San Francisco 49ers vs Houston Texans Prediction & Picks - NFL

USA - NFL

San Francisco 49ers
10/26/25 13:00
Houston Texans

Prediction:

 

San Francisco 49ers ML

-108
$300+ offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Matt Lowrimore in NFL Picks

Week 8 of the NFL will continue on Sunday with a matchup between the Houston Texans and the San Francisco 49ers. Let’s take a look at the match statistics and predictions for this game between the Texans and the 49ers.

San Francisco enters this game with a record of 5-2, having most recently beaten the Atlanta Falcons in Week 7 by a score of 20-10. The 49ers’ offense had a total of 324 yards, while its defense allowed 292 yards. Quarterback Mac Jones threw for 152 yards and one interception, while running back Christian McCaffrey led the team in rushing with 129 yards and two touchdowns.

As for Houston, they enter this game with a record of 2-4, having most recently lost to the Seattle Seahawks in Week 7 by a score of 27-19. The Texans’ offense had a total of 254 yards, while its defense allowed 316 yards. Quarterback C.J. Stroud threw for 229 yards, one touchdown, and one interception, while also leading the team in rushing with 25 yards.

San Francisco 49ers vs Houston Texans Form

Table

Teams % P W D L
4
San Francisco 49ers
San Francisco 49ers
0.714 7 5 0 2
23
Houston Texans
Houston Texans
0.333 6 2 0 4

San Francisco 49ers and Houston Texans Latest Matches

San Francisco 49ers
San Francisco 49ers Latest matches
W W L W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 19, 2025 - NFL

Atlanta Falcons
10 :  20
San Francisco 49ers

Oct 12, 2025 - NFL

San Francisco 49ers
19 :  30
Tampa Bay Buccaneers

Oct 2, 2025 - NFL

San Francisco 49ers
26 :  23
Los Angeles Rams

Sep 28, 2025 - NFL

Jacksonville Jaguars
26 :  21
San Francisco 49ers

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers

Sep 14, 2025 - NFL

San Francisco 49ers
26 :  21
New Orleans Saints
W L L W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 19, 2025 - NFL

Atlanta Falcons
10 :  20
San Francisco 49ers

Sep 28, 2025 - NFL

Jacksonville Jaguars
26 :  21
San Francisco 49ers

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers

Dec 30, 2024 - NFL

Detroit Lions
40 :  34
San Francisco 49ers

Dec 12, 2024 - NFL

Los Angeles Rams
12 :  6
San Francisco 49ers

Dec 8, 2024 - NFL

Chicago Bears
13 :  38
San Francisco 49ers
L L W W W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 12, 2025 - NFL

San Francisco 49ers
19 :  30
Tampa Bay Buccaneers

Oct 2, 2025 - NFL

San Francisco 49ers
26 :  23
Los Angeles Rams

Sep 14, 2025 - NFL

San Francisco 49ers
26 :  21
New Orleans Saints

Sep 7, 2025 - NFL

San Francisco 49ers
17 :  13
Seattle Seahawks

Jan 5, 2025 - NFL

San Francisco 49ers
24 :  47
Arizona Cardinals

Dec 22, 2024 - NFL

San Francisco 49ers
17 :  29
Miami Dolphins
Houston Texans
Houston Texans Latest matches
L L L W W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Oct 20, 2025 - NFL

Houston Texans
19 :  27
Seattle Seahawks

Oct 5, 2025 - NFL

Houston Texans
44 :  10
Baltimore Ravens

Sep 28, 2025 - NFL

Tennessee Titans
0 :  26
Houston Texans

Sep 21, 2025 - NFL

Houston Texans
10 :  17
Jacksonville Jaguars

Sep 15, 2025 - NFL

Tampa Bay Buccaneers
20 :  19
Houston Texans

Sep 7, 2025 - NFL

Houston Texans
9 :  14
Los Angeles Rams
L W L W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 28, 2025 - NFL

Tennessee Titans
0 :  26
Houston Texans

Sep 15, 2025 - NFL

Tampa Bay Buccaneers
20 :  19
Houston Texans

Jan 11, 2025 - NFL

Los Angeles Chargers
12 :  32
Houston Texans

Dec 25, 2024 - NFL

Baltimore Ravens
31 :  2
Houston Texans

Dec 15, 2024 - NFL

Miami Dolphins
12 :  20
Houston Texans

Nov 24, 2024 - NFL

Tennessee Titans
32 :  27
Houston Texans
W L L L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Oct 20, 2025 - NFL

Houston Texans
19 :  27
Seattle Seahawks

Oct 5, 2025 - NFL

Houston Texans
44 :  10
Baltimore Ravens

Sep 21, 2025 - NFL

Houston Texans
10 :  17
Jacksonville Jaguars

Sep 7, 2025 - NFL

Houston Texans
9 :  14
Los Angeles Rams

Jan 18, 2025 - NFL

Houston Texans
14 :  23
Kansas City Chiefs

Jan 5, 2025 - NFL

Houston Texans
23 :  14
Tennessee Titans

San Francisco 49ers - Houston Texans Key Points

  1. San Francisco is 4-3 ATS this season
  2. San Francisco is averaging 20.7 points per game this season
  3. Houston is 2-4 ATS this season
  4. Houston is averaging 21.2 points per game this season

Our San Francisco 49ers vs Houston Texans Prediction

Houston is the small favorite in this game, which is a bit surprising given that they have a poor record this season. The Texans only have wins against an even worse Tennessee Titans team and a Baltimore Ravens team that was missing Lamar Jackson.

San Francisco, on the other hand, is playing like one of the top teams in the NFC. This is especially true given that Christian McCaffrey just had a 200+ yard game from scrimmage.

The Texans have simply been too inconsistent to trust, especially as a favorite. For that reason, our Houston Texans vs San Francisco 49ers prediction is: San Francisco 49ers ML.

Prediction:

 

San Francisco 49ers ML

-108
$300+ offered for betting!

Claim $300+ for your San Francisco 49ers vs Houston Texans wager!

DK Welcome Bonus

Would you like to bet on San Francisco 49ers vs Houston Texans? For this NFL match, DK treats you to an exclusive offer: a bonus of $300+, no promo code needed! Take advantage while you still can!

Not registered yet? You can create your account now with our link below. A bonus of $300+ awaits you on the San Francisco 49ers vs Houston Texans match!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

San Francisco 49ers vs Houston Texans Picks