Indianapolis Colts vs Tennessee Titans Prediction & Picks - NFL

Prediction published on 10/16/26, 1:00 PM  by Matt Lowrimore | Modified on 10/16/26 at 4:31 PM in NFL Picks

Another one of the games on the Week 6 NFL Sunday slate will feature an AFC South Division matchup between the Indianapolis Colts and the Tennessee Titans. Let’s take a look at the match statistics and predictions for this game between the Colts and the Titans.

Tennessee enters this game with a record of 0-5. The Titans' most recent setback was against the Houston Texans in Week 5, as they were crushed by a score of 26-3. Tennessee managed just 187 yards of offense in this game, while allowing 329 yards. At this point in the season, the Titans are starting to look like the worst team in the league. They have shown little to no confidence that they can put together four good quarters, a trend that looks likely to continue this week as well.

As for Indianapolis, they enter this game with a record of 2-3. The Colts are coming off a loss to the Pittsburgh Steelers in Week 5, a game they lost by a score of 34-22. Indianapolis managed to total 332 yards of offense, but allowed 352 yards. Further, Indianapolis was unable to convert in the red zone on multiple occasions, plus their defense was unable to make enough stops. Despite that, we should see the Colts have more success offensively in this game against the Titans.