Indiana Hoosiers vs Ohio State Buckeyes Prediction & Picks - NCAA

USA - NCAA

Indiana Hoosiers
10/17/26 12:00
Ohio State Buckeyes

Prediction:

 

Ohio State Buckeyes -2.5 Alternate Spread

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 by Matt Lowrimore | in NCAA Picks

One of the biggest matchups on the Week 7 College Football Saturday slate will feature a Big Ten matchup between the #4-ranked Ohio State Buckeyes and the #5-ranked Indiana Hoosiers. Let’s take a look at the match statistics and predictions for this game between the Buckeyes and the Hoosiers.

Ohio State enters this game with a record of 5-1 and 3-0 in the Big Ten. The Buckeyes are coming off a 45-16 win over Maryland in Week 6, where they produced 449 yards of offense and allowed just 146 yards. It should be noted that Ohio State’s only loss this season was on the road this season to Texas. However, since that loss, the Buckeyes have crushed every team they have faced and should have similar success against Indiana.

As for Indiana, they enter this game with a record of 6-0 and 3-0 in the Big Ten. The Hoosiers are coming off a 20-17 win against Nebraska in Week 6. Despite the win, the Hoosiers struggled for the majority of this game, only totaling 328 yards of offense while allowing 391 yards. Indiana has the luxury of playing at home in this game, but needs to be much better if they are going to win.

Indiana Hoosiers vs Ohio State Buckeyes Form

Table

Indiana Hoosiers and Ohio State Buckeyes Latest Matches

Indiana Hoosiers
Indiana Hoosiers Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Oct 10, 2026 - NCAA

Nebraska Cornhuskers
17 :  20
Indiana Hoosiers

Oct 3, 2026 - NCAA

Rutgers Scarlet Knights
15 :  47
Indiana Hoosiers

Sep 25, 2026 - NCAA

Indiana Hoosiers
29 :  23
Northwestern Wildcats

Sep 19, 2026 - NCAA

Indiana Hoosiers
38 :  0
Western Kentucky Hilltoppers

Sep 12, 2026 - NCAA

Indiana Hoosiers
55 :  0
Howard Bison

Sep 5, 2026 - NCAA

Indiana Hoosiers
52 :  16
North Texas Mean Green
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 25, 2026 - NCAA

Indiana Hoosiers
29 :  23
Northwestern Wildcats

Sep 19, 2026 - NCAA

Indiana Hoosiers
38 :  0
Western Kentucky Hilltoppers

Sep 12, 2026 - NCAA

Indiana Hoosiers
55 :  0
Howard Bison

Sep 5, 2026 - NCAA

Indiana Hoosiers
52 :  16
North Texas Mean Green

Jan 19, 2026 - NCAA

Indiana Hoosiers
27 :  21
Miami Hurricanes

Jan 9, 2026 - NCAA

Indiana Hoosiers
56 :  22
Oregon Ducks
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Oct 10, 2026 - NCAA

Nebraska Cornhuskers
17 :  20
Indiana Hoosiers

Oct 3, 2026 - NCAA

Rutgers Scarlet Knights
15 :  47
Indiana Hoosiers

Dec 6, 2025 - NCAA

Ohio State Buckeyes
10 :  13
Indiana Hoosiers

Nov 28, 2025 - NCAA

Purdue Boilermakers
3 :  56
Indiana Hoosiers

Nov 8, 2025 - NCAA

Penn State Nittany Lions
24 :  27
Indiana Hoosiers

Nov 1, 2025 - NCAA

Maryland Terrapins
10 :  55
Indiana Hoosiers
Ohio State Buckeyes
Ohio State Buckeyes Latest matches
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 10, 2026 - NCAA

Ohio State Buckeyes
45 :  16
Maryland Terrapins

Oct 3, 2026 - NCAA

Iowa Hawkeyes
14 :  31
Ohio State Buckeyes

Sep 26, 2026 - NCAA

Ohio State Buckeyes
42 :  19
Illinois Fighting Illini

Sep 19, 2026 - NCAA

Ohio State Buckeyes
59 :  3
Kent State Golden Flashes

Sep 12, 2026 - NCAA

Texas Longhorns
24 :  23
Ohio State Buckeyes

Sep 5, 2026 - NCAA

Ohio State Buckeyes
56 :  3
Ball State Cardinals
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 10, 2026 - NCAA

Ohio State Buckeyes
45 :  16
Maryland Terrapins

Sep 26, 2026 - NCAA

Ohio State Buckeyes
42 :  19
Illinois Fighting Illini

Sep 19, 2026 - NCAA

Ohio State Buckeyes
59 :  3
Kent State Golden Flashes

Sep 5, 2026 - NCAA

Ohio State Buckeyes
56 :  3
Ball State Cardinals

Dec 31, 2025 - NCAA

Ohio State Buckeyes
14 :  24
Miami Hurricanes

Dec 6, 2025 - NCAA

Ohio State Buckeyes
10 :  13
Indiana Hoosiers
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 3, 2026 - NCAA

Iowa Hawkeyes
14 :  31
Ohio State Buckeyes

Sep 12, 2026 - NCAA

Texas Longhorns
24 :  23
Ohio State Buckeyes

Nov 29, 2025 - NCAA

Michigan Wolverines
9 :  27
Ohio State Buckeyes

Nov 8, 2025 - NCAA

Purdue Boilermakers
10 :  34
Ohio State Buckeyes

Oct 18, 2025 - NCAA

Wisconsin Badgers
0 :  34
Ohio State Buckeyes

Oct 11, 2025 - NCAA

Illinois Fighting Illini
16 :  34
Ohio State Buckeyes

Indiana Hoosiers against Ohio State Buckeyes : Head to Head (H2H)

Indiana Hoosiers

100 %

Ohio State Buckeyes

0 %

Dec 6, 2025 - NCAA

Ohio State Buckeyes
10 :  13
Indiana Hoosiers
Indiana Hoosiers vs Ohio State Buckeyes Picks

Indiana Hoosiers - Ohio State Buckeyes Key Points

  1. Ohio State is 4-2 ATS this season
  2. Ohio State is averaging 42.7 points per game this season
  3. Indiana is 3-3 ATS this season
  4. Indiana is averaging 40.2 points per game this season

Our Indiana Hoosiers vs Ohio State Buckeyes Prediction

Ohio State is the road favorite in this game; however, they still look to be the best betting option. For one, the Buckeyes are 4-2 ATS this season, while the Hoosiers are 3-3 ATS. Further, Ohio State has won their Big Ten games by an average margin of 23.0 points per game.

The Buckeyes also have an offense averaging 42.7 points per game overall and 39.3 points per game in three Big Ten games.

This game is sure to be close with both teams ranked inside the top-5; however, the Buckeyes have overall been the more consistent team. For that reason, our Ohio State Buckeyes vs. Indiana Hoosiers prediction is: Ohio State Buckeyes -2.5 Alternate Spread.

Prediction:

 

Ohio State Buckeyes -2.5 Alternate Spread

−154
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.