Seattle Seahawks vs Indianapolis Colts Prediction & Picks - NFL

USA - NFL

Seattle Seahawks
12/14/25 16:25
Indianapolis Colts

Prediction:

 

Colts ML

+100
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Travis Pulver | in NFL Picks

The Indianapolis Colts (8-5) will have a tough time ending their losing streak at three when they head to the Pacific Northwest this week to face the Seattle Seahawks (10-3). Kickoff at Lumen Field in Seattle, WA, is scheduled for 4:25 p.m. EST with coverage provided by CBS.

Indianapolis had been struggling heading into last week’s game vs. the Jaguars, having lost two in a row. But when Daniel Jones went down with what was later discovered to be a season-ending injury, things went from bad to worse. Undrafted rookie and former Notre Dame quarterback Riley Leonard took over, and it is safe to say things did not go well. To top it off, Leonard got injured, putting his status in question for this week. Enter former Hall of Fame semifinalist and one-time Colts QB Phillip Rivers. Despite not having played in five years, the Colts worked him out, signed him, and there is a strong chance he starts this week. As for Seattle, the Seahawks have won three in a row and seven of their last eight (the one loss, 21-19 vs. the Rams on the road). Sam Darnold and the offense have been playing well, but the defense has really stepped up the last couple of weeks with a shutout vs. Minnesota and holding the Falcons to just nine points.

Seattle Seahawks vs Indianapolis Colts Form

Table

Teams Pts P W L
1 Seattle Seahawks
0.824 17 14 3
20 Indianapolis Colts
0.471 17 8 9

Seattle Seahawks and Indianapolis Colts Latest Matches

Seattle Seahawks
Seattle Seahawks Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 7, 2025 - NFL

Atlanta Falcons
9 :  37
Seattle Seahawks

Nov 30, 2025 - NFL

Seattle Seahawks
26 :  0
Minnesota Vikings

Nov 23, 2025 - NFL

Tennessee Titans
24 :  30
Seattle Seahawks

Nov 16, 2025 - NFL

Los Angeles Rams
21 :  19
Seattle Seahawks

Nov 9, 2025 - NFL

Seattle Seahawks
44 :  22
Arizona Cardinals

Nov 2, 2025 - NFL

Washington Commanders
14 :  38
Seattle Seahawks
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 30, 2025 - NFL

Seattle Seahawks
26 :  0
Minnesota Vikings

Nov 9, 2025 - NFL

Seattle Seahawks
44 :  22
Arizona Cardinals

Oct 20, 2025 - NFL

Seattle Seahawks
27 :  19
Houston Texans

Oct 5, 2025 - NFL

Seattle Seahawks
35 :  38
Tampa Bay Buccaneers

Sep 21, 2025 - NFL

Seattle Seahawks
44 :  13
New Orleans Saints

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 7, 2025 - NFL

Atlanta Falcons
9 :  37
Seattle Seahawks

Nov 23, 2025 - NFL

Tennessee Titans
24 :  30
Seattle Seahawks

Nov 16, 2025 - NFL

Los Angeles Rams
21 :  19
Seattle Seahawks

Nov 2, 2025 - NFL

Washington Commanders
14 :  38
Seattle Seahawks

Oct 12, 2025 - NFL

Jacksonville Jaguars
12 :  20
Seattle Seahawks

Sep 25, 2025 - NFL

Arizona Cardinals
20 :  23
Seattle Seahawks
Indianapolis Colts
Indianapolis Colts Latest matches
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Dec 7, 2025 - NFL

Jacksonville Jaguars
36 :  19
Indianapolis Colts

Nov 30, 2025 - NFL

Indianapolis Colts
16 :  20
Houston Texans

Nov 23, 2025 - NFL

Kansas City Chiefs
23 :  20
Indianapolis Colts

Nov 9, 2025 - NFL

Indianapolis Colts
31 :  25
Atlanta Falcons

Nov 2, 2025 - NFL

Pittsburgh Steelers
27 :  20
Indianapolis Colts

Oct 26, 2025 - NFL

Indianapolis Colts
38 :  14
Tennessee Titans
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 30, 2025 - NFL

Indianapolis Colts
16 :  20
Houston Texans

Nov 9, 2025 - NFL

Indianapolis Colts
31 :  25
Atlanta Falcons

Oct 26, 2025 - NFL

Indianapolis Colts
38 :  14
Tennessee Titans

Oct 12, 2025 - NFL

Indianapolis Colts
31 :  27
Arizona Cardinals

Oct 5, 2025 - NFL

Indianapolis Colts
40 :  6
Las Vegas Raiders

Sep 14, 2025 - NFL

Indianapolis Colts
29 :  28
Denver Broncos
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Dec 7, 2025 - NFL

Jacksonville Jaguars
36 :  19
Indianapolis Colts

Nov 23, 2025 - NFL

Kansas City Chiefs
23 :  20
Indianapolis Colts

Nov 2, 2025 - NFL

Pittsburgh Steelers
27 :  20
Indianapolis Colts

Oct 19, 2025 - NFL

Los Angeles Chargers
24 :  38
Indianapolis Colts

Sep 28, 2025 - NFL

Los Angeles Rams
27 :  20
Indianapolis Colts

Sep 21, 2025 - NFL

Tennessee Titans
20 :  41
Indianapolis Colts

Seattle Seahawks - Indianapolis Colts Key Points

  1. Indianapolis leads the all-time series vs. Seattle 7-6, but the two teams have not played since the 2021 season.
  2. Phillip Rivers is 3-1 vs. the Seahawks with all four games played with the Chargers; the last was in 2018.
  3. Phillip Rivers has gone 137-107 as a starting quarterback.
  4. Betting Public: 10% of moneyline tickets and 57% of the handle are on the Colts.

Our Seattle Seahawks vs Indianapolis Colts Prediction

With how well the Seahawks have been playing of late, it is hard to get behind the Colts to win this one outright. With how Riley Leonard looked in limited time last week, it is hard to see him keeping this one close. Theoretically, a Phillip Rivers-led offense shouldn’t have a shot either. It doesn’t help that the newly acquired Sauce Gardner is out as well. But Rivers has been great in the past; he was a Hall of Fame semifinalist before signing with the Colts. If he can rediscover the old magic, he could make this a competitive game, and the defense can step up. This could be a competitive game.

Our Colts vs. Seahawks Pick: Colts +14

Prediction:

 

Colts ML

+100
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Seattle Seahawks vs Indianapolis Colts Picks