Miami Dolphins vs Indianapolis Colts Prediction & Picks - NFL

USA - NFL

Miami Dolphins
9/7/25 13:00
Indianapolis Colts

Prediction:

 

The Colts will win

-108
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 by Lou Aguila in NFL Picks

The Indianapolis Colts will debut their new quarterback, Daniel Jones, in Sunday’s season opener against the visiting Miami Dolphins at Lucas Oil Stadium.

Bookmakers anticipate a close battle, with the Colts listed as slight favorites on the run line at -1.5 points (-102). It means the home team only needs to beat the Dolphins by at least two points to beat the spread.

Current Form:

After dropping their first two preseason games against the Baltimore Ravens (16-24) and the Golden Bay Packers (19-23), Indianapolis closed out its offseason buildup with a resounding 41-14 win over the Cincinnati Bengals. Backup quarterback Riley Leonard got a starting role in this game, covering 189 yards on 15 of 20 passing with one touchdown. Rookie running back Ulysses Bentley IV ran for 189 yards and scored one TD. Daniels Jones, who beat Anthony Richardson Sr. for the starting quarterback job, delivered solid numbers in the first two preseason games. Jones completed 10 of her 21 passes for 144 yards in a loss to the Ravens in Week 1 preseason and went 7-for-11 for 109 yards in another setback to the Packers.

The Dolphins wrapped up their three-game preseason schedule undefeated. Miami duked it out to a 24-24 tie with the Chicago Bears in Week 1 before outgunning the Detroit Lions 24-17 in Week 2. The Dolphins punctuated their offseason buildup with a 14-6 victory over the Jacksonville Jaguars in Week 3. Dolphins quarterback Tua Tagovailoa is set for his fifth consecutive season-opening start.

Miami Dolphins vs Indianapolis Colts Form

Table

Teams % P W D L
3
Indianapolis Colts
Indianapolis Colts
1 1 1 0 0
31
Miami Dolphins
Miami Dolphins
0 1 0 0 1

Miami Dolphins and Indianapolis Colts Latest Matches

Miami Dolphins
Miami Dolphins Latest matches
L W L W W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Jan 5, 2025 - NFL

Miami Dolphins
20 :  32
New York Jets

Dec 29, 2024 - NFL

Miami Dolphins
20 :  3
Cleveland Browns

Dec 22, 2024 - NFL

San Francisco 49ers
17 :  29
Miami Dolphins

Dec 15, 2024 - NFL

Miami Dolphins
12 :  20
Houston Texans

Dec 8, 2024 - NFL

New York Jets
26 :  32
Miami Dolphins

Nov 28, 2024 - NFL

Miami Dolphins
17 :  30
Green Bay Packers
L L W W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 22, 2024 - NFL

San Francisco 49ers
17 :  29
Miami Dolphins

Dec 8, 2024 - NFL

New York Jets
26 :  32
Miami Dolphins

Nov 24, 2024 - NFL

New England Patriots
15 :  34
Miami Dolphins

Nov 17, 2024 - NFL

Las Vegas Raiders
19 :  34
Miami Dolphins

Oct 27, 2024 - NFL

Arizona Cardinals
28 :  27
Miami Dolphins

Sep 30, 2024 - NFL

Tennessee Titans
31 :  12
Miami Dolphins
L W L L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Jan 5, 2025 - NFL

Miami Dolphins
20 :  32
New York Jets

Dec 29, 2024 - NFL

Miami Dolphins
20 :  3
Cleveland Browns

Dec 15, 2024 - NFL

Miami Dolphins
12 :  20
Houston Texans

Nov 28, 2024 - NFL

Miami Dolphins
17 :  30
Green Bay Packers

Nov 11, 2024 - NFL

Miami Dolphins
23 :  15
Los Angeles Rams

Nov 3, 2024 - NFL

Miami Dolphins
27 :  30
Buffalo Bills
Indianapolis Colts
Indianapolis Colts Latest matches
L W L W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Jan 5, 2025 - NFL

Jacksonville Jaguars
23 :  26
Indianapolis Colts

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts

Dec 15, 2024 - NFL

Indianapolis Colts
13 :  31
Denver Broncos

Dec 1, 2024 - NFL

Indianapolis Colts
25 :  24
New England Patriots

Nov 24, 2024 - NFL

Detroit Lions
24 :  6
Indianapolis Colts
W W L L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Jan 5, 2025 - NFL

Jacksonville Jaguars
23 :  26
Indianapolis Colts

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts

Nov 24, 2024 - NFL

Detroit Lions
24 :  6
Indianapolis Colts

Nov 10, 2024 - NFL

Buffalo Bills
30 :  20
Indianapolis Colts

Oct 20, 2024 - NFL

Miami Dolphins
10 :  16
Indianapolis Colts

Sep 29, 2024 - NFL

Pittsburgh Steelers
24 :  27
Indianapolis Colts
L L W W L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 15, 2024 - NFL

Indianapolis Colts
13 :  31
Denver Broncos

Dec 1, 2024 - NFL

Indianapolis Colts
25 :  24
New England Patriots

Nov 17, 2024 - NFL

Indianapolis Colts
28 :  27
New York Jets

Nov 3, 2024 - NFL

Indianapolis Colts
13 :  21
Minnesota Vikings

Oct 27, 2024 - NFL

Indianapolis Colts
20 :  23
Houston Texans

Miami Dolphins against Indianapolis Colts : Head to Head (H2H)

Oct 20, 2024 - NFL

Miami Dolphins
10 :  16
Indianapolis Colts

Miami Dolphins - Indianapolis Colts Key Points

  1. Miami is 2-8 SU in its last 10 games against Indianapolis.
  2. Miami is 2-8 SU in its last 10 games against Indianapolis.
  3. Indianapolis is 8-2 SU in its last 10 games against an opponent in the American Football Conference East
  4. Indianapolis is 5-1 ATS in its last 6 games played in September.

Our Miami Dolphins vs Indianapolis Colts Prediction

Like most projections for this matchup, expect a back-and-forth battle between these two evenly-matched teams. The Colts are trying to win their first series-opening game for the first time in 12 years, and they are pinning their hopes on their newly acquired quarterback, Daniel Jones, to end the curse. Jones, who put up encouraging numbers in the preseason, will have dynamic wide receivers in Tyler Warren and Josh Downs, who can really deal heavy damage if they are utilized properly.

On the other hand, the Dolphins will try to squeeze out any good stuff left from veteran and former Pro Bowl wideout Tyreek Hill. The 31-year-old wideout looks to create more magic with Miami quarterback Tua Tagovailoa, who is trying to bounce back from a disappointing 2024 season campaign.

The Colts' defense is shaping up to be really good this year, or even better, depending on the performance of the personnel they added to soup up their secondary. Tagavailoa can still make the Dolphins a dangerous team if he finds his elite form back this season. However, I really believe that Daniel Jones will shine in Week 1, especially if he finds a way to find his weapons downfield.

Our betting prediction for the Indianapolis Colts vs. Miami Dolphins: the Colts will win.

Prediction:

 

The Colts will win

-108
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Miami Dolphins vs Indianapolis Colts Picks