Buffalo Bills vs Detroit Lions Prediction & Picks - NFL

USA - NFL

Buffalo Bills
9/17/26 20:15
Detroit Lions

Prediction:

 

Lions (+5.5) to win

-111
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 by Simon Day | in NFL Picks

Week Two of the NFL season kicks off with a blockbuster TNF clash between two of the league's most explosive offenses, as the Buffalo Bills face the Detroit Lions at Highmark Stadium.

The Bills started the season with an exciting 36-31 win over the Texans in a game that saw superstar QB Josh Allen throw for 334 yards and 2 TDs, plus add two more touchdowns on the ground. On the other side of the ball, Greg Rousseau recorded two strip sacks, the second of which resulted in a game-ending recovery from Terrel Bernard.

Detroit looked to be cruising to an opening win over the Saints after establishing a 21-0 lead in the third quarter. However, a worrying defensive collapse saw New Orleans force the game into overtime, where a failed two point conversion handed a last gasp victory to the Lions. A much-improved defensive display is needed if Detroit are to stop Josh Allen and co from running riot on Thursday night. 

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Buffalo Bills vs Detroit Lions Form

Table

Teams Pts P W L
4 Buffalo Bills
1 1 1 0
7 Detroit Lions
1 1 1 0

Buffalo Bills and Detroit Lions Latest Matches

Buffalo Bills
Buffalo Bills Latest matches
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 13, 2026 - NFL

Houston Texans
31 :  36
Buffalo Bills

Jan 17, 2026 - NFL

Denver Broncos
33 :  30
Buffalo Bills

Jan 11, 2026 - NFL

Jacksonville Jaguars
24 :  27
Buffalo Bills

Jan 4, 2026 - NFL

Buffalo Bills
35 :  8
New York Jets

Dec 28, 2025 - NFL

Buffalo Bills
12 :  13
Philadelphia Eagles

Dec 21, 2025 - NFL

Cleveland Browns
20 :  23
Buffalo Bills
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jan 4, 2026 - NFL

Buffalo Bills
35 :  8
New York Jets

Dec 28, 2025 - NFL

Buffalo Bills
12 :  13
Philadelphia Eagles

Dec 7, 2025 - NFL

Buffalo Bills
39 :  34
Cincinnati Bengals

Nov 16, 2025 - NFL

Buffalo Bills
44 :  32
Tampa Bay Buccaneers

Nov 2, 2025 - NFL

Buffalo Bills
28 :  21
Kansas City Chiefs

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 13, 2026 - NFL

Houston Texans
31 :  36
Buffalo Bills

Jan 17, 2026 - NFL

Denver Broncos
33 :  30
Buffalo Bills

Jan 11, 2026 - NFL

Jacksonville Jaguars
24 :  27
Buffalo Bills

Dec 21, 2025 - NFL

Cleveland Browns
20 :  23
Buffalo Bills

Dec 14, 2025 - NFL

New England Patriots
31 :  35
Buffalo Bills

Nov 30, 2025 - NFL

Pittsburgh Steelers
7 :  26
Buffalo Bills
Detroit Lions
Detroit Lions Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 13, 2026 - NFL

Detroit Lions
31 :  30
New Orleans Saints

Jan 4, 2026 - NFL

Chicago Bears
16 :  19
Detroit Lions

Dec 25, 2025 - NFL

Minnesota Vikings
23 :  10
Detroit Lions

Dec 21, 2025 - NFL

Detroit Lions
24 :  29
Pittsburgh Steelers

Dec 14, 2025 - NFL

Los Angeles Rams
41 :  34
Detroit Lions

Dec 4, 2025 - NFL

Detroit Lions
44 :  30
Dallas Cowboys
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 13, 2026 - NFL

Detroit Lions
31 :  30
New Orleans Saints

Dec 21, 2025 - NFL

Detroit Lions
24 :  29
Pittsburgh Steelers

Dec 4, 2025 - NFL

Detroit Lions
44 :  30
Dallas Cowboys

Nov 27, 2025 - NFL

Detroit Lions
24 :  31
Green Bay Packers

Nov 23, 2025 - NFL

Detroit Lions
34 :  27
New York Giants

Nov 2, 2025 - NFL

Detroit Lions
24 :  27
Minnesota Vikings
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jan 4, 2026 - NFL

Chicago Bears
16 :  19
Detroit Lions

Dec 25, 2025 - NFL

Minnesota Vikings
23 :  10
Detroit Lions

Dec 14, 2025 - NFL

Los Angeles Rams
41 :  34
Detroit Lions

Nov 16, 2025 - NFL

Philadelphia Eagles
16 :  9
Detroit Lions

Nov 9, 2025 - NFL

Washington Commanders
22 :  44
Detroit Lions

Oct 12, 2025 - NFL

Kansas City Chiefs
30 :  17
Detroit Lions

Buffalo Bills against Detroit Lions : Head to Head (H2H)

Buffalo Bills

100 %

Detroit Lions

0 %

Dec 15, 2024 - NFL

Detroit Lions
42 :  48
Buffalo Bills
Buffalo Bills vs Detroit Lions Picks

Buffalo Bills - Detroit Lions Key Points

  1. The last 5 Lions-Bills matchups have been decided by under 6 points
  2. Detroit have won 3 of their last 5 in Buffalo
  3. 6 of Buffalo's last 7 wins over Detoit have been by under 6 points
  4. 6 of Buffalo's last 7 games have been decided by under 8 points
Up to $250 to bet on Buffalo Bills - Detroit Lions! 

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Our Buffalo Bills vs Detroit Lions Prediction

Early season TNF matchups can be extremely hard to predict, so although the oddsmakers are making the Bills fairly strong favorites, we do think the Lions could cause a bit of an upset on Thursday night. 

Any side boasting the likes of Jared Goff, Jahmyr Gibbs and Amon-Ra St Brown is capable of going toe-to-toe with the best sides in the league. So, whilst we aren't going to predict a shock win for Detroit, we are tipping them to keep this close and beat the spread. 

Our prediction for Buffalo Bills vs Detroit Lions is: Lions (+5.5) to win

Prediction:

 

Lions (+5.5) to win

-111
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.