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by Lou Aguila in NFL Picks
Division rivals, the Green Bay Packers and the Detroit Lions, lock horns in Week 1 of the 2025 NFL season. Bookmakers anticipate a tight ball game this Sunday at Lambeau Field, listing the home team as slight -130 favorites.
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After losing their first preseason game to the New York Jets 10-30, the Packers rebounded with strong wins over the Indianapolis Colts 23-19 and the Seattle Seahawks 20-7 to finish their preseason schedule with a 2-1 record. It looks like this year’s Packers will still be a formidable defensive team. Boasting the 6th fewest points allowed in the NFL last season (19.9 points), the Packers hounded the Seahawks to just seven points in their final preseason games. The offense will only improve this year with Jordan Love aiming for his first Pro Bowl season after two productive seasons with the Packers.
The Lions finished the preseason with a 1-2 record after losing their last two exhibition matches against the Miami Dolphins 17-24 and the Houston Texans 7-26. Their only win came in Week 1 against the Atlanta Falcons 17-10. Quarterback Jared Goff looks to put the Lions in a position to win lots of games and perhaps contend for a Super Bowl title after they got upset by the Washington Commanders in the divisional playoffs last year.
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Detroit Lions vs Green Bay Packers Form
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Teams | % | P | W | D | L |
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1 | 1 | 1 | 0 | 0 |
24
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0 | 1 | 0 | 0 | 1 |
Detroit Lions and Green Bay Packers Latest Matches

4/6 (67%)
0/6 (0%)
2/6 (33%)
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4/6 (67%)
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6/6 (100%)
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2/6 (33%)
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4/6 (67%)
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4/6 (67%)
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3/6 (50%)
0/6 (0%)
3/6 (50%)
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Detroit Lions against Green Bay Packers : Head to Head (H2H)
67 %
0 %
33 %
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Detroit Lions - Green Bay Packers Key Points
- Green Bay is 1-5 ATS in its last 6 games against an opponent in the National Football Conference North division.
- Green Bay is 2-4 SU in its last 6 games.
- Detroit is 14-2 SU in its last 16 games.
- Detroit is 8-0 SU in its last 8 games on the road.
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Our Detroit Lions vs Green Bay Packers Prediction
Much like what the bookmakers are expecting, I am also predicting a close week 1 battle between these two bitter rivals in the NFC North. ESPN Match Predictor only gives the Packers a 49.9 percent win probability to take down the Lions at Lambeau Field, while most of the sportsbooks – including Caesars Sportsbook – have the Packers set as slight favorites.
Green Bay, which carries a 10-4 record in its last 14 games at home, is a solid moneyline pick. However, reports are circulating that starting quarterback Jordan Love might not be available for this Week 1 matchup because of a thumb injury. He did participate in practice, though, but will the injury have some impact on his performance against the Lions? Defensive end Micah Parsons is expected to play on Sunday, but in a limited capacity because of an injury. It’s not looking good right now for the Packers.
On the other hand, you’ve got the Lions in full force, looking to send a message to their rival and the rest of the NFL. Detroit is 8-0 SU in its last 8 games on the road and 12-4 ATS in its last 16 games against Green Bay. The numbers and trends are firmly on the side of the Lions.
Our betting prediction for the Green Bay Packers vs. the Detroit Lions: the Lions will win.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

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