Cleveland Guardians vs Detroit Tigers Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
9/23/25 18:40
Detroit Tigers

Prediction:

 

Under 6.5 points

−105
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 by Carlos Zabala | in MLB Picks

Both the Tigers and Guardians rested on Monday, but starting Tuesday, they'll play the most epic series of the final week of MLB regular-season action.

In 2024, when the Tigers positioned themselves as midseason sellers, they also rallied in September with names like Torkelson, Carpenter, and Greene to sneak into the playoffs on the final day. Well, that's what's happening to the Guardians in 2025. On the contrary, AJ Hinch's team, while leading the AL for much of the season, is incredibly close to missing the playoffs, with a dismal September of just 5 wins, losing 9 of their last 10 games and their last 6 after being swept by the Braves in Atlanta.

Like the Tigers, the Guards lost Sunday by the same score of 2-6 against the Twins in Minneapolis, but Cleveland remains the hottest team of the moment; They've won nine of their last 10 games, taken all three games of their series against the Tigers in Detroit, and are in an unbeatable position to wrest the division title from the Tigers starting Tuesday at Progressive Field.

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Cleveland Guardians vs Detroit Tigers Form

Table

Teams Pts P W L
10 Cleveland Guardians
0.543 162 88 74
11 Detroit Tigers
0.537 162 87 75

Cleveland Guardians and Detroit Tigers Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 20, 2025 - MLB

Minnesota Twins
0 :  6
Cleveland Guardians

Sep 11, 2025 - MLB

Cleveland Guardians
3 :  2
Kansas City Royals

Sep 10, 2025 - MLB

Cleveland Guardians
3 :  4
Kansas City Royals

Sep 9, 2025 - MLB

Cleveland Guardians
2 :  0
Kansas City Royals

Sep 8, 2025 - MLB

Cleveland Guardians
10 :  2
Kansas City Royals

Sep 4, 2025 - MLB

Tampa Bay Rays
4 :  2
Cleveland Guardians
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 11, 2025 - MLB

Cleveland Guardians
3 :  2
Kansas City Royals

Sep 10, 2025 - MLB

Cleveland Guardians
3 :  4
Kansas City Royals

Sep 9, 2025 - MLB

Cleveland Guardians
2 :  0
Kansas City Royals

Sep 8, 2025 - MLB

Cleveland Guardians
10 :  2
Kansas City Royals

Aug 30, 2025 - MLB

Cleveland Guardians
4 :  3
Seattle Mariners

Aug 27, 2025 - MLB

Cleveland Guardians
4 :  3
Tampa Bay Rays
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 20, 2025 - MLB

Minnesota Twins
0 :  6
Cleveland Guardians

Sep 4, 2025 - MLB

Tampa Bay Rays
4 :  2
Cleveland Guardians

Sep 2, 2025 - MLB

Boston Red Sox
11 :  7
Cleveland Guardians

Sep 1, 2025 - MLB

Boston Red Sox
6 :  4
Cleveland Guardians

Aug 24, 2025 - MLB

Texas Rangers
5 :  0
Cleveland Guardians

Aug 23, 2025 - MLB

Texas Rangers
10 :  0
Cleveland Guardians
Detroit Tigers
Detroit Tigers Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 21, 2025 - MLB

Detroit Tigers
2 :  6
Atlanta Braves

Sep 20, 2025 - MLB

Detroit Tigers
5 :  6
Atlanta Braves

Sep 19, 2025 - MLB

Detroit Tigers
1 :  10
Atlanta Braves

Sep 13, 2025 - MLB

Miami Marlins
6 :  4
Detroit Tigers

Sep 12, 2025 - MLB

Miami Marlins
8 :  2
Detroit Tigers

Sep 11, 2025 - MLB

New York Yankees
9 :  3
Detroit Tigers
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 21, 2025 - MLB

Detroit Tigers
2 :  6
Atlanta Braves

Sep 20, 2025 - MLB

Detroit Tigers
5 :  6
Atlanta Braves

Sep 19, 2025 - MLB

Detroit Tigers
1 :  10
Atlanta Braves

Sep 3, 2025 - MLB

Detroit Tigers
6 :  2
New York Mets

Sep 2, 2025 - MLB

Detroit Tigers
5 :  12
New York Mets

Sep 1, 2025 - MLB

Detroit Tigers
8 :  10
New York Mets
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 13, 2025 - MLB

Miami Marlins
6 :  4
Detroit Tigers

Sep 12, 2025 - MLB

Miami Marlins
8 :  2
Detroit Tigers

Sep 11, 2025 - MLB

New York Yankees
9 :  3
Detroit Tigers

Sep 10, 2025 - MLB

New York Yankees
1 :  11
Detroit Tigers

Sep 9, 2025 - MLB

New York Yankees
2 :  12
Detroit Tigers

Aug 31, 2025 - MLB

Kansas City Royals
0 :  5
Detroit Tigers

Cleveland Guardians against Detroit Tigers : Head to Head (H2H)

Cleveland Guardians

67 %

Detroit Tigers

33 %

Jul 4, 2025 - MLB

Cleveland Guardians
1 :  2
Detroit Tigers

May 23, 2025 - MLB

Detroit Tigers
1 :  3
Cleveland Guardians

May 22, 2025 - MLB

Detroit Tigers
0 :  7
Cleveland Guardians

Oct 12, 2024 - MLB

Cleveland Guardians
7 :  3
Detroit Tigers

Oct 10, 2024 - MLB

Detroit Tigers
4 :  5
Cleveland Guardians

Oct 9, 2024 - MLB

Detroit Tigers
3 :  0
Cleveland Guardians
Cleveland Guardians vs Detroit Tigers Picks

Cleveland Guardians - Detroit Tigers Key Points

  1. Kwan hit his 11th home run of the year in the Guardians' last loss
  2. Tigers, MLB team with the fewest stolen bases this season
  3. Guards' pitching ERA is the fourth-best in MLB at 3.71.
  4. Tigers, MLB team with the 10th-most home runs this season

Our Cleveland Guardians vs Detroit Tigers Prediction

The situation couldn't be more intense, and Progressive Field is expected to be packed, even on a Tuesday. A.J. Hinch lined up his starting pitching staff to have the reigning Cy Young Award winner and probable Cy Young Award winner this season, the almost infallible Tarik Skubal, pitching Tuesday.

Nothing can be blamed on Skubal for the Tigers' slump; In fact, he is coming off a 6-inning, 102 pitches against the Guardians, with 9 strikeouts and only one earned run.

But the Guards' starting staff has also responded when the moment called for it; Gavin Williams pitched five scoreless innings against the Tigers in Detroit and hopes to do the same on Tuesday.

Our prediction for Tigers vs Guardians is: Under 6.5 runs.

Prediction:

 

Under 6.5 points

−105
$200 offered for betting!

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