Philadelphia Eagles vs Tampa Bay Buccaneers Prediction & Picks - NFL

Prediction published on 9/28/25, 9:09 AM  by Erik Gibbs | Modified on 9/28/25 at 4:25 PM in NFL Picks

The Philadelphia Eagles and Tampa Bay Buccaneers will meet in Tampa on Sunday in what shapes up as one of the best early-season showdowns, with both clubs entering at 3-0. Each squad comes off a nail-biting win in Week 3, with Philadelphia edging the Rams 33-26 at home and Tampa Bay slipping past the Jets 29-27 on the road.

The Eagles have leaned on balance, ranking 29th in passing offense but 14th in rushing, while Tampa Bay has found success on the ground, sitting 7th in rushing offense but just 22nd in passing. Statistically, Philadelphia has the higher-ranked scoring offense, but both defenses have allowed more than 20 points per game, making this a potential shootout.

This game sets up as a test of Philadelphia’s ability to slow down an explosive Tampa Bay passing attack while keeping their own ground game in rhythm. The Eagles defense, middle-of-the-pack in scoring allowed, will need to step up to avoid getting carved apart by Mayfield and company. On the flip side, the Buccaneers defense has struggled to close out games, and against a team that thrives in late-game situations, that could be costly.