Kansas City Chiefs vs Buffalo Bills Prediction & Picks - NFL

USA - NFL

Kansas City Chiefs
11/2/25 16:25
Buffalo Bills

Prediction:

 

Bills ML

+116
$300 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Travis Pulver in NFL Picks

The Kansas City Chiefs will try to extend their winning streak to four in a row when they head to the Empire State this week to face the Buffalo Bills at Highmark Stadium in Orchard Park, NY. Kickoff for this AFC battle is scheduled for 4:25 p.m. EST, and the game will be broadcast on CBS.

This may be the most anticipated game of the regular season. For most of the season, it has appeared as though the Chiefs’ dominance may be coming to an end, following less-than-stellar performances in several games. In light of last season's offensive struggles, it did not look promising. But then they got Xavier Worthy and Rashee Rice back, spurring a three-game winning streak. However, to be fair, the win over the Lions is the only respectable one; dominating the Raiders is not hard to do, and the Commanders were without Jayden Daniels. But if they were to beat the Bills…As for Buffalo, James Cook carried them to a win last week against the Panthers to end a two-game losing streak. The defense has struggled against the run, but they were able to keep Chuba Hubbard and Rico Dowdle from breaking out. Buffalo’s defense will have its work cut out for it against a resurgent Kansas City offense.

Kansas City Chiefs vs Buffalo Bills Form

Table

Teams % P W D L
10
Buffalo Bills
Buffalo Bills
0.714 7 5 0 2
13
Kansas City Chiefs
Kansas City Chiefs
0.625 8 5 0 3

Kansas City Chiefs and Buffalo Bills Latest Matches

Kansas City Chiefs
Kansas City Chiefs Latest matches
L W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 27, 2025 - NFL

Washington Commanders
7 :  28
Kansas City Chiefs

Oct 19, 2025 - NFL

Las Vegas Raiders
0 :  31
Kansas City Chiefs

Oct 12, 2025 - NFL

Detroit Lions
17 :  30
Kansas City Chiefs

Oct 6, 2025 - NFL

Kansas City Chiefs
28 :  31
Jacksonville Jaguars

Sep 28, 2025 - NFL

Baltimore Ravens
20 :  37
Kansas City Chiefs

Sep 21, 2025 - NFL

Kansas City Chiefs
22 :  9
New York Giants
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 27, 2025 - NFL

Washington Commanders
7 :  28
Kansas City Chiefs

Oct 19, 2025 - NFL

Las Vegas Raiders
0 :  31
Kansas City Chiefs

Oct 12, 2025 - NFL

Detroit Lions
17 :  30
Kansas City Chiefs

Sep 28, 2025 - NFL

Baltimore Ravens
20 :  37
Kansas City Chiefs

Sep 14, 2025 - NFL

Philadelphia Eagles
20 :  17
Kansas City Chiefs

Jan 26, 2025 - NFL

Buffalo Bills
29 :  32
Kansas City Chiefs
W L L L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Oct 6, 2025 - NFL

Kansas City Chiefs
28 :  31
Jacksonville Jaguars

Sep 21, 2025 - NFL

Kansas City Chiefs
22 :  9
New York Giants

Sep 5, 2025 - NFL

Kansas City Chiefs
21 :  27
Los Angeles Chargers

Feb 9, 2025 - NFL

Kansas City Chiefs
22 :  40
Philadelphia Eagles

Jan 5, 2025 - NFL

Kansas City Chiefs
0 :  38
Denver Broncos

Dec 25, 2024 - NFL

Kansas City Chiefs
29 :  10
Pittsburgh Steelers
Buffalo Bills
Buffalo Bills Latest matches
W W W W L L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 26, 2025 - NFL

Buffalo Bills
40 :  9
Carolina Panthers

Oct 13, 2025 - NFL

Buffalo Bills
14 :  24
Atlanta Falcons

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills

Sep 28, 2025 - NFL

New Orleans Saints
19 :  31
Buffalo Bills

Sep 18, 2025 - NFL

Miami Dolphins
21 :  31
Buffalo Bills

Sep 14, 2025 - NFL

Buffalo Bills
30 :  10
New York Jets
W W W W W L
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills

Sep 28, 2025 - NFL

New Orleans Saints
19 :  31
Buffalo Bills

Sep 18, 2025 - NFL

Miami Dolphins
21 :  31
Buffalo Bills

Sep 7, 2025 - NFL

Baltimore Ravens
40 :  41
Buffalo Bills

Jan 19, 2025 - NFL

Baltimore Ravens
25 :  27
Buffalo Bills

Jan 12, 2025 - NFL

Denver Broncos
7 :  31
Buffalo Bills
L W L L W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 26, 2025 - NFL

Buffalo Bills
40 :  9
Carolina Panthers

Oct 13, 2025 - NFL

Buffalo Bills
14 :  24
Atlanta Falcons

Sep 14, 2025 - NFL

Buffalo Bills
30 :  10
New York Jets

Jan 26, 2025 - NFL

Buffalo Bills
29 :  32
Kansas City Chiefs

Jan 5, 2025 - NFL

Buffalo Bills
16 :  23
New England Patriots

Dec 15, 2024 - NFL

Buffalo Bills
48 :  42
Detroit Lions

Kansas City Chiefs against Buffalo Bills : Head to Head (H2H)

Kansas City Chiefs

50 %

Draw

0 %

Buffalo Bills

50 %

Jan 26, 2025 - NFL

Buffalo Bills
29 :  32
Kansas City Chiefs

Nov 17, 2024 - NFL

Kansas City Chiefs
21 :  30
Buffalo Bills

Jan 21, 2024 - NFL

Kansas City Chiefs
27 :  24
Buffalo Bills

Dec 10, 2023 - NFL

Buffalo Bills
20 :  17
Kansas City Chiefs

Oct 16, 2022 - NFL

Buffalo Bills
24 :  20
Kansas City Chiefs

Jan 24, 2021 - NFL

Buffalo Bills
24 :  38
Kansas City Chiefs

Kansas City Chiefs - Buffalo Bills: Form Analysis

Kansas City Chiefs

Fans are understandably excited about Xavier Worthy returning to the lineup a couple of weeks ago and Rashee Rice making his first start last week after serving a suspension, but the Chiefs will be without a key player in this game —running back Isiah Pacheco. The team's bread and butter is still the passing game, but the threat of a respectable rushing attack helps keep defenses honest and not going all out to rush Mahomes. Kareem Hunt will probably take over the lead back role.

Kansas City Chiefs & Buffalo Bills Squad Analysis

Buffalo Bills

The defense has taken a hit over the last week due to injuries, with Ed Oliver being placed on IR, and Shaq Thompson (LB) and Daquan Jones (DT) being ruled out this week. Wide receiver Joshua Palmer has been ruled out for Sunday as well.  

Kansas City Chiefs - Buffalo Bills Key Points

  1. Buffalo leads the all-time series against Kansas City 30-26-1; the Chiefs have won two of the last three, but the two teams are 5-5 in their last ten meetings.
  2. Buffalo is 3-4 ATS; Kansas City is 5-3 ATS.
  3. The OVER is 5-3 for the Bills and 3-5 for the Chiefs.
  4. Betting Public: 54% of moneyline tickets and 86% of the handle are on the Chiefs.

Our Kansas City Chiefs vs Buffalo Bills Prediction

This is a tough one. It is hard not to think that the Chiefs are back to their dominant ways, but I’m not ready to sign off on their return to dominance after three wins, with only one being against a good team. I’ve got a little more faith in Josh Allen and James Cook getting the job done at home than I do in the Chiefs' offense at the moment. As a home dog, I can’t pass the Bills up.

Our Kansas City vs. Buffalo Pick: Bills ML

Prediction:

 

Bills ML

+116
$300 offered for betting!

Kansas City Chiefs vs Buffalo Bills - Other Interesting Picks

Josh Allen, Anytime Touchdown

Odds +105

Allen and the Bills have no problem calling his number when the Buffalo offense gets within striking distance. He had two last week against the Panthers and has had one in each of his last four games vs. the Chiefs. KC does not have a great run defense, so there is a good chance the Bills try to take advantage of it. It's surprising to see this market at plus money odds, making it hard to pass this one up.

$300 offered for betting!

Grab an extra $300 for your Kansas City Chiefs vs Buffalo Bills wager!

Bet $5, Get $300

Get ready to experience the thrill of the game with FanDuel's exciting welcome offer, available for use on the Kansas City Chiefs vs Buffalo Bills matchup!

A minimum bet of $5 will qualify for $300 in bonus bets if your bet wins! This offer is a golden opportunity for new users. Don't miss out on this limited-time deal to enhance your sports betting experience with some extra oomph! Jump into the action today and let FanDuel take your sports engagement to the next level!

$300 available for Kansas City Chiefs vs Buffalo Bills

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Kansas City Chiefs vs Buffalo Bills Picks