Iowa Hawkeyes vs USC Trojans Prediction & Picks - NCAA

USA - NCAA

Iowa Hawkeyes
11/15/25 15:30
USC Trojans

Prediction:

 

UNDER 49

-110
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 by Travis Pulver in NCAA Picks

The No. 17 USC Trojans will try to remain undefeated at home this weekend when they host the No. 21 Iowa Hawkeyes at the Los Angeles Memorial Coliseum in LA, CA. Kickoff for this Big Ten battle is scheduled for 3:30 p.m. EST. Fans can catch the action once the game gets underway on the Big Ten Network.

Iowa will come into the game fresh off its second Big Ten loss after losing a close one to Oregon at home, 18-16. They managed to hold the Ducks' offense to a single touchdown early on and even took a 16-15 lead late in the game after quarterback Mark Gronowski ran one in from three yards out. But the defense couldn’t hold the Ducks' offense back as Oregon moved into place to kick the game-winning field goal with three seconds left. As for the Trojans, USC won its second in a row after taking a loss against Notre Dame with a 38-17 win over Northwestern. Jayden Maiava had a good day,  going 24-33 for 299 yards, two touchdowns, and an interception. King Miller led a rushing attack that gained 173 yards and scored three times, with 127 yards and a touchdown on 15 carries.

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Iowa Hawkeyes vs USC Trojans Form

Table

Teams % P W D L
4
USC Trojans
USC Trojans
0.833 6 5 0 1
6
Iowa Hawkeyes
Iowa Hawkeyes
0.667 6 4 0 2

Iowa Hawkeyes and USC Trojans Latest Matches

Iowa Hawkeyes
Iowa Hawkeyes Latest matches
W L W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 8, 2025 - NCAA

Oregon Ducks
18 :  16
Iowa Hawkeyes

Oct 25, 2025 - NCAA

Minnesota Golden Gophers
3 :  41
Iowa Hawkeyes

Oct 18, 2025 - NCAA

Penn State Nittany Lions
24 :  25
Iowa Hawkeyes

Oct 11, 2025 - NCAA

Iowa Hawkeyes
37 :  0
Wisconsin Badgers

Sep 27, 2025 - NCAA

Indiana Hoosiers
20 :  15
Iowa Hawkeyes

Sep 19, 2025 - NCAA

Iowa Hawkeyes
38 :  28
Rutgers Scarlet Knights
W W L W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 8, 2025 - NCAA

Oregon Ducks
18 :  16
Iowa Hawkeyes

Oct 25, 2025 - NCAA

Minnesota Golden Gophers
3 :  41
Iowa Hawkeyes

Oct 18, 2025 - NCAA

Penn State Nittany Lions
24 :  25
Iowa Hawkeyes

Sep 27, 2025 - NCAA

Indiana Hoosiers
20 :  15
Iowa Hawkeyes

Sep 13, 2025 - NCAA

UMass Minutemen
7 :  47
Iowa Hawkeyes

Aug 30, 2025 - NCAA

University At Albany Great Danes
7 :  34
Iowa Hawkeyes
L W L L W W
Victories

3/5 (60%)

Draw

0/5 (0%)

Defeats

2/5 (40%)

Oct 11, 2025 - NCAA

Iowa Hawkeyes
37 :  0
Wisconsin Badgers

Sep 19, 2025 - NCAA

Iowa Hawkeyes
38 :  28
Rutgers Scarlet Knights

Sep 6, 2025 - NCAA

Iowa Hawkeyes
13 :  16
Iowa State Cyclones

Dec 30, 2024 - NCAA Division I, FBS, Playoffs

Iowa Hawkeyes
24 :  27
Missouri Tigers

Nov 23, 2024 - NCAA

Iowa Hawkeyes
29 :  13
Maryland Terrapins
USC Trojans
USC Trojans Latest matches
W L W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 7, 2025 - NCAA

Northwestern Wildcats
17 :  38
USC Trojans

Nov 1, 2025 - NCAA

USC Trojans
21 :  17
Nebraska Cornhuskers

Oct 18, 2025 - NCAA

USC Trojans
24 :  34
Notre Dame Fighting Irish

Oct 11, 2025 - NCAA

Michigan Wolverines
13 :  31
USC Trojans

Sep 27, 2025 - NCAA

USC Trojans
32 :  34
Illinois Fighting Illini

Sep 20, 2025 - NCAA

Michigan State Spartans
31 :  45
USC Trojans
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 7, 2025 - NCAA

Northwestern Wildcats
17 :  38
USC Trojans

Oct 11, 2025 - NCAA

Michigan Wolverines
13 :  31
USC Trojans

Sep 20, 2025 - NCAA

Michigan State Spartans
31 :  45
USC Trojans

Sep 6, 2025 - NCAA

Georgia Southern Eagles
20 :  59
USC Trojans

Aug 30, 2025 - NCAA

Missouri State Bears
13 :  73
USC Trojans

Dec 27, 2024 - NCAA Division I, FBS, Playoffs

Texas AM Aggies
31 :  35
USC Trojans
L W W L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 1, 2025 - NCAA

USC Trojans
21 :  17
Nebraska Cornhuskers

Oct 18, 2025 - NCAA

USC Trojans
24 :  34
Notre Dame Fighting Irish

Sep 27, 2025 - NCAA

USC Trojans
32 :  34
Illinois Fighting Illini

Sep 13, 2025 - NCAA

USC Trojans
33 :  17
Purdue Boilermakers

Nov 23, 2024 - NCAA

USC Trojans
19 :  13
UCLA Bruins

Sep 21, 2024 - NCAA

USC Trojans
24 :  27
Michigan Wolverines

Iowa Hawkeyes - USC Trojans Key Points

  1. USC leads the all-time series vs. Iowa 7-3, but the Hawkeyes won the last meeting, 49-24 in the 2019 Holliday Bowl.
  2. Iowa is 6-2-1 ATS while USC is 5-4 ATS.
  3. The OVER is 5-4 for USC and 4-5 for Iowa.
  4. Betting Public: 28% of TOTAL tickets and 48% of the handle are on the UNDER.
Up to $250 to bet on Iowa Hawkeyes - USC Trojans! 

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Our Iowa Hawkeyes vs USC Trojans Prediction

Iowa does not have much of an offense, but that’s nothing new. But their defense is one of the best in the country (No. 4 in total offense and in points allowed). It will keep Iowa in the game and within seven points, but Iowa and the points (+6.5) is not the best bet of the day for this low-scoring game.

Our Iowa vs. USC Pick: UNDER 49

Prediction:

 

UNDER 49

-110
$250 offered for betting!

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Iowa Hawkeyes vs USC Trojans Picks