Philadelphia Eagles vs Buffalo Bills Prediction & Picks - NFL

Prediction published on 12/28/25, 1:25 PM  by Bill Christy in NFL Picks

The Buffalo Bills (11-4) still have a chance to steal the AFC East from the New England Patriots. However, they have a very tough matchup this week in the Philadelphia Eagles (10-5). This was and possibly still could be a potential Super Bowl matchup between one of the best teams in each conference.

Buffalo is coming off a scary 23-20 win over the Cleveland Browns. In the win, Josh Allen was banged up, and his status is still uncertain for this game. That said, the win did make it 4 in-a-row for the Bills. It has been the offense that has carried Buffalo throughout the year, while the defense has been middle-of-the-road. Allen, even at half strength, is better than anyone else the Bills could put out under center. With the spread being so short, likely, he is still going to play.

Philadelphia has seemingly calmed its rowdy fan base with back-to-back wins over the Raiders and Commanders. However, if they are to lose here in Buffalo, expect those same fans to be calling for a new coach, offensive coordinator, and quarterback. The offense has looked strong the last two weeks. Saquon has rushed for over 200 yards and 2 touchdowns in the wins, while Hurts has tossed for 5 touchdowns through the air.

It will be Allen vs Hurts in a marquee QB matchup when Philly heads into Buffalo. However, it could be the defenses that make the most noise in this one.