Napoli vs Inter Milan Prediction & Picks - Serie A

Italy - Serie A

Napoli
10/25/25 12:00
Inter Milan

Prediction:

 

Inter to win

+145
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 by Simon Day in Serie A Picks

One of the biggest games of the Serie A season so far takes place on Saturday evening, as reigning league champions Napoli take on Inter Milan at the Stadio Diego Armando Maradona.

Both sides have picked up 15 points from their opening seven matches of the season and are just a point behind leaders AC Milan at the top of the Serie A table. However, with Milan facing a seemingly straightforwrd game against bottom side Pisa on Friday, both Inter and Napoli will be desperate to not lose any more ground in what looks like being a very tight title race. 

Remarkably, the last three competitive games between Napoli and Inter have all finished in 1-1 draws, a sequence that includes a thrilling contest towards the end of last season, in which a late Philip Billing strike secured a vital point for Napoli that maintained their advantage over Inter in the title race. 

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Napoli vs Inter Milan Form

Table

Teams Pts P W D L GD
2
Napoli
Napoli
31 14 10 1 3 10
3
Inter Milan
Inter Milan
30 14 10 0 4 19

Napoli and Inter Milan Latest Matches

Napoli
Napoli Latest matches
L W L W W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Average stats (Last 6 matchs)

3.83 Total goals
83% BTTS
1.67 Goals scored
2.17 Goals conceded
83% Over 2.5
17% Under 2.5

Oct 21, 2025 - Champions League

PSV Eindhoven
6 :  2
Napoli

Oct 18, 2025 - Serie A

Torino FC
1 :  0
Napoli

Oct 5, 2025 - Serie A

Napoli
2 :  1
Genoa

Oct 1, 2025 - Champions League

Napoli
2 :  1
Sporting Lisbon

Sep 28, 2025 - Serie A

AC Milan
2 :  1
Napoli

Sep 22, 2025 - Serie A

Napoli
3 :  2
Pisa SC
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Average stats (Last 6 matchs)

3.17 Total goals
67% BTTS
2.33 Goals scored
0.83 Goals conceded
83% Over 2.5
17% Under 2.5

Oct 5, 2025 - Serie A

Napoli
2 :  1
Genoa

Oct 1, 2025 - Champions League

Napoli
2 :  1
Sporting Lisbon

Sep 22, 2025 - Serie A

Napoli
3 :  2
Pisa SC

Aug 30, 2025 - Serie A

Napoli
1 :  0
Cagliari

Aug 14, 2025 - Clubs Friendlies

Napoli
2 :  1
Olympiacos

Aug 10, 2025 - Clubs Friendlies

Napoli
4 :  0
ASD Sorrento 1945
D W W L L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Average stats (Last 6 matchs)

3.33 Total goals
50% BTTS
1.33 Goals scored
2 Goals conceded
50% Over 2.5
50% Under 2.5

Oct 21, 2025 - Champions League

PSV Eindhoven
6 :  2
Napoli

Oct 18, 2025 - Serie A

Torino FC
1 :  0
Napoli

Sep 28, 2025 - Serie A

AC Milan
2 :  1
Napoli

Sep 18, 2025 - Champions League

Manchester City
2 :  0
Napoli

Sep 13, 2025 - Serie A

Fiorentina
1 :  3
Napoli

Aug 23, 2025 - Serie A

Sassuolo
0 :  2
Napoli
Inter Milan
Inter Milan Latest matches
W W W W D W
Victories

5/6 (83%)

Draw

1/6 (17%)

Defeats

0/6 (0%)

Average stats (Last 6 matchs)

2.83 Total goals
33% BTTS
2.5 Goals scored
0.33 Goals conceded
50% Over 2.5
50% Under 2.5

Oct 21, 2025 - Champions League

Union Saint-Gilloise
0 :  4
Inter Milan

Oct 18, 2025 - Serie A

Roma
0 :  1
Inter Milan

Oct 10, 2025 - Clubs Friendlies

Atletico Madrid
1 :  1
Inter Milan

Oct 4, 2025 - Serie A

Inter Milan
4 :  1
Cremonese

Sep 30, 2025 - Champions League

Inter Milan
3 :  0
Slavia Prague

Sep 27, 2025 - Serie A

Cagliari
0 :  2
Inter Milan
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Average stats (Last 6 matchs)

3.5 Total goals
50% BTTS
2.83 Goals scored
0.67 Goals conceded
83% Over 2.5
17% Under 2.5

Oct 4, 2025 - Serie A

Inter Milan
4 :  1
Cremonese

Sep 30, 2025 - Champions League

Inter Milan
3 :  0
Slavia Prague

Sep 21, 2025 - Serie A

Inter Milan
2 :  1
Sassuolo

Aug 31, 2025 - Serie A

Inter Milan
1 :  2
Udinese

Aug 25, 2025 - Serie A

Inter Milan
5 :  0
Torino FC

Aug 16, 2025 - Clubs Friendlies

Inter Milan
2 :  0
Olympiacos
D L W W D W
Victories

4/6 (67%)

Draw

1/6 (17%)

Defeats

1/6 (17%)

Average stats (Last 6 matchs)

3 Total goals
33% BTTS
2.17 Goals scored
0.83 Goals conceded
33% Over 2.5
67% Under 2.5

Oct 21, 2025 - Champions League

Union Saint-Gilloise
0 :  4
Inter Milan

Oct 18, 2025 - Serie A

Roma
0 :  1
Inter Milan

Oct 10, 2025 - Clubs Friendlies

Atletico Madrid
1 :  1
Inter Milan

Sep 27, 2025 - Serie A

Cagliari
0 :  2
Inter Milan

Sep 17, 2025 - Champions League

Ajax
0 :  2
Inter Milan

Sep 13, 2025 - Serie A

Juventus
4 :  3
Inter Milan

Napoli against Inter Milan : Head to Head (H2H)

Napoli

17 %

Draw

50 %

Inter Milan

33 %

Average stats (last H2H results)

2.33
Total goals
67%
BTTS
1
Goals scored (Team 1)
1.33
Goals scored (Team 2)
33%
Over 2.5
67%
Under 2.5

Mar 1, 2025 - Serie A

Napoli
1 :  1
Inter Milan

Nov 10, 2024 - Serie A

Inter Milan
1 :  1
Napoli

Mar 17, 2024 - Serie A

Inter Milan
1 :  1
Napoli

Jan 22, 2024 - Italian Super Cup

Napoli
0 :  1
Inter Milan

Dec 3, 2023 - Serie A

Napoli
0 :  3
Inter Milan

May 21, 2023 - Serie A

Napoli
3 :  1
Inter Milan

Napoli - Inter Milan: Form Analysis

It has been a terrible week for the Serie A champions, as a limp 1-0 league loss in Torino on Sunday was followed by a humiliating 6-2 thrashing by PSV in the Champions League, their second defeat in three games so far in the competition Those two losses have put a bit of pressure on Napoli boss Antonio Conte, especially as his side's overall displays this season have been below the extremely high standards of the last campaign. 

Inter on fire

Inter come into Saturday's contest in fantastic form, having won their last seven games. Their most recent victory was a comprehensive 0-4 success at Union SG in the Champions League, a result that maintained Inter's 100% record in the competition. A rock-solid defence has been the key to success for Cristian Chivu's side. Since losing 4-3 to Juve in early September, Inter have conceded just two goals in their seven subsequent matches. 

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Napoli against Inter Milan Lineups: Starting 11

Napoli

Formation : 4 - 1 - 4 - 1

32
V. Milinkovic-Savic
22
G. Di Lorenzo
4
A. Buongiorno
5
J. Jesus
37
L. Spinazzola
6
B. Gilmour
21
M. Politano
99
F. Anguissa
11
K. De Bruyne
8
S. Mctominay
7
D. Neres
10
L. Martinez
14
A. Bonny
32
F. Dimarco
22
H. Mkhitaryan
20
H. Calhanoglu
23
N. Barella
2
D. Dumfries
95
A. Bastoni
15
F. Acerbi
25
M. Akanji
1
Y. Sommer

Formation : 3 - 5 - 2

Inter Milan

Missing players

Napoli
Napoli
Goalkeeper

N. Contini

Defender

A. Rrahmani

Midfielder

L. Hasa

C. Saco

S. Lobotka

Forward

R. Lukaku

R. Hojlund

Inter Milan
Inter Milan
Goalkeeper

R. Di Gennaro

Defender

M. Darmian

Forward

M. Thuram

Napoli & Inter Milan Squad Analysis

Napoli are hopeful that striker Rasmus Højlundl will be fit for Saturday's game, having missed the defeat at PSV due to a minor muscle problem. The Danish striker has made a hugely encouraging start to life in Naples, and has provided a more-than-capable replacement for long term injury absentee Romelu Lukaku. The only other injury absentee for Antonio Conte's side will be midfielder Stanislav Lobotka, who is still recovering from an abductor injury that has kept him out for the last two months. 

Thuram to miss out

Inter will also go into Saturday's game without a key forward, as French frontman Marcus Thuram continues to recover from the hamstring injury he suffered last week. Full back Matteo Darmian also misses out due to an ongoing calf problem, but aside from that, Christian Chivu will have a full strength squad to choose from. 

Most goals and assists

CD Huachipato Napoli
CD Huachipato Inter Milan
Top Goalscorer
Denmark R. Hojlund (6 Goals)
Top Goalscorer
Argentina L. Martinez (11 Goals)
Best assists
Brazil D. Neres (4 Assists)
Best assists
Italy F. Dimarco (6 Assists)

Napoli - Inter Milan Key Points

  1. Inter are on a 7 game winning run
  2. Napoli have lost 3 of their last 5 games in all competitions
  3. Inter are unbeaten in their last 5 games against Napoli
  4. Inter have conceded just twice in their last 6 games
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Our Napoli vs Inter Milan Prediction

We're going with the formmbook in this one. Simply put, Inter are in far better form than Napoli so we are tipping the away side to win. 

Napoli have looked woefully short of their best in their last two matches, and given the fact that Inter are a vastly suerior team to both Torino and PSV, it is hard to see Conte's team getting anything from Saturday's game. 

Inter are very slight favorites with the bookies, but we still think their odds of 2.45 represent excellent value. 

Our prediction for Napoli vs Inter Milan is: Inter to win. 

Prediction:

 

Inter to win

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Napoli vs Inter Milan - Other Interesting Picks

Lautaro Martínez first goalscorer

Odds +400

Lautaro Martínez has become one of the best strikers in the world over the last 2-3 seasons, and he has begun this campaign in excellent form. The Argentinian World Cup winner has scored in four of his previous five games, and given Napoli's woeful defensive effort in the Netherlands, we think there is an excellent chance that Martinez opens the scoring on Saturday. 

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Napoli vs Inter Milan match : Frequently asked questions

The Napoli vs Inter Milan Serie A game kicks off at 18:00 CET on Saturday October 25th.
The Napoli vs Inter Milan game is taking place at the Stadio Diego Armando Maradona in Naples.

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Napoli vs Inter Milan Picks