Cleveland Guardians vs Detroit Tigers Prediction & Picks - MLB

Prediction published on 9/23/25, 2:58 PM  by Carlos Zabala | Modified on 9/23/25 at 9:15 PM in MLB Picks

Both the Tigers and Guardians rested on Monday, but starting Tuesday, they'll play the most epic series of the final week of MLB regular-season action.

In 2024, when the Tigers positioned themselves as midseason sellers, they also rallied in September with names like Torkelson, Carpenter, and Greene to sneak into the playoffs on the final day. Well, that's what's happening to the Guardians in 2025. On the contrary, AJ Hinch's team, while leading the AL for much of the season, is incredibly close to missing the playoffs, with a dismal September of just 5 wins, losing 9 of their last 10 games and their last 6 after being swept by the Braves in Atlanta.

Like the Tigers, the Guards lost Sunday by the same score of 2-6 against the Twins in Minneapolis, but Cleveland remains the hottest team of the moment; They've won nine of their last 10 games, taken all three games of their series against the Tigers in Detroit, and are in an unbeatable position to wrest the division title from the Tigers starting Tuesday at Progressive Field.