Tennessee Titans vs Arizona Cardinals Prediction & Picks - NFL

USA - NFL

Tennessee Titans
10/5/25 16:05
Arizona Cardinals

Prediction:

 

Arizona Cardinals -6.5 Alternate Spread

-141
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 by Matt Lowrimore in NFL Picks

Another one of the games on the Week 5 NFL Sunday slate will see the Arizona Cardinals take on the Tennessee Titans. Let’s take a look at the match statistics and predictions for this game between the Cardinals and the Titans.

Tennessee enters this game with a record of 0-4, having most recently lost to the Houston Texans in Week 4 by a score of 26-0. The Titans’ offense had a total of 175 yards, while its defense allowed 353 yards. Quarterback Cam Ward threw for 108 yards and one interception, while running back Tony Pollard led the team in rushing with 64 yards.

As for Arizona, they enter this game with a record of 2-2, having most recently lost to the Seattle Seahawks in Week 4 by a score of 23-20. The Cardinals’ offense had a total of 253 yards, while its defense allowed 384 yards. Quarterback Kyler Murray threw for 200 yards, two touchdowns, and two interceptions, while also leading the team in rushing with 41 yards.

Tennessee Titans vs Arizona Cardinals Form

Table

Teams % P W D L
21
Arizona Cardinals
Arizona Cardinals
0.5 4 2 0 2
32
Tennessee Titans
Tennessee Titans
0 4 0 0 4

Tennessee Titans and Arizona Cardinals Latest Matches

Tennessee Titans
Tennessee Titans Latest matches
L L L L L L
Victories

0/6 (0%)

Draw

0/6 (0%)

Defeats

6/6 (100%)

Sep 28, 2025 - NFL

Tennessee Titans
0 :  26
Houston Texans

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Sep 14, 2025 - NFL

Los Angeles Rams
33 :  19
Tennessee Titans

Sep 7, 2025 - NFL

Tennessee Titans
12 :  20
Denver Broncos

Jan 5, 2025 - NFL

Houston Texans
23 :  14
Tennessee Titans

Dec 29, 2024 - NFL

Tennessee Titans
13 :  20
Jacksonville Jaguars
L L L L L L
Victories

0/6 (0%)

Draw

0/6 (0%)

Defeats

6/6 (100%)

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Sep 14, 2025 - NFL

Los Angeles Rams
33 :  19
Tennessee Titans

Jan 5, 2025 - NFL

Houston Texans
23 :  14
Tennessee Titans

Dec 15, 2024 - NFL

Cincinnati Bengals
37 :  27
Tennessee Titans

Dec 8, 2024 - NFL

Jacksonville Jaguars
10 :  6
Tennessee Titans

Nov 17, 2024 - NFL

Minnesota Vikings
23 :  13
Tennessee Titans
W L L L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 28, 2025 - NFL

Tennessee Titans
0 :  26
Houston Texans

Sep 7, 2025 - NFL

Tennessee Titans
12 :  20
Denver Broncos

Dec 29, 2024 - NFL

Tennessee Titans
13 :  20
Jacksonville Jaguars

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts

Dec 1, 2024 - NFL

Tennessee Titans
19 :  42
Washington Commanders

Nov 24, 2024 - NFL

Tennessee Titans
32 :  27
Houston Texans
Arizona Cardinals
Arizona Cardinals Latest matches
L W W W L L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 25, 2025 - NFL

Seattle Seahawks
23 :  20
Arizona Cardinals

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers

Sep 14, 2025 - NFL

Carolina Panthers
22 :  27
Arizona Cardinals

Sep 7, 2025 - NFL

Arizona Cardinals
20 :  13
New Orleans Saints

Jan 5, 2025 - NFL

San Francisco 49ers
24 :  47
Arizona Cardinals

Dec 28, 2024 - NFL

Arizona Cardinals
9 :  13
Los Angeles Rams
W L W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 25, 2025 - NFL

Seattle Seahawks
23 :  20
Arizona Cardinals

Sep 14, 2025 - NFL

Carolina Panthers
22 :  27
Arizona Cardinals

Jan 5, 2025 - NFL

San Francisco 49ers
24 :  47
Arizona Cardinals

Dec 15, 2024 - NFL

New England Patriots
17 :  30
Arizona Cardinals

Dec 8, 2024 - NFL

Seattle Seahawks
30 :  18
Arizona Cardinals

Nov 10, 2024 - NFL

New York Jets
6 :  31
Arizona Cardinals
L L L L W L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers

Sep 7, 2025 - NFL

Arizona Cardinals
20 :  13
New Orleans Saints

Dec 28, 2024 - NFL

Arizona Cardinals
9 :  13
Los Angeles Rams

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Dec 1, 2024 - NFL

Arizona Cardinals
22 :  23
Minnesota Vikings

Nov 24, 2024 - NFL

Arizona Cardinals
6 :  16
Seattle Seahawks

Tennessee Titans - Arizona Cardinals Key Points

  1. The Titans are 0-4 ATS this season
  2. The Cardinals are 1-3 ATS this season
  3. The Titans are averaging 12.8 points per game this season
  4. The Cardinals are averaging 20.5 points per game this season

Our Tennessee Titans vs Arizona Cardinals Prediction

Arizona has certainly not been impressive this season, but they have won a couple of games and has been competitive for the most part. As for Tennessee, they have been dreadful this season, and do not look as if they will improve anytime soon.

The Titans are averaging just 12.8 points per game, by far the fewest in the NFL. Further, the Titans were recently shut out against the Houston Texans in Week 4. The Titans are simply not a team that can be trusted to keep their games close; therefore, our Arizona Cardinals vs Tennessee Titans prediction is: Arizona Cardinals -6.5 Alternate Spread.

Prediction:

 

Arizona Cardinals -6.5 Alternate Spread

-141
$200 offered for betting!

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Tennessee Titans vs Arizona Cardinals Picks