Indianapolis Colts vs Tennessee Titans Prediction & Picks - NFL

Prediction published on 10/26/25, 12:39 PM  by Travis Pulver | Modified on 1/13/26 at 9:14 AM in NFL Picks

The Colts (6-1) will try to keep the good times rolling this week when they host the Tennessee Titans (1-6) at Lucas Oil Stadium in Indianapolis, IN. Kickoff for this AFC South battle is scheduled for 4:25 p.m. EST and will be broadcast on CBS.

This will be the second game between these division rivals. Indianapolis won the first in Nashville back in Week 3, 41-20. Daniel Jones had an efficient day, going 18-25 for 228 yards and one touchdown (he was not sacked). He tacked on another 27 yards on the ground, where Jonathan Taylor led the way with 107 yards and three touchdowns. Cam Ward struggled to get the Titans offense on track, completing 23 of 38 pass attempts for 219 yards and a touchdown with one interception (he was sacked four times). It probably would have helped if they could have established a run game (23 carries for 86 yards and a score).

Indianapolis went on to lose its first game the following week vs. the Rams, but has since bounced back behind the play of Daniel Jones and the Colts' offense and won three in a row. Tennessee finally got a win in Week 5 vs. the Cardinals in Arizona.