Oklahoma Sooners vs Ole Miss Rebels Prediction & Picks - NCAA

USA - NCAA

Oklahoma Sooners
10/25/25 12:00
Ole Miss Rebels

Prediction:

 

Ole Miss Rebels +4.5

-105
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 by Matt Lowrimore | in NCAA Picks

One of the top games on the Week 9 college football slate will see the 8th-ranked Ole Miss Rebels take on the 13th-ranked Oklahoma Sooners in the SEC. Let’s take a look at the match statistics and predictions for this game between the Rebels and the Sooners.

Ole Miss enters this game with a record of 6-1 and 3-1 in the SEC. The Rebels most recently lost to the Georgia Bulldogs in Week 8 by a score of 43-35. Ole Miss’ offense had a total of 351 yards, while its defense allowed 510 yards. Quarterback Trinidad Chambliss threw for 263 yards and one touchdown, while also leading the team in rushing with 42 yards and two touchdowns.

As for Oklahoma, they enter this game with a record of 6-1 and 2-1 in the SEC. The Sooners most recently beat the South Carolina Gamecocks in Week 8 by a score of 26-7. Oklahoma’s offense had a total of 319 yards, while its defense allowed 224 yards. Quarterback John Mateer threw for 150 yards and one touchdown, while running back Tory Blaylock led the team in rushing with 101 yards and one touchdown.

Oklahoma Sooners vs Ole Miss Rebels Form

Table

Oklahoma Sooners and Ole Miss Rebels Latest Matches

Oklahoma Sooners
Oklahoma Sooners Latest matches
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 18, 2025 - NCAA

South Carolina Gamecocks
7 :  26
Oklahoma Sooners

Oct 11, 2025 - NCAA

Texas Longhorns
23 :  6
Oklahoma Sooners

Oct 4, 2025 - NCAA

Oklahoma Sooners
44 :  0
Kent State Golden Flashes

Sep 20, 2025 - NCAA

Oklahoma Sooners
24 :  17
Auburn Tigers

Sep 13, 2025 - NCAA

Temple Owls
3 :  42
Oklahoma Sooners

Sep 6, 2025 - NCAA

Oklahoma Sooners
24 :  13
Michigan Wolverines
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 4, 2025 - NCAA

Oklahoma Sooners
44 :  0
Kent State Golden Flashes

Sep 20, 2025 - NCAA

Oklahoma Sooners
24 :  17
Auburn Tigers

Sep 6, 2025 - NCAA

Oklahoma Sooners
24 :  13
Michigan Wolverines

Aug 30, 2025 - NCAA

Oklahoma Sooners
35 :  3
Illinois State Redbirds

Oct 19, 2024 - NCAA

Oklahoma Sooners
9 :  35
South Carolina Gamecocks

Sep 21, 2024 - NCAA

Oklahoma Sooners
15 :  25
Tennessee Volunteers
W L W
Victories

2/3 (67%)

Defeats

1/3 (33%)

Oct 18, 2025 - NCAA

South Carolina Gamecocks
7 :  26
Oklahoma Sooners

Oct 11, 2025 - NCAA

Texas Longhorns
23 :  6
Oklahoma Sooners

Sep 13, 2025 - NCAA

Temple Owls
3 :  42
Oklahoma Sooners
Ole Miss Rebels
Ole Miss Rebels Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 18, 2025 - NCAA

Georgia Bulldogs
43 :  35
Ole Miss Rebels

Oct 11, 2025 - NCAA

Ole Miss Rebels
24 :  21
Washington State Cougars

Sep 27, 2025 - NCAA

Ole Miss Rebels
24 :  19
LSU Tigers

Sep 20, 2025 - NCAA

Ole Miss Rebels
45 :  10
Tulane Green Wave

Sep 13, 2025 - NCAA

Ole Miss Rebels
41 :  35
Arkansas Razorbacks

Sep 6, 2025 - NCAA

Kentucky Wildcats
23 :  30
Ole Miss Rebels
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 11, 2025 - NCAA

Ole Miss Rebels
24 :  21
Washington State Cougars

Sep 27, 2025 - NCAA

Ole Miss Rebels
24 :  19
LSU Tigers

Sep 20, 2025 - NCAA

Ole Miss Rebels
45 :  10
Tulane Green Wave

Sep 13, 2025 - NCAA

Ole Miss Rebels
41 :  35
Arkansas Razorbacks

Aug 30, 2025 - NCAA

Ole Miss Rebels
63 :  7
Georgia State Panthers

Sep 28, 2024 - NCAA

Ole Miss Rebels
17 :  20
Kentucky Wildcats
W L
Victories

1/2 (50%)

Defeats

1/2 (50%)

Oct 18, 2025 - NCAA

Georgia Bulldogs
43 :  35
Ole Miss Rebels

Sep 6, 2025 - NCAA

Kentucky Wildcats
23 :  30
Ole Miss Rebels

Oklahoma Sooners - Ole Miss Rebels Key Points

  1. Ole Miss is 2-2 ATS vs the SEC
  2. Ole Miss is averaging 32.5 points per game vs the SEC
  3. Oklahoma is 2-1 ATS vs the SEC
  4. Oklahoma is averaging 18.7 points per game vs the SEC

Our Oklahoma Sooners vs Ole Miss Rebels Prediction

Ole Miss fell from the unbeaten last week when they lost to Georgia, and now face another road test against Oklahoma. The Rebels’ offense torched the Bulldogs for most of the game, but at the same time, their defense could not get off the field. 

Oklahoma, on the other hand, cruised in their game against South Carolina, but their quarterback, John Mateer, still did not have a great performance. 

At this point in the season, picking up a second loss could eliminate either side from the SEC Championship and possibly the College Football Playoffs. While this game is being played in Oklahoma, Ole Miss is sure to make the necessary adjustments from what they saw last week. For that reason, our Ole Miss Rebels vs Oklahoma Sooners prediction is: Ole Miss Rebels +4.5.

Prediction:

 

Ole Miss Rebels +4.5

-105
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Oklahoma Sooners vs Ole Miss Rebels Picks