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by Matt Lowrimore in NFL Picks
Another one of the games on the Week 4 Sunday NFL slate will see the San Francisco 49ers take on the Jacksonville Jaguars. Let’s take a look at the match statistics and predictions for this game between the 49ers and the Jaguars.
Jacksonville enters this game with a record of 2-1, having beaten the Houston Texans in Week 3 by a score of 17-10. The Jaguars’ offense had a total of 291 yards, while its defense allowed 271 yards. Quarterback Trevor Lawrence threw for 222 yards and one interception, while running back Travis Etienne Jr. led the team in rushing with 56 yards and one touchdown.
As for San Francisco, they enter this game with a record of 3-0, having beaten the Arizona Cardinals in Week 3 by a score of 16-15. The 49ers’ offense had a total of 355 yards, while its defense allowed 260 yards. Quarterback Mac Jones threw for 284 yards, one touchdown, and one interception, while running back Christian McCaffrey led the team in rushing with 52 yards.
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Jacksonville Jaguars vs San Francisco 49ers Form
Table
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1 | 3 | 3 | 0 | 0 |
14
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0.667 | 3 | 2 | 0 | 1 |
Jacksonville Jaguars and San Francisco 49ers Latest Matches

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Jacksonville Jaguars against San Francisco 49ers : Head to Head (H2H)
Nov 12, 2023 - NFL
Jacksonville Jaguars - San Francisco 49ers Key Points
- Jacksonville is 2-1 ATS this season
- Jacksonville is averaging 23.3 points per game this season
- San Francisco is 2-1 ATS this season
- San Francisco is averaging 19.7 points per game this season
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Our Jacksonville Jaguars vs San Francisco 49ers Prediction
San Francisco may be undefeated, but they have not played like an unbeaten team. The 49ers now have two of their quarterbacks on the injury report, that being Brock Purdy and Mac Jones. Both guys are listed as questionable for this game against Jacksonville, so it is unclear who will start for the 49ers.
Additionally, Nick Bosa tore his ACL for the 49ers and is not out for the season, further crippling their defense. Jacksonville, on the other hand, has not looked perfect, but has still found a way to win two of its three games. The Jaguars’ defense has allowed just 17.0 points per game, so given the uncertainty at quarterback for San Francisco, our San Francisco 49ers vs Jacksonville Jaguars prediction is: Jacksonville Jaguars +3.5.Jackpot Pools
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