Indianapolis Colts vs Tennessee Titans Prediction & Picks - NFL

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Indianapolis Colts
9/21/25 13:00
Tennessee Titans

Prediction:

 

Indianapolis Colts ML

-198
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 by Matt Lowrimore in NFL Picks

One of the many games on the week 2 NFL slate will see the Indianapolis Colts take on the Tennessee Titans. Let’s take a look at the match statistics and predictions for this game between the Titans and the Colts.

Indianapolis enters this game with a record of 2-0, having most recently beaten the Denver Broncos in Week 2 by a score of 29-28. The Colts’ offense had a total of 473 yards, while its defense allowed 324 yards. Quarterback Daniel Jones threw for 316 yards and one touchdown, while running back Jonathan Taylor led the team in rushing with 165 yards.

As for Tennessee, they enter this game with a record of 0-2, having most recently lost to the Los Angeles Rams in Week 2 by a score of 33-19. The Titans’ offense had a total of 252 yards, while its defense allowed 439 yards. Quarterback Cam Ward threw for 175 yards and one touchdown, while running back Tony Pollard led the team in rushing with 92 yards.

Indianapolis Colts vs Tennessee Titans Form

Table

Teams % P W D L
7
Indianapolis Colts
Indianapolis Colts
1 2 2 0 0
30
Tennessee Titans
Tennessee Titans
0 2 0 0 2

Indianapolis Colts and Tennessee Titans Latest Matches

Indianapolis Colts
Indianapolis Colts Latest matches
L W L W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 14, 2025 - NFL

Denver Broncos
28 :  29
Indianapolis Colts

Sep 7, 2025 - NFL

Miami Dolphins
8 :  33
Indianapolis Colts

Jan 5, 2025 - NFL

Jacksonville Jaguars
23 :  26
Indianapolis Colts

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts

Dec 15, 2024 - NFL

Indianapolis Colts
13 :  31
Denver Broncos
L L W W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 14, 2025 - NFL

Denver Broncos
28 :  29
Indianapolis Colts

Sep 7, 2025 - NFL

Miami Dolphins
8 :  33
Indianapolis Colts

Jan 5, 2025 - NFL

Jacksonville Jaguars
23 :  26
Indianapolis Colts

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts

Nov 24, 2024 - NFL

Detroit Lions
24 :  6
Indianapolis Colts

Nov 10, 2024 - NFL

Buffalo Bills
30 :  20
Indianapolis Colts
L L W W L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 15, 2024 - NFL

Indianapolis Colts
13 :  31
Denver Broncos

Dec 1, 2024 - NFL

Indianapolis Colts
25 :  24
New England Patriots

Nov 17, 2024 - NFL

Indianapolis Colts
28 :  27
New York Jets

Nov 3, 2024 - NFL

Indianapolis Colts
13 :  21
Minnesota Vikings

Oct 27, 2024 - NFL

Indianapolis Colts
20 :  23
Houston Texans
Tennessee Titans
Tennessee Titans Latest matches
L L L L L L
Victories

0/6 (0%)

Draw

0/6 (0%)

Defeats

6/6 (100%)

Sep 14, 2025 - NFL

Los Angeles Rams
33 :  19
Tennessee Titans

Sep 7, 2025 - NFL

Tennessee Titans
12 :  20
Denver Broncos

Jan 5, 2025 - NFL

Houston Texans
23 :  14
Tennessee Titans

Dec 29, 2024 - NFL

Tennessee Titans
13 :  20
Jacksonville Jaguars

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts

Dec 15, 2024 - NFL

Cincinnati Bengals
37 :  27
Tennessee Titans
W L L L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 14, 2025 - NFL

Los Angeles Rams
33 :  19
Tennessee Titans

Jan 5, 2025 - NFL

Houston Texans
23 :  14
Tennessee Titans

Dec 15, 2024 - NFL

Cincinnati Bengals
37 :  27
Tennessee Titans

Dec 8, 2024 - NFL

Jacksonville Jaguars
10 :  6
Tennessee Titans

Nov 17, 2024 - NFL

Minnesota Vikings
23 :  13
Tennessee Titans

Nov 3, 2024 - NFL

New England Patriots
17 :  20
Tennessee Titans
L W L L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 7, 2025 - NFL

Tennessee Titans
12 :  20
Denver Broncos

Dec 29, 2024 - NFL

Tennessee Titans
13 :  20
Jacksonville Jaguars

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts

Dec 1, 2024 - NFL

Tennessee Titans
19 :  42
Washington Commanders

Nov 24, 2024 - NFL

Tennessee Titans
32 :  27
Houston Texans

Nov 10, 2024 - NFL

Tennessee Titans
17 :  27
Los Angeles Chargers

Indianapolis Colts against Tennessee Titans : Head to Head (H2H)

Indianapolis Colts

100 %

Draw

0 %

Tennessee Titans

0 %

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts

Oct 13, 2024 - NFL

Indianapolis Colts
20 :  17
Tennessee Titans

Dec 3, 2023 - NFL

Indianapolis Colts
31 :  28
Tennessee Titans

Oct 8, 2023 - NFL

Tennessee Titans
16 :  23
Indianapolis Colts

Indianapolis Colts - Tennessee Titans Key Points

  1. The Titans are 1-1 ATS this season
  2. The Titans are averaging 15.5 points per game this season
  3. The Colts are 2-0 ATS this season
  4. The Colts are averaging 31.0 points per game this season

Our Indianapolis Colts vs Tennessee Titans Prediction

Indianapolis has been a surprise team in the NFL, even two weeks into the season. This is largely due to the fact that quarterback Daniel Jones has been extremely effective. Add Jonathan Taylor as a running back to help balance the offense, and the Colts could continue their success against a bottom-tier Tennessee team.

Speaking of, the Titans may have drafted Cam Ward, but he has not looked sharp in his first two games. Granted, he is a rookie, but the Titans clearly do not have the talent around him to succeed. 

Tennessee’s struggles are likely going to continue before they improve; therefore, our Tennessee Titans vs Indianapolis Colts prediction is: Indianapolis Colts ML.

Prediction:

 

Indianapolis Colts ML

-198
$400+ offered for betting!

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Indianapolis Colts vs Tennessee Titans Picks