Miami Dolphins vs Buffalo Bills Prediction & Picks - NFL

USA - NFL

Miami Dolphins
9/18/25 20:15
Buffalo Bills

Prediction:

 

UNDER 49.5

-110
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 by Travis Pulver in NFL Picks

The Miami Dolphins will head to upstate New York for Thursday Night Football and a date with the Buffalo Bills. Kickoff for this AFC East division battle will kickoff at 8:15 p.m. EST at Highmark Stadium in Orchard Park, NY. The game will be broadcast/streamed on Prime Video.

Buffalo is off to a strong start this season after recording an amazing come-from-behind win over Baltimore. The game wasn’t nearly as thrilling in Week Two, but the Bills still did what mattered most vs. the Jets—they won. As for Miami, it has been a different story. The Dolphins couldn’t do anything right against the Colts in Week 12, losing 33-8. Although Tua Tagovailoa threw for over 300 passing yards in Week 2 against the Patriots, the team still lost. The Bills were gashed by the Ravens' passing game in Week 1, but the Jets were unable to exploit any gaps in coverage. However, if Tua can get the passing game on track, he has some talented playmakers who could make this game more challenging than expected.

Both teams have several players listed as questionable on the injury report, but no one is expected to miss.


 

Miami Dolphins vs Buffalo Bills Form

Table

Teams % P W D L
2
Buffalo Bills
Buffalo Bills
1 2 2 0 0
27
Miami Dolphins
Miami Dolphins
0 2 0 0 2

Miami Dolphins and Buffalo Bills Latest Matches

Miami Dolphins
Miami Dolphins Latest matches
L W W L L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 14, 2025 - NFL

New England Patriots
33 :  27
Miami Dolphins

Sep 7, 2025 - NFL

Miami Dolphins
8 :  33
Indianapolis Colts

Jan 5, 2025 - NFL

Miami Dolphins
20 :  32
New York Jets

Dec 29, 2024 - NFL

Miami Dolphins
20 :  3
Cleveland Browns

Dec 22, 2024 - NFL

San Francisco 49ers
17 :  29
Miami Dolphins

Dec 15, 2024 - NFL

Miami Dolphins
12 :  20
Houston Texans
L W W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 14, 2025 - NFL

New England Patriots
33 :  27
Miami Dolphins

Dec 22, 2024 - NFL

San Francisco 49ers
17 :  29
Miami Dolphins

Dec 8, 2024 - NFL

New York Jets
26 :  32
Miami Dolphins

Nov 24, 2024 - NFL

New England Patriots
15 :  34
Miami Dolphins

Nov 17, 2024 - NFL

Las Vegas Raiders
19 :  34
Miami Dolphins

Oct 27, 2024 - NFL

Arizona Cardinals
28 :  27
Miami Dolphins
W L L W L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 7, 2025 - NFL

Miami Dolphins
8 :  33
Indianapolis Colts

Jan 5, 2025 - NFL

Miami Dolphins
20 :  32
New York Jets

Dec 29, 2024 - NFL

Miami Dolphins
20 :  3
Cleveland Browns

Dec 15, 2024 - NFL

Miami Dolphins
12 :  20
Houston Texans

Nov 28, 2024 - NFL

Miami Dolphins
17 :  30
Green Bay Packers

Nov 11, 2024 - NFL

Miami Dolphins
23 :  15
Los Angeles Rams
Buffalo Bills
Buffalo Bills Latest matches
L W W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 14, 2025 - NFL

Buffalo Bills
30 :  10
New York Jets

Sep 7, 2025 - NFL

Baltimore Ravens
40 :  41
Buffalo Bills

Jan 26, 2025 - NFL

Buffalo Bills
29 :  32
Kansas City Chiefs

Jan 19, 2025 - NFL

Baltimore Ravens
25 :  27
Buffalo Bills

Jan 12, 2025 - NFL

Denver Broncos
7 :  31
Buffalo Bills

Jan 5, 2025 - NFL

Buffalo Bills
16 :  23
New England Patriots
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 7, 2025 - NFL

Baltimore Ravens
40 :  41
Buffalo Bills

Jan 19, 2025 - NFL

Baltimore Ravens
25 :  27
Buffalo Bills

Jan 12, 2025 - NFL

Denver Broncos
7 :  31
Buffalo Bills

Dec 29, 2024 - NFL

New York Jets
14 :  40
Buffalo Bills

Dec 22, 2024 - NFL

New England Patriots
21 :  24
Buffalo Bills

Dec 1, 2024 - NFL

San Francisco 49ers
10 :  35
Buffalo Bills
W L W L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 14, 2025 - NFL

Buffalo Bills
30 :  10
New York Jets

Jan 26, 2025 - NFL

Buffalo Bills
29 :  32
Kansas City Chiefs

Jan 5, 2025 - NFL

Buffalo Bills
16 :  23
New England Patriots

Dec 15, 2024 - NFL

Buffalo Bills
48 :  42
Detroit Lions

Dec 8, 2024 - NFL

Buffalo Bills
42 :  44
Los Angeles Rams

Nov 10, 2024 - NFL

Buffalo Bills
30 :  20
Indianapolis Colts

Miami Dolphins against Buffalo Bills : Head to Head (H2H)

Miami Dolphins

17 %

Draw

0 %

Buffalo Bills

83 %

Nov 3, 2024 - NFL

Miami Dolphins
27 :  30
Buffalo Bills

Sep 12, 2024 - NFL

Buffalo Bills
31 :  10
Miami Dolphins

Jan 7, 2024 - NFL

Buffalo Bills
21 :  14
Miami Dolphins

Oct 1, 2023 - NFL

Miami Dolphins
20 :  48
Buffalo Bills

Jan 15, 2023 - NFL

Miami Dolphins
31 :  34
Buffalo Bills

Dec 2, 2018 - NFL

Buffalo Bills
17 :  21
Miami Dolphins

Miami Dolphins - Buffalo Bills Key Points

  1. Miami leads the all-time series vs. 62-60-1.
  2. Buffalo has won six in a row and 13 of the last 14 vs. the Dolphins.
  3. The Bills have not lost to the Dolphins at home since 2016.
  4. Betting Public: In early betting, 98% of moneyline tickets are on the Bills, but only 59% of spread tickets.

Our Miami Dolphins vs Buffalo Bills Prediction

Buffalo will win this game, or at least they should. Josh Allen is already in midseason form, and the run game is getting there, too. Miami, on the other hand, doesn’t look too good. They look like a team that doesn’t have a prayer of covering a 12.5-point spread. However, the Bills are 2-9 ATS in their last 11 games where they were double-digit favorites. Four of the last six games between these two were decided by one score. The Bills will probably crush the Dolphins, but the spread is too big. However, I don’t see Miami scoring much, if at all, which will help keep the score relatively low.

Our Buffalo vs. Miami Pick: UNDER 49.5

Prediction:

 

UNDER 49.5

-110
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Miami Dolphins vs Buffalo Bills Picks