Buffalo Bills vs New England Patriots Prediction & Picks - NFL

USA - NFL

Buffalo Bills
12/14/25 13:00
New England Patriots

Prediction:

 

Over 248.5.

-110
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 by Carlos Zabala in NFL Picks

The Bills managed to defeat the Bengals in a thrilling game last week, securing their ninth win of the season. The Bills secured their ninth win of the season by defeating the Bengals by a score of 39-34 in a snowy Highmark Stadium; Buffalo secured the victory in the final moments with a play that garnered significant attention. Brentford, in an impractical fashion, intercepted Burrow's soft pass and executed a 63-yard pick-6. Josh Allen had an outstanding day, throwing three touchdown passes for the Bills and running for another for himself.

In the NFL Week 15 betting odds, there's no matchup closer than the Bills-Patriots. The 11-2 Pats are slight underdogs at Gillette Stadium; a win for New England would clinch their first division title of the decade.

The formidable Patriots have won each of their last 10 games, had a bye last week, and then defeated the Giants 33-15 in Week 13.

Drake Maye, the New England quarterback, continues to have an epic season. Against the Giants, he completed 24 of 31 passes for 282 yards and two touchdowns.

Buffalo Bills vs New England Patriots Form

Table

Teams % P W D L
2
New England Patriots
New England Patriots
0.846 13 11 0 2
8
Buffalo Bills
Buffalo Bills
0.692 13 9 0 4

Buffalo Bills and New England Patriots Latest Matches

Buffalo Bills
Buffalo Bills Latest matches
W L W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 7, 2025 - NFL

Cincinnati Bengals
34 :  39
Buffalo Bills

Nov 30, 2025 - NFL

Buffalo Bills
26 :  7
Pittsburgh Steelers

Nov 20, 2025 - NFL

Buffalo Bills
19 :  23
Houston Texans

Nov 16, 2025 - NFL

Tampa Bay Buccaneers
32 :  44
Buffalo Bills

Nov 9, 2025 - NFL

Buffalo Bills
13 :  30
Miami Dolphins

Nov 2, 2025 - NFL

Kansas City Chiefs
21 :  28
Buffalo Bills
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Dec 7, 2025 - NFL

Cincinnati Bengals
34 :  39
Buffalo Bills

Nov 16, 2025 - NFL

Tampa Bay Buccaneers
32 :  44
Buffalo Bills

Nov 2, 2025 - NFL

Kansas City Chiefs
21 :  28
Buffalo Bills

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills

Sep 28, 2025 - NFL

New Orleans Saints
19 :  31
Buffalo Bills

Sep 18, 2025 - NFL

Miami Dolphins
21 :  31
Buffalo Bills
W L W L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 30, 2025 - NFL

Buffalo Bills
26 :  7
Pittsburgh Steelers

Nov 20, 2025 - NFL

Buffalo Bills
19 :  23
Houston Texans

Nov 9, 2025 - NFL

Buffalo Bills
13 :  30
Miami Dolphins

Oct 26, 2025 - NFL

Buffalo Bills
40 :  9
Carolina Panthers

Oct 13, 2025 - NFL

Buffalo Bills
14 :  24
Atlanta Falcons

Sep 14, 2025 - NFL

Buffalo Bills
30 :  10
New York Jets
New England Patriots
New England Patriots Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Dec 1, 2025 - NFL

New York Giants
15 :  33
New England Patriots

Nov 23, 2025 - NFL

New England Patriots
26 :  20
Cincinnati Bengals

Nov 13, 2025 - NFL

New York Jets
14 :  27
New England Patriots

Nov 9, 2025 - NFL

New England Patriots
28 :  23
Tampa Bay Buccaneers

Nov 2, 2025 - NFL

Atlanta Falcons
23 :  24
New England Patriots

Oct 26, 2025 - NFL

Cleveland Browns
13 :  32
New England Patriots
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Dec 1, 2025 - NFL

New York Giants
15 :  33
New England Patriots

Nov 13, 2025 - NFL

New York Jets
14 :  27
New England Patriots

Nov 2, 2025 - NFL

Atlanta Falcons
23 :  24
New England Patriots

Oct 26, 2025 - NFL

Cleveland Browns
13 :  32
New England Patriots

Sep 28, 2025 - NFL

Carolina Panthers
13 :  42
New England Patriots

Sep 21, 2025 - NFL

Pittsburgh Steelers
21 :  14
New England Patriots
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 23, 2025 - NFL

New England Patriots
26 :  20
Cincinnati Bengals

Nov 9, 2025 - NFL

New England Patriots
28 :  23
Tampa Bay Buccaneers

Oct 19, 2025 - NFL

New England Patriots
31 :  13
Tennessee Titans

Oct 12, 2025 - NFL

New England Patriots
25 :  19
New Orleans Saints

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills

Sep 14, 2025 - NFL

New England Patriots
33 :  27
Miami Dolphins

Buffalo Bills against New England Patriots : Head to Head (H2H)

Buffalo Bills

50 %

Draw

0 %

New England Patriots

50 %

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills

Jan 5, 2025 - NFL

Buffalo Bills
16 :  23
New England Patriots

Dec 22, 2024 - NFL

New England Patriots
21 :  24
Buffalo Bills

Dec 31, 2023 - NFL

New England Patriots
21 :  27
Buffalo Bills

Oct 22, 2023 - NFL

Buffalo Bills
25 :  29
New England Patriots

Dec 28, 2020 - NFL

Buffalo Bills
38 :  9
New England Patriots

Buffalo Bills - New England Patriots Key Points

  1. The Bills are second in the NFL in total yards with 399.1
  2. The Bills lead the NFL in rushing yards per game with 157.8
  3. The Patriots have the sixth-best defense in terms of total yards allowed per game
  4. Buffalo are 3-3 on the road this season

Our Buffalo Bills vs New England Patriots Prediction

Maye's elite season has Pats fans buzzing. Comparisons to Brady are inevitable, especially since he has completed over 70% of his passes this season. He is on track to surpass the franchise record Brady set in 2007 with 68.9%.

Despite interceptions 10 times this season, Josh Allen is enjoying a very respectable season with the Bills. Therefore, a high-scoring match seems likely.

Our predictions for Bills vs Patriots are: Over 248.5.

Prediction:

 

Over 248.5.

-110
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Buffalo Bills vs New England Patriots Picks