Arizona Cardinals vs Cincinnati Bengals Prediction & Picks - NFL

The Cardinals defense has been especially concerning. Over the last six games, Arizona has surrendered at least 35 points five times, an alarming trend that highlights both schematic issues and personnel limitations. While Budda Baker has been a rare bright spot with 111 combined tackles, his availability is in question due to a concussion. Without him, Arizona loses not only production but also leadership in the secondary. Statistically, the unit ranks in the bottom third of the league against both the pass and the run, leaving few areas opposing offenses need to avoid.

Cincinnati's season has also been disappointing, but the Bengals at least show signs of competitiveness. They reached their bye week with a 3-6 record, picking up wins over Cleveland, Jacksonville, and Pittsburgh. While losses followed against a variety of opponents, the Bengals have found an offensive rhythm late in the year. After the bye, Cincinnati went 1-4, but even in defeat, the offense has been more consistent. Through 14 games, the Bengals hold a 4-10 record.

Last week's performance against Miami was easily Cincinnati's most complete outing in weeks. The Bengals piled up 407 total yards, moved the chains efficiently, and protected the football. Defensively, they forced three turnovers and limited Miami's third-down success. That showing came one week after being shut out by Baltimore, making it a strong response to adversity. Cincinnati has now scored at least 32 points in three of its last four games, suggesting the offense is peaking, even if it is too late to salvage the season.

Given the current trajectories, Cincinnati holds a clear advantage. The Bengals are healthier, more productive on offense, and coming off a confidence-boosting win. Arizona, meanwhile, continues to leak points and yards while juggling injuries and inconsistency. Unless the Cardinals can force turnovers early or control the tempo in unexpected ways, this matchup sets up as an opportunity for Cincinnati to dictate play and close out the game without much resistance. Our prediction for Cincinnati Bengals vs. Arizona Cardinals: Under 52.5 points.