Detroit Lions vs Los Angeles Rams Prediction & Picks - NFL

USA - NFL

Detroit Lions
12/14/25 16:25
Los Angeles Rams

Prediction:

 

The LA Rams -5.5 points

-118
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Lou Aguila in NFL Picks

Matthew Stafford and the Los Angeles Rams will host Jared Goff and the Detroit Lions in a crucial match-up on Sunday at SoFi Stadium.

The Rams are -270 favorites against the Lions, who are 11-3 in their last 14 games on the road.

Current Form:

The 10-3 Rams are in a two-way tie with the Seahawks for the No.1 spot in the NFC West. Los Angeles has won 7 of its last 8 games, including a 45-17 rout of the Arizona Cardinals. For the third consecutive time and fifth in the last six games, Stafford threw over 200 passing yards as he passed for 281 yards with three touchdowns to spearhead the Rams’ offense. LA also flexed its lockdown defense, hounding the Cardinals to 314 total yards and 17 points.

The Lions are 8-5 in the NFC North, two games behind the division-leading Green Bay Packers (9-3) and a game below the Chicago Bears (9-4). Detroit shot down the Dallas Cowboys, 44-33, last week behind a suffocating defense and dynamic performance from the rushing crew. Jahmyr Gibbs ran for 43 yards on 12 carries with three scores, while David Montgomery covered 60 passing yards with one TD.

Up to $200 to bet on Detroit Lions - Los Angeles Rams! 

Limited Offer. Currently at DraftKings

Detroit Lions vs Los Angeles Rams Form

Table

Teams % P W D L
3
Los Angeles Rams
Los Angeles Rams
0.769 13 10 0 3
14
Detroit Lions
Detroit Lions
0.615 13 8 0 5

Detroit Lions and Los Angeles Rams Latest Matches

Detroit Lions
Detroit Lions Latest matches
L W L W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Dec 4, 2025 - NFL

Dallas Cowboys
30 :  44
Detroit Lions

Nov 27, 2025 - NFL

Green Bay Packers
31 :  24
Detroit Lions

Nov 23, 2025 - NFL

New York Giants
27 :  34
Detroit Lions

Nov 16, 2025 - NFL

Detroit Lions
9 :  16
Philadelphia Eagles

Nov 9, 2025 - NFL

Detroit Lions
44 :  22
Washington Commanders

Nov 2, 2025 - NFL

Minnesota Vikings
27 :  24
Detroit Lions
W W L W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 4, 2025 - NFL

Dallas Cowboys
30 :  44
Detroit Lions

Nov 27, 2025 - NFL

Green Bay Packers
31 :  24
Detroit Lions

Nov 23, 2025 - NFL

New York Giants
27 :  34
Detroit Lions

Nov 2, 2025 - NFL

Minnesota Vikings
27 :  24
Detroit Lions

Oct 20, 2025 - NFL

Tampa Bay Buccaneers
9 :  24
Detroit Lions

Sep 28, 2025 - NFL

Cleveland Browns
10 :  34
Detroit Lions
L W W L W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 16, 2025 - NFL

Detroit Lions
9 :  16
Philadelphia Eagles

Nov 9, 2025 - NFL

Detroit Lions
44 :  22
Washington Commanders

Oct 12, 2025 - NFL

Detroit Lions
17 :  30
Kansas City Chiefs

Oct 5, 2025 - NFL

Detroit Lions
37 :  24
Cincinnati Bengals

Sep 22, 2025 - NFL

Detroit Lions
38 :  30
Baltimore Ravens

Sep 7, 2025 - NFL

Detroit Lions
13 :  27
Green Bay Packers
Los Angeles Rams
Los Angeles Rams Latest matches
W W W W L W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Dec 7, 2025 - NFL

Los Angeles Rams
45 :  17
Arizona Cardinals

Nov 30, 2025 - NFL

Los Angeles Rams
28 :  31
Carolina Panthers

Nov 23, 2025 - NFL

Tampa Bay Buccaneers
7 :  34
Los Angeles Rams

Nov 16, 2025 - NFL

Seattle Seahawks
19 :  21
Los Angeles Rams

Nov 9, 2025 - NFL

Los Angeles Rams
42 :  26
San Francisco 49ers

Nov 2, 2025 - NFL

New Orleans Saints
10 :  34
Los Angeles Rams
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 23, 2025 - NFL

Tampa Bay Buccaneers
7 :  34
Los Angeles Rams

Nov 16, 2025 - NFL

Seattle Seahawks
19 :  21
Los Angeles Rams

Nov 2, 2025 - NFL

New Orleans Saints
10 :  34
Los Angeles Rams

Oct 2, 2025 - NFL

San Francisco 49ers
26 :  23
Los Angeles Rams

Sep 28, 2025 - NFL

Indianapolis Colts
20 :  27
Los Angeles Rams

Sep 7, 2025 - NFL

Houston Texans
9 :  14
Los Angeles Rams
L W W W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 7, 2025 - NFL

Los Angeles Rams
45 :  17
Arizona Cardinals

Nov 30, 2025 - NFL

Los Angeles Rams
28 :  31
Carolina Panthers

Nov 9, 2025 - NFL

Los Angeles Rams
42 :  26
San Francisco 49ers

Oct 19, 2025 - NFL

Los Angeles Rams
35 :  7
Jacksonville Jaguars

Oct 12, 2025 - NFL

Los Angeles Rams
17 :  3
Baltimore Ravens

Sep 21, 2025 - NFL

Los Angeles Rams
26 :  33
Philadelphia Eagles

Detroit Lions against Los Angeles Rams : Head to Head (H2H)

Detroit Lions

100 %

Draw

0 %

Los Angeles Rams

0 %

Sep 8, 2024 - NFL

Los Angeles Rams
20 :  26
Detroit Lions

Jan 14, 2024 - NFL

Los Angeles Rams
23 :  24
Detroit Lions

Detroit Lions - Los Angeles Rams Key Points

  1. Detroit is 2-4 ATS in its last 6 games.
  2. Detroit is 8-4 SU in its last 12 games.
  3. LA Rams is 15-5 ATS in its last 20 games.
  4. LA Rams is 4-1 ATS in its last 6 home games
Up to $200 to bet on Detroit Lions - Los Angeles Rams! 

Limited Offer. Currently at DraftKings

Our Detroit Lions vs Los Angeles Rams Prediction

Fearless Forecast: The Rams are 5-1 at home this season and 7-1 SU in their last 8 games. Detroit has defeated Los Angeles in their last two meetings, but the Rams are flying right now, thanks to the brilliance of Matthew Stafford. This is not going to be an easy game for the Rams because the Lions can punish teams by creating turnovers.

Still, I don’t think Detroit has enough ammunition to take down the Rams, who are 15-5 against the spread in their last 20 games. The Rams are 4-2 against the spread in their six home games this season. The Lions are 3-3 ATS in their six road games and 2-4 ATS in their last 6 games.

Our betting prediction for the Detroit Lions vs. the LA Rams: The Los Angeles Rams -5.5 points

Prediction:

 

The LA Rams -5.5 points

-118
$200 offered for betting!

Claim $200 for your Detroit Lions vs Los Angeles Rams wager!

DK Welcome Bonus

Would you like to bet on Detroit Lions vs Los Angeles Rams? For this NFL match, DK treats you to an exclusive offer: a bonus of $200, no promo code needed! Take advantage while you still can!

Not registered yet? You can create your account now with our link below. A bonus of $200 awaits you on the Detroit Lions vs Los Angeles Rams match!

$200 available for Detroit Lions vs Los Angeles Rams

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Detroit Lions vs Los Angeles Rams Picks