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Indianapolis Colts vs Los Angeles Chargers Prediction & Picks - NFL

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Indianapolis Colts
10/19/25 16:05
Los Angeles Chargers

Prediction:

 

Indianapolis +1.5

-110
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 by Bill Christy in NFL Picks

One of the best games forecasted for this weekend will take place during the later portion of Sunday when the Los Angeles Chargers (4-2) host the Indianapolis Colts (5-1). Daniel Jones has found a home in Indy after coming from the Giants where he never looked comfortable. Now, he is playing like an early MVP candidate and leading this Colts offense that leads the NFL in scoring with 32.3 points per game. Not to be outdone, the defense is holding its own as well and holding opponents to just 19.3 points per game which is 4th best in the NFL. The offense is going to be truly tested this weekend when they face a Charger defense that is 12th in the NFL and allowing just 20.8 points per game. Both teams are getting it done through the air and are currently ranked #6 and #7 in passing offense. Not many would have thought a Daniel Jones versus Justin Herbert matchup would be one that many would have been excited to see coming off last season, but here we are. Will the Chargers be able to slow down this high-powered Colts offense, or will the Colts defense stifle Herbert and company enough to allow the offense to take a week off? Time will tell in what should be an entertaining late slate game this Sunday.
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Indianapolis Colts vs Los Angeles Chargers Form

Table

Teams % P W D L
1
Indianapolis Colts
Indianapolis Colts
0.857 7 6 0 1
15
Los Angeles Chargers
Los Angeles Chargers
0.571 7 4 0 3

Indianapolis Colts and Los Angeles Chargers Latest Matches

Indianapolis Colts
Indianapolis Colts Latest matches
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 12, 2025 - NFL

Arizona Cardinals
27 :  31
Indianapolis Colts

Oct 5, 2025 - NFL

Las Vegas Raiders
6 :  40
Indianapolis Colts

Sep 28, 2025 - NFL

Indianapolis Colts
20 :  27
Los Angeles Rams

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Sep 14, 2025 - NFL

Denver Broncos
28 :  29
Indianapolis Colts

Sep 7, 2025 - NFL

Miami Dolphins
8 :  33
Indianapolis Colts
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Oct 12, 2025 - NFL

Arizona Cardinals
27 :  31
Indianapolis Colts

Oct 5, 2025 - NFL

Las Vegas Raiders
6 :  40
Indianapolis Colts

Sep 14, 2025 - NFL

Denver Broncos
28 :  29
Indianapolis Colts

Sep 7, 2025 - NFL

Miami Dolphins
8 :  33
Indianapolis Colts

Jan 5, 2025 - NFL

Jacksonville Jaguars
23 :  26
Indianapolis Colts

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts
W W L L W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 28, 2025 - NFL

Indianapolis Colts
20 :  27
Los Angeles Rams

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 15, 2024 - NFL

Indianapolis Colts
13 :  31
Denver Broncos

Dec 1, 2024 - NFL

Indianapolis Colts
25 :  24
New England Patriots

Nov 17, 2024 - NFL

Indianapolis Colts
28 :  27
New York Jets
Los Angeles Chargers
Los Angeles Chargers Latest matches
W W W L L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 12, 2025 - NFL

Los Angeles Chargers
29 :  27
Miami Dolphins

Oct 5, 2025 - NFL

Washington Commanders
27 :  10
Los Angeles Chargers

Sep 28, 2025 - NFL

Los Angeles Chargers
18 :  21
New York Giants

Sep 21, 2025 - NFL

Denver Broncos
20 :  23
Los Angeles Chargers

Sep 15, 2025 - NFL

Los Angeles Chargers
20 :  9
Las Vegas Raiders

Sep 5, 2025 - NFL

Kansas City Chiefs
21 :  27
Los Angeles Chargers
L L W W W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 5, 2025 - NFL

Washington Commanders
27 :  10
Los Angeles Chargers

Sep 21, 2025 - NFL

Denver Broncos
20 :  23
Los Angeles Chargers

Sep 5, 2025 - NFL

Kansas City Chiefs
21 :  27
Los Angeles Chargers

Dec 19, 2024 - NFL

Denver Broncos
27 :  34
Los Angeles Chargers

Dec 15, 2024 - NFL

Tampa Bay Buccaneers
40 :  17
Los Angeles Chargers

Nov 25, 2024 - NFL

Baltimore Ravens
30 :  23
Los Angeles Chargers
W W L W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 12, 2025 - NFL

Los Angeles Chargers
29 :  27
Miami Dolphins

Sep 28, 2025 - NFL

Los Angeles Chargers
18 :  21
New York Giants

Sep 15, 2025 - NFL

Los Angeles Chargers
20 :  9
Las Vegas Raiders

Jan 11, 2025 - NFL

Los Angeles Chargers
12 :  32
Houston Texans

Jan 5, 2025 - NFL

Los Angeles Chargers
34 :  20
Las Vegas Raiders

Dec 28, 2024 - NFL

Los Angeles Chargers
40 :  7
New England Patriots

Indianapolis Colts against Los Angeles Chargers : Head to Head (H2H)

Dec 26, 2022 - NFL

Los Angeles Chargers
20 :  3
Indianapolis Colts

Indianapolis Colts - Los Angeles Chargers Key Points

  1. Indianapolis is 6-1 SU in its last 7 games.
  2. Indianapolis is 8-3 SU in its last 11 games played on a Sunday.
  3. Indianapolis is 9-3 ATS in its last 12 games played in week 7.
  4. Los Angeles is 1-5 ATS in its last 6 games played in week 7.
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Our Indianapolis Colts vs Los Angeles Chargers Prediction

Both offenses could put up points and while the total is tempting to take, we are going to shy away and back what we believe is the most complete team currently in the NFL. The Colts’ defense has looked good but is the ability of the offense to dominate through the air or on the ground that has been most impressive. We believe they are going to take whatever the Chargers give them this weekend. If they take away the passing game, watch for Jonathan Taylor to have a big game on the ground. Either way, the Colts will get it done once again here.

Prediction:

 

Indianapolis +1.5

-110
$300+ offered for betting!

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Indianapolis Colts vs Los Angeles Chargers Picks
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