San Francisco 49ers vs Chicago Bears Prediction & Picks - NFL

USA - NFL

San Francisco 49ers
12/28/25 20:20
Chicago Bears

Prediction:

 

San Francisco -3

-110
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 by Bill Christy | in NFL Picks

Two of the top teams in the NFC will collide on Sunday Night at Levi’s Stadium. The San Francisco 49ers (11-4) will host the Chicago Bears (11-4). Both teams are fighting to improve their spot in the NFC standings for the playoffs. Chicago also has the best chance at securing their division as well.

San Francisco is on a 5-game winning streak and coming off a 48-27 win over the Colts, in which Brock Purdy looked to be in the best form of the season. He finished with 295 passing yards, completed 73.5% of his passes, and tossed 5 touchdowns. Christian McCaffery chimed in with 117 yards on the ground and scored twice on catches from Purdy. This 49er team is one of the most complete teams in the NFC and has an offense scoring inside the top 10, while their defense is just outside at 11th in points allowed per game.

Chicago has been the surprise of the season. They are currently in 2nd place in the entire conference and have won 7 of their last 8 games. Their most recent win came over their division rivals, the Green Bay Packers. The Chicago offense was humming and finished with 400 total yards. On the season, Caleb Williams has not been all that impressive. However, he is not turning the ball over, which is all the offense has really needed.

This game should play like a playoff game due to all the implications it holds. And on paper, the matchup is as even as possible. Miscues and/or turnovers will play big roles in this matchup which could be an NFC Championship Game preview

San Francisco 49ers vs Chicago Bears Form

Table

Teams Pts P W L
7 San Francisco 49ers
0.706 17 12 5
11 Chicago Bears
0.647 17 11 6

San Francisco 49ers and Chicago Bears Latest Matches

San Francisco 49ers
San Francisco 49ers Latest matches
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 22, 2025 - NFL

Indianapolis Colts
27 :  48
San Francisco 49ers

Dec 14, 2025 - NFL

San Francisco 49ers
37 :  24
Tennessee Titans

Nov 30, 2025 - NFL

Cleveland Browns
8 :  26
San Francisco 49ers

Nov 24, 2025 - NFL

San Francisco 49ers
20 :  9
Carolina Panthers

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Nov 9, 2025 - NFL

San Francisco 49ers
26 :  42
Los Angeles Rams
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 14, 2025 - NFL

San Francisco 49ers
37 :  24
Tennessee Titans

Nov 24, 2025 - NFL

San Francisco 49ers
20 :  9
Carolina Panthers

Nov 9, 2025 - NFL

San Francisco 49ers
26 :  42
Los Angeles Rams

Oct 19, 2025 - NFL

San Francisco 49ers
20 :  10
Atlanta Falcons

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 22, 2025 - NFL

Indianapolis Colts
27 :  48
San Francisco 49ers

Nov 30, 2025 - NFL

Cleveland Browns
8 :  26
San Francisco 49ers

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Nov 2, 2025 - NFL

New York Giants
24 :  34
San Francisco 49ers

Oct 26, 2025 - NFL

Houston Texans
26 :  15
San Francisco 49ers

Oct 12, 2025 - NFL

Tampa Bay Buccaneers
30 :  19
San Francisco 49ers
Chicago Bears
Chicago Bears Latest matches
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 20, 2025 - NFL

Chicago Bears
22 :  16
Green Bay Packers

Dec 14, 2025 - NFL

Chicago Bears
31 :  3
Cleveland Browns

Dec 7, 2025 - NFL

Green Bay Packers
28 :  21
Chicago Bears

Nov 28, 2025 - NFL

Philadelphia Eagles
15 :  24
Chicago Bears

Nov 23, 2025 - NFL

Chicago Bears
31 :  28
Pittsburgh Steelers

Nov 16, 2025 - NFL

Minnesota Vikings
17 :  19
Chicago Bears
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Dec 20, 2025 - NFL

Chicago Bears
22 :  16
Green Bay Packers

Dec 14, 2025 - NFL

Chicago Bears
31 :  3
Cleveland Browns

Nov 23, 2025 - NFL

Chicago Bears
31 :  28
Pittsburgh Steelers

Nov 9, 2025 - NFL

Chicago Bears
24 :  20
New York Giants

Oct 19, 2025 - NFL

Chicago Bears
26 :  14
New Orleans Saints

Sep 21, 2025 - NFL

Chicago Bears
31 :  14
Dallas Cowboys
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 7, 2025 - NFL

Green Bay Packers
28 :  21
Chicago Bears

Nov 28, 2025 - NFL

Philadelphia Eagles
15 :  24
Chicago Bears

Nov 16, 2025 - NFL

Minnesota Vikings
17 :  19
Chicago Bears

Nov 2, 2025 - NFL

Cincinnati Bengals
42 :  47
Chicago Bears

Oct 26, 2025 - NFL

Baltimore Ravens
30 :  16
Chicago Bears

Oct 13, 2025 - NFL

Washington Commanders
24 :  25
Chicago Bears

San Francisco 49ers against Chicago Bears : Head to Head (H2H)

San Francisco 49ers

100 %

Chicago Bears

0 %

Dec 8, 2024 - NFL

San Francisco 49ers
38 :  13
Chicago Bears

Oct 31, 2021 - NFL

Chicago Bears
22 :  33
San Francisco 49ers
San Francisco 49ers vs Chicago Bears Picks

San Francisco 49ers - Chicago Bears Key Points

  1. Chicago is 9-24-1 ATS in its last 34 games played on a Sunday when playing on the road.
  2. Chicago is 2-9 ATS in its last 11 games when playing on the road against San Francisco.
  3. San Francisco is 6-1 ATS in its last 7 games.
  4. San Francisco is 6-0 ATS in its last 6 games when playing as the favorite.

Our San Francisco 49ers vs Chicago Bears Prediction

The public is finally buying into this Chicago team. 60% of their tickets are currently on the Bears, and we will be happy to fade them in this spot. Last week, we saw Purdy and company finally put everything together on offense. While this Bears defense is certainly better than the Colts', the total is over 50 points. Both offenses should shine, but we are going to back the one we feel is much hotter now.

Our prediction for San Francisco 49ers vs Chicago Bears: San Francisco -3

Prediction:

 

San Francisco -3

-110
$150 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.