Atlanta Falcons vs San Francisco 49ers Prediction & Picks - NFL
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by Bill Christy | in NFL Picks
San Francisco will head southeast to take on the Atlanta Falcons in the early slate of games on Sunday afternoon.
San Francisco, despite being hit hard by the injury bug, has been able to remain one of the 3 remaining undefeated teams in the NFL. Brock Purdy is in the early running for MVP while the defense is holding opponents to just 18.3 points per game, which is 4th in the league. Christian McCaffrey has been his consistent self and has the run game in the top 6 of the NFL. They are coming off a 23-17 victory over the Washington Commanders on Monday night. It took some mistakes by Washington for the Niners to put the game away, but a win is a win.
The Atlanta Falcons have also been dealing with some injuries to key players early in the season. They began the season losing their 1st two games, won the next two, and have since lost their last two. They have allowed an average of 30.5 points per game over their last 2 losses and have scored exactly 23 in each. Baltimore and Chicago are two strong teams but are arguably a level below this current 49ers team. They will need to get Bijan Robinson going early and often in this matchup.
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Atlanta Falcons vs San Francisco 49ers Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
2
|
1 | 6 | 6 | 0 |
|
20
|
0.333 | 6 | 2 | 4 |
Atlanta Falcons and San Francisco 49ers Latest Matches
2/6 (33%)
4/6 (67%)
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2/6 (33%)
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4/6 (67%)
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5/6 (83%)
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5/6 (83%)
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Atlanta Falcons against San Francisco 49ers : Head to Head (H2H)
0 %
100 %
Oct 19, 2025 - NFL
Atlanta Falcons - San Francisco 49ers Key Points
- Falcons are 4-0 ATS in their last 4 games after accumulating more than 250 yards passing in their previous game.
- Falcons are 3-2 ATS in their last 5 meetings.
- 49ers are 1-2 ATS in their last 3 games.
- 49ers are 0-2 ATS in their last 2 road games.
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Our Atlanta Falcons vs San Francisco 49ers Prediction
This spread makes no sense when looking at these teams on paper. The 6-0 49ers are less than a field-goal favorite against a Falcons team that is just 2-4? Not only that, but the public is betting them at an 80% clip. We love fading the public in this spot with a home dog that seems like they should be catching more than a touchdown on the spread. We would not be surprised if this Atlanta team wins this one outright.
Our prediction for Atlanta Falcons vs San Francisco 49ers: Atlanta +2.5
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
