Portland Trail Blazers vs San Antonio Spurs Prediction & Picks - NBA
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by Paul Tamayo | in NBA Picks
The San Antonio Spurs (11-5) visit the Portland Trail Blazers (8-10) in an NBA 2025-26 game on Wednesday, November 26, at the Moda Center.
The Blazers return home riding momentum after a 115-103 road win over the Milwaukee Bucks. Jerami Grant erupted for 35 points as Portland dominated from the free-throw line and knocked down 18 threes to finish a 2-1 road trip.
Portland continues to defy expectations this season, as they're sitting 9th in the stacked Western Conference. However, they're dealing with tons of injuries to their key players, including Jrue Holiday, Damian Lillard, Scoot Henderson, Shaedon Sharpe, and Matisse Thybulle.
As for the Spurs, they’ve cooled slightly after a hot start. San Antonio’s 11-5 record still has them near the top of the Western Conference, but they’re coming off a 111-102 road loss to the Phoenix Suns.
The Spurs built an early seven-point lead at halftime, but gave up 37 points to the Suns in the third quarter. De'Aaron Fox had a team-high 26 markers in the loss. Devin Vassell added 17, but he only shot 38.5% from the field.
San Antonio is also hampered by numerous injuries. They'll be missing the services of Victor Wembanyama, Stephon Castle, and Dylan Harper.
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Portland Trail Blazers vs San Antonio Spurs Form
Table
| Teams | % | P | W | L | Series |
|---|---|---|---|---|---|
|
2
|
0.756 | 82 | 62 | 20 | |
|
18
|
0.512 | 82 | 42 | 40 | 2 |
Portland Trail Blazers and San Antonio Spurs Latest Matches
2/6 (33%)
4/6 (67%)
Nov 24, 2025 - NBA
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3/6 (50%)
3/6 (50%)
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3/6 (50%)
3/6 (50%)
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3/6 (50%)
3/6 (50%)
Nov 23, 2025 - NBA
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4/6 (67%)
2/6 (33%)
Nov 20, 2025 - NBA
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3/6 (50%)
3/6 (50%)
Nov 23, 2025 - NBA
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Portland Trail Blazers against San Antonio Spurs : Head to Head (H2H)
33 %
67 %
Apr 6, 2025 - NBA
Dec 21, 2024 - NBA
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Players list
S. Cissoko
T. Camara
D. Avdija
J. Grant
J. Champagnie
D. Fox
H. Barnes
Substitutes
C. Love
S. Sharpe
D. Lillard
J. Holiday
K. Murray
D. Harper
L. Waters III
D. Jones
J. Sochan
R. Minix
C. Bryant
Portland Trail Blazers - San Antonio Spurs Key Points
- The Blazers are coming off a 115-103 win against the Milwaukee Bucks.
- The Spurs are coming off a 111-102 loss to the Phoenix Suns.
- The Blazers will miss the services of Jrue Holiday, Damian Lillard, Scoot Henderson, Shaedon Sharpe, and Matisse Thybulle.
- The Spurs will miss the services of Victor Wembanyama, Stephon Castle, and Dylan Harper.
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Our Portland Trail Blazers vs San Antonio Spurs Prediction
After a confidence-boosting road performance in Milwaukee, Portland now gets a short-handed Spurs team at home with massive NBA Cup stakes. San Antonio has been excellent overall, but without Victor Wembanyama’s rim protection and interior scoring, they lose their primary mismatch on both ends.
But don't expect the Blazers to run away with this game, as they're also dealing with a handful of injuries to their key players. Our prediction for the Portland Trail Blazers vs San Antonio Spurs match is: Spurs (+1.5) cover the spread.All tips are fully researched and given in good faith, but profits cannot be guaranteed.
