Tennessee Titans vs Indianapolis Colts Prediction & Picks - NFL

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Tennessee Titans
10/26/25 16:25
Indianapolis Colts

Prediction:

 

Indianapolis -14.5

-110
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 by Travis Pulver in NFL Picks

The Colts (6-1) will try to keep the good times rolling this week when they host the Tennessee Titans (1-6) at Lucas Oil Stadium in Indianapolis, IN. Kickoff for this AFC South battle is scheduled for 4:25 p.m. EST and will be broadcast on CBS.

This will be the second game between these division rivals. Indianapolis won the first in Nashville back in Week 3, 41-20. Daniel Jones had an efficient day, going 18-25 for 228 yards and one touchdown (he was not sacked). He tacked on another 27 yards on the ground, where Jonathan Taylor led the way with 107 yards and three touchdowns. Cam Ward struggled to get the Titans offense on track, completing 23 of 38 pass attempts for 219 yards and a touchdown with one interception (he was sacked four times). It probably would have helped if they could have established a run game (23 carries for 86 yards and a score).

Indianapolis went on to lose its first game the following week vs. the Rams, but has since bounced back behind the play of Daniel Jones and the Colts' offense and won three in a row. Tennessee finally got a win in Week 5 vs. the Cardinals in Arizona.

Tennessee Titans vs Indianapolis Colts Form

Table

Teams % P W D L
1
Indianapolis Colts
Indianapolis Colts
0.857 7 6 0 1
30
Tennessee Titans
Tennessee Titans
0.143 7 1 0 6

Tennessee Titans and Indianapolis Colts Latest Matches

Tennessee Titans
Tennessee Titans Latest matches
L L L W L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Oct 19, 2025 - NFL

New England Patriots
31 :  13
Tennessee Titans

Oct 12, 2025 - NFL

Tennessee Titans
10 :  20
Las Vegas Raiders

Oct 5, 2025 - NFL

Tennessee Titans
22 :  21
Arizona Cardinals

Sep 28, 2025 - NFL

Tennessee Titans
0 :  26
Houston Texans

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Sep 14, 2025 - NFL

Los Angeles Rams
33 :  19
Tennessee Titans
L L L L L L
Victories

0/6 (0%)

Draw

0/6 (0%)

Defeats

6/6 (100%)

Oct 19, 2025 - NFL

New England Patriots
31 :  13
Tennessee Titans

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Sep 14, 2025 - NFL

Los Angeles Rams
33 :  19
Tennessee Titans

Jan 5, 2025 - NFL

Houston Texans
23 :  14
Tennessee Titans

Dec 15, 2024 - NFL

Cincinnati Bengals
37 :  27
Tennessee Titans

Dec 8, 2024 - NFL

Jacksonville Jaguars
10 :  6
Tennessee Titans
L L L L W L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Oct 12, 2025 - NFL

Tennessee Titans
10 :  20
Las Vegas Raiders

Oct 5, 2025 - NFL

Tennessee Titans
22 :  21
Arizona Cardinals

Sep 28, 2025 - NFL

Tennessee Titans
0 :  26
Houston Texans

Sep 7, 2025 - NFL

Tennessee Titans
12 :  20
Denver Broncos

Dec 29, 2024 - NFL

Tennessee Titans
13 :  20
Jacksonville Jaguars

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts
Indianapolis Colts
Indianapolis Colts Latest matches
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 19, 2025 - NFL

Indianapolis Colts
38 :  24
Los Angeles Chargers

Oct 12, 2025 - NFL

Arizona Cardinals
27 :  31
Indianapolis Colts

Oct 5, 2025 - NFL

Las Vegas Raiders
6 :  40
Indianapolis Colts

Sep 28, 2025 - NFL

Indianapolis Colts
20 :  27
Los Angeles Rams

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Sep 14, 2025 - NFL

Denver Broncos
28 :  29
Indianapolis Colts
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Oct 12, 2025 - NFL

Arizona Cardinals
27 :  31
Indianapolis Colts

Oct 5, 2025 - NFL

Las Vegas Raiders
6 :  40
Indianapolis Colts

Sep 14, 2025 - NFL

Denver Broncos
28 :  29
Indianapolis Colts

Sep 7, 2025 - NFL

Miami Dolphins
8 :  33
Indianapolis Colts

Jan 5, 2025 - NFL

Jacksonville Jaguars
23 :  26
Indianapolis Colts

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts
W L L W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 19, 2025 - NFL

Indianapolis Colts
38 :  24
Los Angeles Chargers

Sep 28, 2025 - NFL

Indianapolis Colts
20 :  27
Los Angeles Rams

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 15, 2024 - NFL

Indianapolis Colts
13 :  31
Denver Broncos

Dec 1, 2024 - NFL

Indianapolis Colts
25 :  24
New England Patriots

Tennessee Titans against Indianapolis Colts : Head to Head (H2H)

Tennessee Titans

0 %

Draw

0 %

Indianapolis Colts

100 %

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Dec 22, 2024 - NFL

Tennessee Titans
30 :  38
Indianapolis Colts

Oct 13, 2024 - NFL

Indianapolis Colts
20 :  17
Tennessee Titans

Dec 3, 2023 - NFL

Indianapolis Colts
31 :  28
Tennessee Titans

Oct 8, 2023 - NFL

Tennessee Titans
16 :  23
Indianapolis Colts

Tennessee Titans - Indianapolis Colts Key Points

  1. With just one loss, the Colts have the best record in the NFL.
  2. Indianapolis leads the all-time series vs. the Titans 40-22, winning the last five.
  3. The Titans last beat the Colts in Indianapolis on Oct 23 during the 2022 season.
  4. Betting Public: 62% of spread tickets and 56% of the handle are on the Colts (-14.5).

Our Tennessee Titans vs Indianapolis Colts Prediction

The Colts and Titans are operating on completely different ends of the spectrum. Indy is No. 2 in total offense; Tennessee is No.32. The Colts are No. 1 in scoring (33.1 ppg and the Titans are No. 32. Cam Ward and the Tennessee offense have improved since Week 3, but so have the Colts. The only way the Colts lose this game is if they beat themselves. Otherwise, Indianapolis will run away with this one.

Our Titans vs. Colts Pick: Indianapolis -14.5

Prediction:

 

Indianapolis -14.5

-110
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Tennessee Titans vs Indianapolis Colts Picks