Indiana Hoosiers vs USC Trojans Prediction & Picks - NCAA

Prediction published on 11/12/26, 3:30 PM  by Matt Lowrimore | Modified on 11/12/26 at 3:30 PM in NCAA Picks

Plenty of games are scheduled on the Week 11 College Football Saturday slate, one of which will feature a Big Ten matchup between the 18th-ranked USC Trojans and the 9th-ranked Indiana Hoosiers. Let’s take a look at the match statistics and predictions for this game between the Trojans and the Hoosiers.

USC enters this game with a record of 7-2 and 4-2 in the Big Ten. The Trojans are coming off their bye week, having most recently upset Ohio State in Week 9 by a score of 30-18. USC has for the most part been steady this season, although their two losses have come by an average margin of 15.5 points per game. That said, the Trojans have had extra time to prepare for this game, suggesting they will be able to keep it close.

As for Indiana, they enter this game with a record of 8-1 and 5-1 in the Big Ten. The Hoosiers are coming off a 23-16 win against Minnesota in Week 10, a game where they struggled for long stretches and needed overtime to secure the win. Despite their record, Indiana has, time and time again, allowed their opponents to stay in games and has rarely won by a wide margin, a trend that looks likely to continue against USC.