Las Vegas Raiders vs Buffalo Bills Prediction & Picks - NFL

Prediction published on 10/16/26, 4:25 PM  by Matt Lowrimore | Modified on 10/16/26 at 4:33 PM in NFL Picks

Another one of the interesting games on the Week 6 Sunday NFL slate will see the Las Vegas Raiders take on the Buffalo Bills. Let’s take a look at the match statistics and predictions for this game between the Raiders and the Bills.

Buffalo enters this game with a record of 4-1 and is coming off a 37-34 overtime win against the Los Angeles Rams in Week 5. The Bills had 436 yards of offense in the game, while allowing 454 yards. Despite their defense having struggled, the Bills’ offense looks to be too strong for a Raiders’ defense that has allowed far too many points.

As for Las Vegas, they enter this game with a record of 3-2. The Raiders started this season strong, but are coming off back-to-back losses, the most recent being a 45-17 loss to the New England Patriots in Week 5. Las Vegas had 306 yards of offense in this game, but allowed 536 yards, which looks likely to be the main concern against a potent Buffalo offense.