Carolina Panthers vs New England Patriots Prediction & Picks - NFL

USA - NFL

Carolina Panthers
9/28/25 13:00
New England Patriots

Prediction:

 

Over 43.5

-104
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 by Erik Gibbs | in NFL Picks

The North Carolina Panthers travel north to Foxboro for an interconference matchup against the New England Patriots, with both teams sitting at 1-2 on the season. Carolina comes in with some momentum after securing its first win of the year, a dominant 30-0 home victory over the Atlanta Falcons.

Quarterback Bryce Young accounted for a rushing score while managing 121 passing yards, showing poise in a game where the defense dictated the tempo. The Panthers will be eager to build on that breakthrough performance as they look for consistency on both sides of the ball.

New England, meanwhile, is searching for answers. The Patriots are also 1-2 after dropping a 23-17 home game to the Pittsburgh Steelers, continuing a frustrating trend of struggling in Foxboro. Over their last 19 contests, the Patriots have dropped 15, a reflection of an offense that has not been able to finish drives.

While rookie quarterback Drake Maye has shown accuracy and promise with a 72.6 percent completion rate and five touchdowns through three weeks, New England has still managed to score 14 points or fewer in two of its first three games.

Carolina Panthers vs New England Patriots Form

Table

Teams % P W D L
19
New England Patriots
New England Patriots
0.5 4 2 0 2
26
Carolina Panthers
Carolina Panthers
0.25 4 1 0 3

Carolina Panthers and New England Patriots Latest Matches

Carolina Panthers
Carolina Panthers Latest matches
W L W L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 21, 2025 - NFL

Atlanta Falcons
0 :  30
Carolina Panthers

Sep 14, 2025 - NFL

Carolina Panthers
22 :  27
Arizona Cardinals

Sep 7, 2025 - NFL

Carolina Panthers
10 :  26
Jacksonville Jaguars

Jan 5, 2025 - NFL

Carolina Panthers
44 :  38
Atlanta Falcons

Dec 29, 2024 - NFL

Carolina Panthers
14 :  48
Tampa Bay Buccaneers

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers
W L L L W W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 21, 2025 - NFL

Atlanta Falcons
0 :  30
Carolina Panthers

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Dec 15, 2024 - NFL

Dallas Cowboys
30 :  14
Carolina Panthers

Dec 1, 2024 - NFL

Tampa Bay Buccaneers
26 :  23
Carolina Panthers

Nov 24, 2024 - NFL

Kansas City Chiefs
30 :  27
Carolina Panthers

Nov 10, 2024 - NFL

New York Giants
17 :  20
Carolina Panthers
L L L W L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 14, 2025 - NFL

Carolina Panthers
22 :  27
Arizona Cardinals

Sep 7, 2025 - NFL

Carolina Panthers
10 :  26
Jacksonville Jaguars

Jan 5, 2025 - NFL

Carolina Panthers
44 :  38
Atlanta Falcons

Dec 29, 2024 - NFL

Carolina Panthers
14 :  48
Tampa Bay Buccaneers

Dec 8, 2024 - NFL

Carolina Panthers
16 :  22
Philadelphia Eagles

Oct 27, 2024 - NFL

Carolina Panthers
14 :  28
Denver Broncos
New England Patriots
New England Patriots Latest matches
L L W L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 21, 2025 - NFL

Pittsburgh Steelers
21 :  14
New England Patriots

Sep 14, 2025 - NFL

New England Patriots
33 :  27
Miami Dolphins

Sep 7, 2025 - NFL

Las Vegas Raiders
20 :  13
New England Patriots

Jan 5, 2025 - NFL

Buffalo Bills
16 :  23
New England Patriots

Dec 28, 2024 - NFL

Los Angeles Chargers
40 :  7
New England Patriots

Dec 22, 2024 - NFL

New England Patriots
21 :  24
Buffalo Bills
L L L W L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 21, 2025 - NFL

Pittsburgh Steelers
21 :  14
New England Patriots

Sep 7, 2025 - NFL

Las Vegas Raiders
20 :  13
New England Patriots

Jan 5, 2025 - NFL

Buffalo Bills
16 :  23
New England Patriots

Dec 28, 2024 - NFL

Los Angeles Chargers
40 :  7
New England Patriots

Dec 1, 2024 - NFL

Indianapolis Colts
25 :  24
New England Patriots

Nov 17, 2024 - NFL

Los Angeles Rams
28 :  22
New England Patriots
L W L L L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 14, 2025 - NFL

New England Patriots
33 :  27
Miami Dolphins

Dec 22, 2024 - NFL

New England Patriots
21 :  24
Buffalo Bills

Dec 15, 2024 - NFL

New England Patriots
17 :  30
Arizona Cardinals

Nov 24, 2024 - NFL

New England Patriots
15 :  34
Miami Dolphins

Nov 10, 2024 - NFL

New England Patriots
19 :  3
Chicago Bears

Nov 3, 2024 - NFL

New England Patriots
17 :  20
Tennessee Titans

Carolina Panthers - New England Patriots Key Points

  1. The Panthers are 1-14 in their last 15 road games on the East Coast
  2. The underdogs are 3-1 in the Patriots’ last four games
  3. The Panthers are 0-4 ATS in their last four games vs. AFC East teams
  4. The Patriots are 0-8 ATS in their last eight September home games

Our Carolina Panthers vs New England Patriots Prediction

Statistically, Carolina has its share of challenges. The Panthers rank 19th in points per game, 25th in rushing, and 24th in passing. Yet the offensive line has been effective in protection, allowing the eighth-fewest sacks so far. Their red zone efficiency remains middle-of-the-pack at 18th, but the defense has been a stabilizing factor, currently sitting 8th in the league in points allowed per game. That balance gives them a chance to be competitive against a New England squad that has yet to establish rhythm on either side of the ball.

On the Patriots' side, their defense has bent against the pass, and their offense has been plagued by stalling drives and missed opportunities in scoring situations. The inability to convert has left them vulnerable, especially at home, where they have not claimed victory as a favorite since September 2023. Maye will need support from his receivers and a stronger ground game if the Patriots are to overcome a Panthers team riding high off its first shutout win in nearly a decade.

This clash feels like it could tilt either way, but Carolina’s defense gives them an edge against an inconsistent Patriots attack. If Bryce Young avoids mistakes and the Panthers’ pass rush continues to pressure opposing quarterbacks, Carolina has a strong chance to leave Foxboro with back-to-back wins. Expect a close, low-scoring battle, but the Panthers appear slightly better positioned to come out on top. Our prediction for New England Patriots vs. Carolina Panthers: Over 43.5 points. 

Prediction:

 

Over 43.5

-104
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Carolina Panthers vs New England Patriots Picks