LSU Tigers vs Mississippi State Bulldogs Prediction & Picks - NCAA

USA - NCAA

LSU Tigers
10/17/26 12:00
Mississippi State Bulldogs

Prediction:

 

Mississippi State Bulldogs +14.5

−112
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 by Matt Lowrimore | in NCAA Picks

Another huge game on the Week 7 College Football Saturday slate will feature a matchup in the SEC between the #16-ranked Mississippi State Bulldogs and the #22-ranked LSU Tigers. Let’s take a look at the match statistics and predictions for this game between the Bulldogs and the Tigers.

Mississippi State enters this game with a record of 4-1 and 2-1 in the SEC. The Bulldogs are coming off their bye week and most recently lost to Alabama in Week 5 by a score of 56-23. Mississippi State was clearly overmatched in this game, as they had 302 yards of offense while allowing 483 yards. Despite this setback, the Bulldogs have still been a pleasant surprise this season and have a good chance of bouncing back with a competitive game against an overrated LSU side. 

As for LSU, they enter this game with a record of 4-2 and 1-2 in the SEC. The Tigers are coming off a 35-34 overtime upset loss to Kentucky in Week 6. LSU managed to total 410 yards of offense, but their defense once again struggled, allowing 401 yards. The Tigers' first season with Lane Kiffin as their head coach has not gone as expected, and with that, there is plenty of reason to believe they will continue to struggle.

LSU Tigers vs Mississippi State Bulldogs Form

Table

LSU Tigers and Mississippi State Bulldogs Latest Matches

LSU Tigers
LSU Tigers Latest matches
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 10, 2026 - NCAA

Kentucky Wildcats
35 :  34
LSU Tigers

Oct 3, 2026 - NCAA

LSU Tigers
63 :  14
McNeese State Cowboys

Sep 26, 2026 - NCAA

LSU Tigers
35 :  6
Texas A&M Aggies

Sep 19, 2026 - NCAA

Ole Miss Rebels
32 :  24
LSU Tigers

Sep 12, 2026 - NCAA

LSU Tigers
45 :  14
Louisiana Tech Bulldogs

Sep 5, 2026 - NCAA

LSU Tigers
51 :  10
Clemson Tigers
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Oct 3, 2026 - NCAA

LSU Tigers
63 :  14
McNeese State Cowboys

Sep 26, 2026 - NCAA

LSU Tigers
35 :  6
Texas A&M Aggies

Sep 12, 2026 - NCAA

LSU Tigers
45 :  14
Louisiana Tech Bulldogs

Sep 5, 2026 - NCAA

LSU Tigers
51 :  10
Clemson Tigers

Nov 22, 2025 - NCAA

LSU Tigers
13 :  10
Western Kentucky Hilltoppers

Nov 15, 2025 - NCAA

LSU Tigers
23 :  22
Arkansas Razorbacks
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Oct 10, 2026 - NCAA

Kentucky Wildcats
35 :  34
LSU Tigers

Sep 19, 2026 - NCAA

Ole Miss Rebels
32 :  24
LSU Tigers

Dec 27, 2025 - NCAA Division I, FBS, Playoffs

Houston Cougars
38 :  35
LSU Tigers

Nov 29, 2025 - NCAA

Oklahoma Sooners
17 :  13
LSU Tigers

Nov 8, 2025 - NCAA

Alabama Crimson Tide
20 :  9
LSU Tigers

Oct 18, 2025 - NCAA

Vanderbilt Commodores
31 :  24
LSU Tigers
Mississippi State Bulldogs
Mississippi State Bulldogs Latest matches
L W W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 3, 2026 - NCAA

Mississippi State Bulldogs
23 :  56
Alabama Crimson Tide

Sep 26, 2026 - NCAA

Mississippi State Bulldogs
31 :  24
Missouri Tigers

Sep 19, 2026 - NCAA

South Carolina Gamecocks
34 :  41
Mississippi State Bulldogs

Sep 12, 2026 - NCAA

Minnesota Golden Gophers
13 :  38
Mississippi State Bulldogs

Sep 5, 2026 - NCAA

Mississippi State Bulldogs
62 :  13
Louisiana-Monroe Warhawks

Jan 2, 2026 - NCAA Division I, FBS, Playoffs

Mississippi State Bulldogs
29 :  43
Wake Forest Demon Deacons
L L L W W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 3, 2026 - NCAA

Mississippi State Bulldogs
23 :  56
Alabama Crimson Tide

Sep 26, 2026 - NCAA

Mississippi State Bulldogs
31 :  24
Missouri Tigers

Sep 5, 2026 - NCAA

Mississippi State Bulldogs
62 :  13
Louisiana-Monroe Warhawks

Jan 2, 2026 - NCAA Division I, FBS, Playoffs

Mississippi State Bulldogs
29 :  43
Wake Forest Demon Deacons

Nov 28, 2025 - NCAA

Mississippi State Bulldogs
19 :  38
Ole Miss Rebels

Nov 8, 2025 - NCAA

Mississippi State Bulldogs
21 :  41
Georgia Bulldogs
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 19, 2026 - NCAA

South Carolina Gamecocks
34 :  41
Mississippi State Bulldogs

Sep 12, 2026 - NCAA

Minnesota Golden Gophers
13 :  38
Mississippi State Bulldogs

Nov 15, 2025 - NCAA

Missouri Tigers
49 :  27
Mississippi State Bulldogs

Nov 1, 2025 - NCAA

Arkansas Razorbacks
35 :  38
Mississippi State Bulldogs

Oct 18, 2025 - NCAA

Florida Gators
23 :  21
Mississippi State Bulldogs

Oct 4, 2025 - NCAA

Texas A&M Aggies
31 :  9
Mississippi State Bulldogs
LSU Tigers vs Mississippi State Bulldogs Picks

LSU Tigers - Mississippi State Bulldogs Key Points

  1. Mississippi State is 4-1 ATS this season
  2. Mississippi State is averaging 39.0 points per game this season
  3. LSU is 2-4 ATS this season
  4. LSU is averaging 42.0 points per game this season

Our LSU Tigers vs Mississippi State Bulldogs Prediction

LSU is more than a two-touchdown favorite in this game; however, Mississippi State looks to be the best betting option. Through six weeks of this season, the Tigers continue to prove they are not a team that can be trusted. Sure, LSU can beat the mid-major schools, but when playing SEC teams, they have struggled more often than not.

It is fair to point out that both of LSU’s losses have been on the road, and Mississippi State is coming off a blowout loss to Alabama. That said, the Bulldogs still have one of the better quarterbacks in the country, and they have had extra time to prepare for this game. 

At the very least, this game should be back and forth; therefore, our Mississippi State Bulldogs vs. LSU Tigers prediction is: Mississippi State Bulldogs +14.5.

Prediction:

 

Mississippi State Bulldogs +14.5

−112
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.