San Francisco 49ers vs Tennessee Titans Prediction & Picks - NFL

USA - NFL

San Francisco 49ers
12/14/25 16:25
Tennessee Titans

Prediction:

 

The Titans +12.5 points

-110
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 by Lou Aguila | in NFL Picks

The San Francisco 49ers will have a -12.5 points handicap when they take on the Tennessee Titans on Sunday at Levi’s Stadium.

The 49ers are 4-1 against the spread in their last five games.

Current Form:

The 49ers will try to stay in the hunt for the NFC West title as they go for their fourth consecutive win and 10th win of the season against the skidding Titans. At 9-4, San Francisco trails both the Los Angeles Chargers and the Seattle Hawks, who both carry identical 9-3 records. After a rough start, Brock Purdy has accumulated 1,147 yards with 9 touchdowns and 7 interceptions. The 49ers will need another big game from Purdy to get past the Titans, who are the third-worst defensive team at 27.5 points allowed per game.

The Titans ended their seven-game losing streak after edging the Cleveland Browns, 31-29. Cam Ward only threw 117 yards, but he scored two touchdowns in this game. Running back Tony Pollard was deadly in the red zone, rushing for 161 yards on 25 yards with two touchdowns. Tennessee is 2-17 SU in its last 19 games.

San Francisco 49ers vs Tennessee Titans Form

Table

Teams Pts P W L
7 San Francisco 49ers
0.706 17 12 5
32 Tennessee Titans
0.176 17 3 14

San Francisco 49ers and Tennessee Titans Latest Matches

San Francisco 49ers
San Francisco 49ers Latest matches
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 30, 2025 - NFL

Cleveland Browns
8 :  26
San Francisco 49ers

Nov 24, 2025 - NFL

San Francisco 49ers
20 :  9
Carolina Panthers

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Nov 9, 2025 - NFL

San Francisco 49ers
26 :  42
Los Angeles Rams

Nov 2, 2025 - NFL

New York Giants
24 :  34
San Francisco 49ers

Oct 26, 2025 - NFL

Houston Texans
26 :  15
San Francisco 49ers
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 24, 2025 - NFL

San Francisco 49ers
20 :  9
Carolina Panthers

Nov 9, 2025 - NFL

San Francisco 49ers
26 :  42
Los Angeles Rams

Oct 19, 2025 - NFL

San Francisco 49ers
20 :  10
Atlanta Falcons

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 30, 2025 - NFL

Cleveland Browns
8 :  26
San Francisco 49ers

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Nov 2, 2025 - NFL

New York Giants
24 :  34
San Francisco 49ers

Oct 26, 2025 - NFL

Houston Texans
26 :  15
San Francisco 49ers

Oct 12, 2025 - NFL

Tampa Bay Buccaneers
30 :  19
San Francisco 49ers

Oct 2, 2025 - NFL

Los Angeles Rams
23 :  26
San Francisco 49ers
Tennessee Titans
Tennessee Titans Latest matches
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Dec 7, 2025 - NFL

Cleveland Browns
29 :  31
Tennessee Titans

Nov 30, 2025 - NFL

Tennessee Titans
3 :  25
Jacksonville Jaguars

Nov 23, 2025 - NFL

Tennessee Titans
24 :  30
Seattle Seahawks

Nov 16, 2025 - NFL

Tennessee Titans
13 :  16
Houston Texans

Nov 2, 2025 - NFL

Tennessee Titans
20 :  27
Los Angeles Chargers

Oct 26, 2025 - NFL

Indianapolis Colts
38 :  14
Tennessee Titans
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Nov 30, 2025 - NFL

Tennessee Titans
3 :  25
Jacksonville Jaguars

Nov 23, 2025 - NFL

Tennessee Titans
24 :  30
Seattle Seahawks

Nov 16, 2025 - NFL

Tennessee Titans
13 :  16
Houston Texans

Nov 2, 2025 - NFL

Tennessee Titans
20 :  27
Los Angeles Chargers

Oct 19, 2025 - NFL

Tennessee Titans
13 :  31
New England Patriots

Sep 21, 2025 - NFL

Tennessee Titans
20 :  41
Indianapolis Colts
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Dec 7, 2025 - NFL

Cleveland Browns
29 :  31
Tennessee Titans

Oct 26, 2025 - NFL

Indianapolis Colts
38 :  14
Tennessee Titans

Oct 12, 2025 - NFL

Las Vegas Raiders
20 :  10
Tennessee Titans

Oct 5, 2025 - NFL

Arizona Cardinals
21 :  22
Tennessee Titans

Sep 28, 2025 - NFL

Houston Texans
26 :  0
Tennessee Titans

Sep 7, 2025 - NFL

Denver Broncos
20 :  12
Tennessee Titans
San Francisco 49ers vs Tennessee Titans Picks

San Francisco 49ers - Tennessee Titans Key Points

  1. Tennessee is 8-1-1 ATS in its last 10 games against San Francisco.
  2. Tennessee is 4-1 ATS in its last 5 games.
  3. San Francisco is 2-5 ATS in its last 7 games at home.
  4. San Francisco is 0-4-1 ATS in its last 5 games when playing at home against Tennessee.

Our San Francisco 49ers vs Tennessee Titans Prediction

Fearless Forecast: Get me the Titans to cover the +12.5-point spread against the 49ers. Tennessee is 4-1 ATS in its last five games and 8-1-1 ATS in its last 10 games against San Francisco. Tony Pollard is expected to deliver another electric performance after torching the Browns’ defense last week. The 49ers are no doubt a rock-solid pick to win straight-up, yet the trends in their head-to-head series are all pointing towards Tennessee putting up a strong fight on Sunday.

Our betting prediction for the Tennessee Titans vs. the San Francisco 49ers: The Titans +12.5 points

Prediction:

 

The Titans +12.5 points

-110
$1000 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.