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by Carlos Zabala in MLB Picks
On Monday, with veteran Verlander perhaps pitching one of the last starts of his long career, the Giants lost again, dropping eight of their last ten games, recording their 80th loss and virtually ending any playoff chances they had all season. They couldn't beat the Cardinals at Oracle Park; they ended up losing 5-6, despite Ramos hitting his 19th home run of the year and Devers hitting his 33rd HR.
The Cards, on the other hand, had a good night at the plate on Monday; this matched the Giants' record of 77-80, and St. Louis is aiming, at the very least, to achieve a winning season this year. José Fermín, playing second base and batting eighth, went 2-for-4. Burleson had an excellent game, going 3-for-5, and Panamanian Iván Herrera went 1-for-3 with two RBIs and a home run.
The Giants are the favorites on Tuesday, with odds around -180 at betting sites. The main reason for these odds is the pitching matchup: Logan Webb will pitch with a 3.27 ERA in 195.2 IP for the Giants, and Andre Pallante will pitch for the Cards, with a 6-15 record, a high 5.29 ERA, and a 6-15 record.
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St. Louis Cardinals vs San Francisco Giants Form
Table
Teams | % | P | W | L |
---|---|---|---|---|
18
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0.49 | 157 | 77 | 80 |
18
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0.49 | 157 | 77 | 80 |
St. Louis Cardinals and San Francisco Giants Latest Matches

4/6 (67%)
2/6 (33%)
Sep 22, 2025 - MLB
Sep 21, 2025 - MLB
Sep 20, 2025 - MLB
Sep 19, 2025 - MLB
Sep 17, 2025 - MLB
Sep 16, 2025 - MLB
3/6 (50%)
3/6 (50%)
Sep 21, 2025 - MLB
Sep 20, 2025 - MLB
Sep 19, 2025 - MLB
Sep 17, 2025 - MLB
Sep 16, 2025 - MLB
Sep 15, 2025 - MLB
2/6 (33%)
4/6 (67%)
Sep 22, 2025 - MLB
Sep 14, 2025 - MLB
Sep 13, 2025 - MLB
Sep 12, 2025 - MLB
Sep 10, 2025 - MLB
Sep 9, 2025 - MLB

2/6 (33%)
4/6 (67%)
Sep 22, 2025 - MLB
Sep 21, 2025 - MLB
Sep 20, 2025 - MLB
Sep 19, 2025 - MLB
Sep 18, 2025 - MLB
Sep 17, 2025 - MLB
2/6 (33%)
4/6 (67%)
Sep 22, 2025 - MLB
Sep 14, 2025 - MLB
Sep 13, 2025 - MLB
Sep 12, 2025 - MLB
Sep 10, 2025 - MLB
Sep 9, 2025 - MLB
2/6 (33%)
4/6 (67%)
Sep 21, 2025 - MLB
Sep 20, 2025 - MLB
Sep 19, 2025 - MLB
Sep 18, 2025 - MLB
Sep 17, 2025 - MLB
Sep 16, 2025 - MLB
St. Louis Cardinals against San Francisco Giants : Head to Head (H2H)
83 %
17 %
Sep 22, 2025 - MLB
Sep 7, 2025 - MLB
Sep 6, 2025 - MLB
Sep 5, 2025 - MLB
Sep 29, 2024 - MLB
Sep 27, 2024 - MLB
St. Louis Cardinals - San Francisco Giants Key Points
- The Giants' pitching allowed the fewest home runs in MLB with 137
- The Cardinals won eight of their last 10 games against the Giants
- In three of their last five games, Pallante allowed a home run
- The Giants have the second-fewest stolen bases in MLB this season
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Our St. Louis Cardinals vs San Francisco Giants Prediction
As for the betting odds, the Giants haven't always been able to justify their favorite status; in fact, their record is 30-28 as the betting favorite playing at Oracle Park.
But the Cards have been even more consistent in losing on the road when they're the betting underdogs; in that case, their record is 23-34.
Livan Webb struck out eight in 2024 the last time the Giants faced the Cardinals.
Our prediciton for Giants vs Cardinals is: Giants -1.5.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

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