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by Matt Lowrimore in NFL Picks
Week 5 of the NFL will kick off on Thursday night with an NFC West rivalry between the Los Angeles Rams and the San Francisco 49ers. Let’s take a look at the match statistics and predictions for this game between the Rams and the 49ers.
San Francisco enters this game with a record of 3-1, having most recently lost to the Jacksonville Jaguars in Week 4 by a score of 26-21. The 49ers’ offense had a total of 389 yards, while its defense allowed 325 yards. Quarterback Brock Purdy threw for 309 yards, two touchdowns, and two interceptions, while running back Christian McCaffrey led the team in rushing with 49 yards and receiving with 92 yards, with one touchdown.
As for Los Angeles, they also enter this game with a record of 3-1, having most recently beaten the Indianapolis Colts by a score of 27-20. The Rams’ offense had a total of 462 yards, while its defense allowed 333 yards. Quarterback Matthew Stafford threw for 375 yards and three touchdowns, while running back Kyren Williams led the team in rushing with 77 yards.
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San Francisco 49ers vs Los Angeles Rams Form
Table
| Teams | % | P | W | D | L |
|---|---|---|---|---|---|
|
3
|
0.8 | 5 | 4 | 0 | 1 |
|
12
|
0.6 | 5 | 3 | 0 | 2 |
San Francisco 49ers and Los Angeles Rams Latest Matches
3/6 (50%)
0/6 (0%)
3/6 (50%)
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2/6 (33%)
0/6 (0%)
4/6 (67%)
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2/6 (33%)
0/6 (0%)
4/6 (67%)
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4/6 (67%)
0/6 (0%)
2/6 (33%)
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5/6 (83%)
0/6 (0%)
1/6 (17%)
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Jan 5, 2025 - NFL
Dec 28, 2024 - NFL
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4/6 (67%)
0/6 (0%)
2/6 (33%)
Sep 21, 2025 - NFL
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San Francisco 49ers against Los Angeles Rams : Head to Head (H2H)
50 %
0 %
50 %
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San Francisco 49ers - Los Angeles Rams Key Points
- The 49ers are 2-2 ATS this season
- The Rams are 3-1 ATS this season
- The 49ers are averaging 20.0 points per game this season
- The Rams are averaging 25.0 points per game this season
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Our San Francisco 49ers vs Los Angeles Rams Prediction
The Rams are a decent-sized favorite in this game, but still look to be the best betting option. Los Angeles’ offense has been far superior to that of San Francisco, as the Rams are averaging 25 points per game, compared to the 49ers, who are averaging 20 points per game.
More specifically, Rams quarterback Matthew Stafford has already thrown for 1,114 yards this season, eight touchdowns, and just two interceptions. As for the 49ers, their quarterback, Brock Purdy, has been mediocre at best and is still dealing with an injury that has him questionable for this game.
Even if Purdy is cleared for Thursday’s game, the Rams' offensive firepower cannot be underestimated. For that reason, our Los Angeles Rams vs San Francisco 49ers prediction is: Los Angeles Rams ML.Jackpot Pools
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
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