Carolina Panthers vs Buffalo Bills Prediction & Picks - NFL
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by Matt Lowrimore | in NFL Picks
Another one of the games on the Week 8 NFL slate will see the Carolina Panthers take on the Buffalo Bills. Let’s take a look at the match statistics and predictions for this game between the Panthers and the Bills.
Buffalo enters this game with a record of 4-2, having most recently lost to the Atlanta Falcons in Week 6 by a score of 24-14. The Bills’ offense had a total of 291 yards, while its defense allowed 443 yards. Quarterback Josh Allen threw for 180 yards, two touchdowns, and two interceptions, while running back James Cook led the team in rushing with 87 yards.
As for Carolina, they enter this game with a record of 4-3, having most recently beaten the New York Jets in Week 7 by a score of 13-6. The Panthers’ offense had a total of 302 yards, while its defense allowed 220 yards. Quarterback Bryce Young threw for 138 yards and one touchdown, while running back Rico Dowdle led the team in rushing with 79 yards.
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Carolina Panthers vs Buffalo Bills Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
8
|
0.706 | 17 | 12 | 5 |
|
18
|
0.471 | 17 | 8 | 9 |
Carolina Panthers and Buffalo Bills Latest Matches
4/6 (67%)
2/6 (33%)
Oct 19, 2025 - NFL
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4/6 (67%)
2/6 (33%)
Oct 12, 2025 - NFL
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2/6 (33%)
4/6 (67%)
Oct 19, 2025 - NFL
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Dec 29, 2024 - NFL
4/6 (67%)
2/6 (33%)
Oct 13, 2025 - NFL
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Sep 28, 2025 - NFL
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Sep 14, 2025 - NFL
Sep 7, 2025 - NFL
5/6 (83%)
1/6 (17%)
Oct 5, 2025 - NFL
Sep 28, 2025 - NFL
Sep 18, 2025 - NFL
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Jan 19, 2025 - NFL
Jan 12, 2025 - NFL
2/6 (33%)
4/6 (67%)
Oct 13, 2025 - NFL
Sep 14, 2025 - NFL
Jan 26, 2025 - NFL
Jan 5, 2025 - NFL
Dec 15, 2024 - NFL
Dec 8, 2024 - NFL
Carolina Panthers - Buffalo Bills Key Points
- Buffalo is 2-4 ATS this season
- Buffalo is averaging 27.8 points per game this season
- Carolina is 5-2 ATS this season
- Carolina is averaging 20.7 points per game this season
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Our Carolina Panthers vs Buffalo Bills Prediction
Buffalo is a touchdown favorite in this game, but given their recent performances, looking at Carolina to keep this game close could be the best betting option. The Panthers have had surprising success this season, especially against the spread. Carolina has covered the spread in five of their seven games, while Buffalo has covered in just two of their six games.
The main concern for the Panthers is the status of their quarterback, Bryce Young. That being said, Andy Dalton is an NFL veteran and should have enough success against a Bills’ defense that has not performed well recently.
The Bills did just have their bye week, but because of their inability to put teams away recently, our Carolina Panthers vs Buffalo Bills prediction is: Carolina Panthers +7.All tips are fully researched and given in good faith, but profits cannot be guaranteed.
