charges vs. the New York Giants: the Chargers -6.5 points

Prediction:

 

Chargers -6.5 points

-106
$300+ offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Los Angeles Chargers vs New York Giants Picks