Carolina Panthers vs Seattle Seahawks Prediction & Picks - NFL

Prediction published on 12/28/25, 9:19 AM  by Carlos Zabala | Modified on 1/16/26 at 4:44 AM in NFL Picks

The Panthers are coming off their most crucial win of the season, a 23-20 victory over the Buccaneers at Bank of America Stadium in Week 16, which knocked them out of first place in the division. This week, the Panthers will face the Bucs again, this time in Tampa, in a high-stakes matchup. But first, they face the challenge of hosting the conference-leading 12-3 Seahawks. Betting sites favor Seattle by 7 points in pregame odds.

The Panthers capitalized on a Lathan Ransom interception of Baker Mayfield that ended Tampa's final drive. In the win, Ryce Young threw two touchdown passes, but far from getting too carried away, the Carolina quarterback emphasized that the next game against Seattle is the most important of all.

The Seahawks, already in the playoffs, will look to secure their sixth consecutive victory in Charlotte. So far, the Titans, Vikings, Colts, and Rams have been their victims. Their latest victory was their most valuable, a 38-37 win over Los Angeles. Rashid Shaheed returned a punt 58 yards for a touchdown. This ignited the Seahawks' comeback, as they scored 16 points in the fourth quarter and won overtime 8-7.