Arizona Cardinals vs New Orleans Saints Prediction & Picks - NFL

USA - NFL

Arizona Cardinals
9/7/25 13:00
New Orleans Saints

Prediction:

 

Under 43.5 Total Points

-112
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 by Matt Lowrimore | in NFL Picks

Week 1 of the NFL is finally here, and with that, one of the matchups on the Sunday slate will see the New Orleans Saints take on the Arizona Cardinals. Let’s take a look at the match statistics and predictions for this game between the Saints and Cardinals.

Arizona enters this game coming off an 8-9 record in 2024-2025. The Cardinals finished in third place in the NFC West division, and it was the third straight season that Arizona has missed the playoffs.

As for New Orleans, they are coming off a disastrous 2024-2025 season in which they finished with a record of 5-12. The Saints finished in fourth place in the NFC South division and have now missed the playoffs for four straight years. The Saints welcome in a new head coach for the 2025-2026 season, that being Kellen Moore, in the hopes that he can lead them back to their winning ways.

Arizona Cardinals vs New Orleans Saints Form

Table

Teams % P W D L
11
Arizona Cardinals
Arizona Cardinals
1 1 1 0 0
24
New Orleans Saints
New Orleans Saints
0 1 0 0 1

Arizona Cardinals and New Orleans Saints Latest Matches

Arizona Cardinals
Arizona Cardinals Latest matches
L L W L L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Jan 5, 2025 - NFL

San Francisco 49ers
24 :  47
Arizona Cardinals

Dec 28, 2024 - NFL

Arizona Cardinals
9 :  13
Los Angeles Rams

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Dec 15, 2024 - NFL

New England Patriots
17 :  30
Arizona Cardinals

Dec 8, 2024 - NFL

Seattle Seahawks
30 :  18
Arizona Cardinals

Dec 1, 2024 - NFL

Arizona Cardinals
22 :  23
Minnesota Vikings
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Jan 5, 2025 - NFL

San Francisco 49ers
24 :  47
Arizona Cardinals

Dec 15, 2024 - NFL

New England Patriots
17 :  30
Arizona Cardinals

Dec 8, 2024 - NFL

Seattle Seahawks
30 :  18
Arizona Cardinals

Nov 10, 2024 - NFL

New York Jets
6 :  31
Arizona Cardinals

Nov 3, 2024 - NFL

Chicago Bears
9 :  29
Arizona Cardinals

Oct 21, 2024 - NFL

Los Angeles Chargers
15 :  17
Arizona Cardinals
L W L L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Dec 28, 2024 - NFL

Arizona Cardinals
9 :  13
Los Angeles Rams

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Dec 1, 2024 - NFL

Arizona Cardinals
22 :  23
Minnesota Vikings

Nov 24, 2024 - NFL

Arizona Cardinals
6 :  16
Seattle Seahawks

Oct 27, 2024 - NFL

Arizona Cardinals
28 :  27
Miami Dolphins

Oct 13, 2024 - NFL

Arizona Cardinals
13 :  34
Green Bay Packers
New Orleans Saints
New Orleans Saints Latest matches
L W L L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Jan 5, 2025 - NFL

New Orleans Saints
19 :  27
Tampa Bay Buccaneers

Dec 29, 2024 - NFL

Las Vegas Raiders
25 :  10
New Orleans Saints

Dec 23, 2024 - NFL

New Orleans Saints
0 :  34
Green Bay Packers

Dec 15, 2024 - NFL

Washington Commanders
20 :  19
New Orleans Saints

Dec 8, 2024 - NFL

New Orleans Saints
14 :  11
New York Giants

Dec 1, 2024 - NFL

Los Angeles Rams
21 :  14
New Orleans Saints
L W W L L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Dec 29, 2024 - NFL

Las Vegas Raiders
25 :  10
New Orleans Saints

Dec 15, 2024 - NFL

Washington Commanders
20 :  19
New Orleans Saints

Dec 1, 2024 - NFL

Los Angeles Rams
21 :  14
New Orleans Saints

Nov 17, 2024 - NFL

Cleveland Browns
14 :  35
New Orleans Saints

Nov 10, 2024 - NFL

Atlanta Falcons
17 :  20
New Orleans Saints

Oct 17, 2024 - NFL

Denver Broncos
33 :  10
New Orleans Saints
L L L W L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Jan 5, 2025 - NFL

New Orleans Saints
19 :  27
Tampa Bay Buccaneers

Dec 23, 2024 - NFL

New Orleans Saints
0 :  34
Green Bay Packers

Dec 8, 2024 - NFL

New Orleans Saints
14 :  11
New York Giants

Nov 3, 2024 - NFL

New Orleans Saints
22 :  23
Carolina Panthers

Oct 27, 2024 - NFL

New Orleans Saints
8 :  26
Los Angeles Chargers

Oct 7, 2024 - NFL

New Orleans Saints
13 :  26
Kansas City Chiefs

Arizona Cardinals - New Orleans Saints Key Points

  1. Arizona was 2-6 SU on the road last season
  2. New Orleans was 3-6 SU at home last season
  3. New Orleans averaged 19.9 points per game last season
  4. Arizona averaged 23.5 points per game last season

Our Arizona Cardinals vs New Orleans Saints Prediction

This is a tricky matchup, as both teams struggled to score consistently last season. New Orleans ranked 24th in scoring offense last year, averaging just 19.9 points per game. As for Arizona, they averaged 23.5 points per game and ranked 12th.

Defensively, both the Saints and Cardinals were similar, with New Orleans allowing an average of 23.4 points per game and Arizona allowing an average of 22.2 points per game.

With this being the start of a new season and the first game for the Saints under Kellen Moore, points could be at a premium, especially on the New Orleans side. For that reason, our New Orleans Saints vs Arizona Cardinals prediction is: Under 43.5 Total Points.

Prediction:

 

Under 43.5 Total Points

-112
$400+ offered for betting!

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Arizona Cardinals vs New Orleans Saints Picks