USA - NFL
New customers only | Commercial content | 21+ age limit | T&Cs apply
The 4-1 San Francisco 49ers visit the 4-1 Tampa Bay Buccaneers in one of the standout Week 6 fixtures in the NFL.
The Bucs recorded a thrilling 38-35 win in Seattle last week, thanks to another MVP calible game from QB Baker Mayfield and a late field goal from the in-form Chase McLaughlin. That victory was Tampa's fourth one-score success of the campaign and means they have already opened up a two game lead in the NFC South standings.
San Francisco were also on the right end of a Week 5 thriller, as an overtime FG from Eddy Pineiro gave them a precious divisional victory over the LA Rams. Amazingly, like the Bucs, all of the Niners four wins this season have been in one-score contests.
Limited Offer. Currently at Caesars Sportsbook
San Francisco 49ers vs Tampa Bay Buccaneers Form
Table
| Teams | % | P | W | D | L |
|---|---|---|---|---|---|
|
2
|
0.8 | 5 | 4 | 0 | 1 |
|
3
|
0.8 | 5 | 4 | 0 | 1 |
San Francisco 49ers and Tampa Bay Buccaneers Latest Matches
4/6 (67%)
0/6 (0%)
2/6 (33%)
Oct 2, 2025 - NFL
Sep 28, 2025 - NFL
Sep 21, 2025 - NFL
Sep 14, 2025 - NFL
Sep 7, 2025 - NFL
Jan 5, 2025 - NFL
2/6 (33%)
0/6 (0%)
4/6 (67%)
Sep 28, 2025 - NFL
Sep 21, 2025 - NFL
Dec 30, 2024 - NFL
Dec 12, 2024 - NFL
Dec 8, 2024 - NFL
Nov 17, 2024 - NFL
3/6 (50%)
0/6 (0%)
3/6 (50%)
Oct 2, 2025 - NFL
Sep 14, 2025 - NFL
Sep 7, 2025 - NFL
Jan 5, 2025 - NFL
Dec 22, 2024 - NFL
Dec 1, 2024 - NFL
4/6 (67%)
0/6 (0%)
2/6 (33%)
Oct 5, 2025 - NFL
Sep 28, 2025 - NFL
Sep 21, 2025 - NFL
Sep 15, 2025 - NFL
Sep 7, 2025 - NFL
Jan 12, 2025 - NFL
4/6 (67%)
0/6 (0%)
2/6 (33%)
Sep 28, 2025 - NFL
Sep 21, 2025 - NFL
Jan 12, 2025 - NFL
Jan 5, 2025 - NFL
Dec 29, 2024 - NFL
Dec 8, 2024 - NFL
5/6 (83%)
0/6 (0%)
1/6 (17%)
Oct 5, 2025 - NFL
Sep 15, 2025 - NFL
Sep 7, 2025 - NFL
Dec 22, 2024 - NFL
Dec 15, 2024 - NFL
Dec 1, 2024 - NFL
San Francisco 49ers against Tampa Bay Buccaneers : Head to Head (H2H)
100 %
0 %
0 %
Nov 10, 2024 - NFL
Nov 19, 2023 - NFL
Dec 11, 2022 - NFL
San Francisco 49ers - Tampa Bay Buccaneers Key Points
- All 5 of the Bucs' games this season have been decided by 1-6 points
- The Bucs have won 6 of their last 7 regular season games
- All 5 of the Niners' games this season have been decided by 1-6 points
- San Fran have a point differential of -1 over the last 3 weeks
Limited Offer. Currently at Caesars Sportsbook
Our San Francisco 49ers vs Tampa Bay Buccaneers Prediction
This looks set to be a thrilling and extremely close contest between two of the strongest teams in the NFC.
The Niners have done remarkably well to reach 4-1, despite battling an ever-growing injury crisis that has deprived them of several regular starters in the opening weeks of the season.
However, we are going to side with the Bucs in this one. QB Baker Mayfield is enjoying a stellar season, rookie WR Emeka Egbuka already looks like an elite NFL receiver and Rachaad White is doing an excellent job manning the Tampa running game in the absence of Bucky Irving.
Our prediction for Tampa Bay Buccaneers vs San Francisco 49ers is: Tampa to win by 1-6 points.
Take advantage of this offer for your San Francisco 49ers vs Tampa Bay Buccaneers wager!
For this NFL season, Caesars is offering a unique promo for your SGPs. Participating is as simple as opting in and placing a $5 minimum, 3-leg parlay with odds of +100 or longer on any NFL match this season, including for this San Francisco 49ers vs Tampa Bay Buccaneers matchup!
If you meet the requirements and either team scores 50+, you'll win a share of the prize pool! So do your research and get your same game parlay ready!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
Limited Offer. Currently at Caesars Sportsbook
