New England Patriots vs New Orleans Saints Prediction & Picks - NFL

USA - NFL

New England Patriots
10/12/25 13:00
New Orleans Saints

Prediction:

 

Saints to win

+155
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 by Simon Day in NFL Picks

The Saints and Patriots both enjoyed superb upset victories last weekend, so an exciting contest looks to be in store when the teams go head-to-head at the Superdome in Week 6 of the NFL season. 

New England completed a shock 23-20 road victory over the previously undefeated Buffalo Bills on Sunday night, thanks to a fantastic all-round performance, led by blossoming second-year QB Drake Maye. It's early days for new Pats HC Mike Vrabel, but the signs are extremely positive as he attempts to return the franchise to its past glories. 

The Saints' Week 5 victory was also down to an excellent all-round team effort that saw them overcome the Giants 26-14. After QB Spencer Rattler led the Saints to a narrow half time lead, the Saints' defence completely took over in the second half, shutting out the Giants and allowing Rattler to comfortably secure his first ever NFL victory. 

New England Patriots vs New Orleans Saints Form

Table

Teams % P W D L
10
New England Patriots
New England Patriots
0.6 5 3 0 2
29
New Orleans Saints
New Orleans Saints
0.2 5 1 0 4

New England Patriots and New Orleans Saints Latest Matches

New England Patriots
New England Patriots Latest matches
W L W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills

Sep 28, 2025 - NFL

Carolina Panthers
13 :  42
New England Patriots

Sep 21, 2025 - NFL

Pittsburgh Steelers
21 :  14
New England Patriots

Sep 14, 2025 - NFL

New England Patriots
33 :  27
Miami Dolphins

Sep 7, 2025 - NFL

Las Vegas Raiders
20 :  13
New England Patriots

Jan 5, 2025 - NFL

Buffalo Bills
16 :  23
New England Patriots
L L W L L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 28, 2025 - NFL

Carolina Panthers
13 :  42
New England Patriots

Sep 21, 2025 - NFL

Pittsburgh Steelers
21 :  14
New England Patriots

Sep 7, 2025 - NFL

Las Vegas Raiders
20 :  13
New England Patriots

Jan 5, 2025 - NFL

Buffalo Bills
16 :  23
New England Patriots

Dec 28, 2024 - NFL

Los Angeles Chargers
40 :  7
New England Patriots

Dec 1, 2024 - NFL

Indianapolis Colts
25 :  24
New England Patriots
W L L L W W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills

Sep 14, 2025 - NFL

New England Patriots
33 :  27
Miami Dolphins

Dec 22, 2024 - NFL

New England Patriots
21 :  24
Buffalo Bills

Dec 15, 2024 - NFL

New England Patriots
17 :  30
Arizona Cardinals

Nov 24, 2024 - NFL

New England Patriots
15 :  34
Miami Dolphins

Nov 10, 2024 - NFL

New England Patriots
19 :  3
Chicago Bears
New Orleans Saints
New Orleans Saints Latest matches
L L L L L W
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Oct 5, 2025 - NFL

New York Giants
14 :  26
New Orleans Saints

Sep 28, 2025 - NFL

New Orleans Saints
19 :  31
Buffalo Bills

Sep 21, 2025 - NFL

New Orleans Saints
13 :  44
Seattle Seahawks

Sep 14, 2025 - NFL

San Francisco 49ers
26 :  21
New Orleans Saints

Sep 7, 2025 - NFL

Arizona Cardinals
20 :  13
New Orleans Saints

Jan 5, 2025 - NFL

New Orleans Saints
19 :  27
Tampa Bay Buccaneers
L L L L L W
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Oct 5, 2025 - NFL

New York Giants
14 :  26
New Orleans Saints

Sep 14, 2025 - NFL

San Francisco 49ers
26 :  21
New Orleans Saints

Sep 7, 2025 - NFL

Arizona Cardinals
20 :  13
New Orleans Saints

Dec 29, 2024 - NFL

Las Vegas Raiders
25 :  10
New Orleans Saints

Dec 15, 2024 - NFL

Washington Commanders
20 :  19
New Orleans Saints

Dec 1, 2024 - NFL

Los Angeles Rams
21 :  14
New Orleans Saints
L W L L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 28, 2025 - NFL

New Orleans Saints
19 :  31
Buffalo Bills

Sep 21, 2025 - NFL

New Orleans Saints
13 :  44
Seattle Seahawks

Jan 5, 2025 - NFL

New Orleans Saints
19 :  27
Tampa Bay Buccaneers

Dec 23, 2024 - NFL

New Orleans Saints
0 :  34
Green Bay Packers

Dec 8, 2024 - NFL

New Orleans Saints
14 :  11
New York Giants

Nov 3, 2024 - NFL

New Orleans Saints
22 :  23
Carolina Panthers

New England Patriots against New Orleans Saints : Head to Head (H2H)

Oct 8, 2023 - NFL

New Orleans Saints
34 :  0
New England Patriots

New England Patriots - New Orleans Saints Key Points

  1. New England have the third worst red zone defence in the NFL this season
  2. The Saints have won their last 2 games against the Pats
  3. New Orleans have scored at least 20 points in each of their last 5 games against the Pats
  4. New England have not had a winning season since 2021

Our New England Patriots vs New Orleans Saints Prediction

The Patriots are clear favorites here, following their unexpectedly strong start to the season. However, we are backing the Saints to follow up their Week 5 victory with another home win. 

Spencer Rattler is quietly having a very efficient season behind center in New Orleans, and last weekend's victory will have given him a huge confidence boost.

The Pats are clearly the better overall side, but they are still struggling for consistency and are prone to having some seriously poor outings, such as the awful Week One defeat to the Raiders. 

Our prediction for New Orleans Saints vs New England Patriots is: Saints to win.

Prediction:

 

Saints to win

+155
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

New England Patriots vs New Orleans Saints Picks