Tennessee Titans vs San Francisco 49ers Prediction & Picks - NFL

USA - NFL

Tennessee Titans
12/14/25 16:25
San Francisco 49ers

Prediction:

 

The Titans +12.5 points

-110
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 by Lou Aguila in NFL Picks

The San Francisco 49ers will have a -12.5 points handicap when they take on the Tennessee Titans on Sunday at Levi’s Stadium.

The 49ers are 4-1 against the spread in their last five games.

Current Form:

The 49ers will try to stay in the hunt for the NFC West title as they go for their fourth consecutive win and 10th win of the season against the skidding Titans. At 9-4, San Francisco trails both the Los Angeles Chargers and the Seattle Hawks, who both carry identical 9-3 records. After a rough start, Brock Purdy has accumulated 1,147 yards with 9 touchdowns and 7 interceptions. The 49ers will need another big game from Purdy to get past the Titans, who are the third-worst defensive team at 27.5 points allowed per game.

The Titans ended their seven-game losing streak after edging the Cleveland Browns, 31-29. Cam Ward only threw 117 yards, but he scored two touchdowns in this game. Running back Tony Pollard was deadly in the red zone, rushing for 161 yards on 25 yards with two touchdowns. Tennessee is 2-17 SU in its last 19 games.

Tennessee Titans vs San Francisco 49ers Form

Table

Teams % P W D L
9
San Francisco 49ers
San Francisco 49ers
0.692 13 9 0 4
32
Tennessee Titans
Tennessee Titans
0.154 13 2 0 11

Tennessee Titans and San Francisco 49ers Latest Matches

Tennessee Titans
Tennessee Titans Latest matches
L L L L L W
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Dec 7, 2025 - NFL

Tennessee Titans
31 :  29
Cleveland Browns

Nov 30, 2025 - NFL

Jacksonville Jaguars
25 :  3
Tennessee Titans

Nov 23, 2025 - NFL

Seattle Seahawks
30 :  24
Tennessee Titans

Nov 16, 2025 - NFL

Houston Texans
16 :  13
Tennessee Titans

Nov 2, 2025 - NFL

Los Angeles Chargers
27 :  20
Tennessee Titans

Oct 26, 2025 - NFL

Tennessee Titans
14 :  38
Indianapolis Colts
L L L L L L
Victories

0/6 (0%)

Draw

0/6 (0%)

Defeats

6/6 (100%)

Nov 30, 2025 - NFL

Jacksonville Jaguars
25 :  3
Tennessee Titans

Nov 23, 2025 - NFL

Seattle Seahawks
30 :  24
Tennessee Titans

Nov 16, 2025 - NFL

Houston Texans
16 :  13
Tennessee Titans

Nov 2, 2025 - NFL

Los Angeles Chargers
27 :  20
Tennessee Titans

Oct 19, 2025 - NFL

New England Patriots
31 :  13
Tennessee Titans

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans
L L W L L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Dec 7, 2025 - NFL

Tennessee Titans
31 :  29
Cleveland Browns

Oct 26, 2025 - NFL

Tennessee Titans
14 :  38
Indianapolis Colts

Oct 12, 2025 - NFL

Tennessee Titans
10 :  20
Las Vegas Raiders

Oct 5, 2025 - NFL

Tennessee Titans
22 :  21
Arizona Cardinals

Sep 28, 2025 - NFL

Tennessee Titans
0 :  26
Houston Texans

Sep 7, 2025 - NFL

Tennessee Titans
12 :  20
Denver Broncos
San Francisco 49ers
San Francisco 49ers Latest matches
L W L W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 30, 2025 - NFL

San Francisco 49ers
26 :  8
Cleveland Browns

Nov 24, 2025 - NFL

Carolina Panthers
9 :  20
San Francisco 49ers

Nov 16, 2025 - NFL

San Francisco 49ers
41 :  22
Arizona Cardinals

Nov 9, 2025 - NFL

Los Angeles Rams
42 :  26
San Francisco 49ers

Nov 2, 2025 - NFL

San Francisco 49ers
34 :  24
New York Giants

Oct 26, 2025 - NFL

San Francisco 49ers
15 :  26
Houston Texans
L W L W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 24, 2025 - NFL

Carolina Panthers
9 :  20
San Francisco 49ers

Nov 9, 2025 - NFL

Los Angeles Rams
42 :  26
San Francisco 49ers

Oct 19, 2025 - NFL

Atlanta Falcons
10 :  20
San Francisco 49ers

Sep 28, 2025 - NFL

Jacksonville Jaguars
26 :  21
San Francisco 49ers

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers

Dec 30, 2024 - NFL

Detroit Lions
40 :  34
San Francisco 49ers
W L L W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 30, 2025 - NFL

San Francisco 49ers
26 :  8
Cleveland Browns

Nov 16, 2025 - NFL

San Francisco 49ers
41 :  22
Arizona Cardinals

Nov 2, 2025 - NFL

San Francisco 49ers
34 :  24
New York Giants

Oct 26, 2025 - NFL

San Francisco 49ers
15 :  26
Houston Texans

Oct 12, 2025 - NFL

San Francisco 49ers
19 :  30
Tampa Bay Buccaneers

Oct 2, 2025 - NFL

San Francisco 49ers
26 :  23
Los Angeles Rams

Tennessee Titans - San Francisco 49ers Key Points

  1. Tennessee is 8-1-1 ATS in its last 10 games against San Francisco.
  2. Tennessee is 4-1 ATS in its last 5 games.
  3. San Francisco is 2-5 ATS in its last 7 games at home.
  4. San Francisco is 0-4-1 ATS in its last 5 games when playing at home against Tennessee.

Our Tennessee Titans vs San Francisco 49ers Prediction

Fearless Forecast: Get me the Titans to cover the +12.5-point spread against the 49ers. Tennessee is 4-1 ATS in its last five games and 8-1-1 ATS in its last 10 games against San Francisco. Tony Pollard is expected to deliver another electric performance after torching the Browns’ defense last week. The 49ers are no doubt a rock-solid pick to win straight-up, yet the trends in their head-to-head series are all pointing towards Tennessee putting up a strong fight on Sunday.

Our betting prediction for the Tennessee Titans vs. the San Francisco 49ers: The Titans +12.5 points

Prediction:

 

The Titans +12.5 points

-110
$150 offered for betting!

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Tennessee Titans vs San Francisco 49ers Picks