Iowa Hawkeyes vs Iowa State Cyclones Prediction & Picks - NCAA

USA - NCAA

Iowa Hawkeyes
9/12/26 19:30
Iowa State Cyclones

Prediction:

 

Iowa State Cyclones +14.5 Alternate Spread

-125
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 by Matt Lowrimore | in NCAA Picks

One of the games on the Week 2 College Football Saturday slate will be a rivalry game between the Iowa State Cyclones and the Iowa Hawkeyes. Let’s take a look at the match statistics and predictions for this game between the Cyclones and the Hawkeyes.

Iowa State enters this game with a record of 1-0, beating SE Missouri in Week 1 by a score of 38-10. The Cyclones dominated this game, but had just 303 yards of offense. That said, they allowed just 209 yards to SE Missouri. More importantly, Iowa State forced three turnovers, which suggests they will be able to have the same success against Iowa, who is known for being inconsistent offensively.

As for Iowa, they also enter this game with a record of 1-0, beating Northern Illinois by a score of 40-0 in Week 1. For once, the Hawkeyes played a complete game, racking up over 500 yards of offense, while allowing just 120 yards. As good as the Hawkeyes played, they are still known for being inconsistent offensively, which is what seems likely in this matchup.

Iowa Hawkeyes vs Iowa State Cyclones Form

Iowa Hawkeyes and Iowa State Cyclones Latest Matches

Iowa Hawkeyes
Iowa Hawkeyes Latest matches
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 5, 2026 - NCAA

Iowa Hawkeyes
40 :  0
Northern Illinois Huskies

Dec 31, 2025 - NCAA Division I, FBS, Playoffs

Vanderbilt Commodores
27 :  34
Iowa Hawkeyes

Nov 28, 2025 - NCAA

Nebraska Cornhuskers
16 :  40
Iowa Hawkeyes

Nov 22, 2025 - NCAA

Iowa Hawkeyes
20 :  17
Michigan State Spartans

Nov 15, 2025 - NCAA

USC Trojans
26 :  21
Iowa Hawkeyes

Nov 8, 2025 - NCAA

Iowa Hawkeyes
16 :  18
Oregon Ducks
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 5, 2026 - NCAA

Iowa Hawkeyes
40 :  0
Northern Illinois Huskies

Nov 22, 2025 - NCAA

Iowa Hawkeyes
20 :  17
Michigan State Spartans

Nov 8, 2025 - NCAA

Iowa Hawkeyes
16 :  18
Oregon Ducks

Oct 25, 2025 - NCAA

Iowa Hawkeyes
41 :  3
Minnesota Golden Gophers

Oct 18, 2025 - NCAA

Iowa Hawkeyes
25 :  24
Penn State Nittany Lions

Sep 27, 2025 - NCAA

Iowa Hawkeyes
15 :  20
Indiana Hoosiers
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 31, 2025 - NCAA Division I, FBS, Playoffs

Vanderbilt Commodores
27 :  34
Iowa Hawkeyes

Nov 28, 2025 - NCAA

Nebraska Cornhuskers
16 :  40
Iowa Hawkeyes

Nov 15, 2025 - NCAA

USC Trojans
26 :  21
Iowa Hawkeyes

Oct 11, 2025 - NCAA

Wisconsin Badgers
0 :  37
Iowa Hawkeyes

Sep 19, 2025 - NCAA

Rutgers Scarlet Knights
28 :  38
Iowa Hawkeyes

Sep 6, 2025 - NCAA

Iowa State Cyclones
16 :  13
Iowa Hawkeyes
Iowa State Cyclones
Iowa State Cyclones Latest matches
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 5, 2026 - NCAA

Iowa State Cyclones
38 :  10
Southeast Missouri State Redhawks

Nov 29, 2025 - NCAA

Oklahoma State Cowboys
13 :  20
Iowa State Cyclones

Nov 22, 2025 - NCAA

Iowa State Cyclones
38 :  14
Kansas Jayhawks

Nov 8, 2025 - NCAA

TCU Horned Frogs
17 :  20
Iowa State Cyclones

Nov 1, 2025 - NCAA

Iowa State Cyclones
19 :  24
Arizona State Sun Devils

Oct 25, 2025 - NCAA

Iowa State Cyclones
27 :  41
BYU Cougars
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 5, 2026 - NCAA

Iowa State Cyclones
38 :  10
Southeast Missouri State Redhawks

Nov 22, 2025 - NCAA

Iowa State Cyclones
38 :  14
Kansas Jayhawks

Nov 1, 2025 - NCAA

Iowa State Cyclones
19 :  24
Arizona State Sun Devils

Oct 25, 2025 - NCAA

Iowa State Cyclones
27 :  41
BYU Cougars

Sep 27, 2025 - NCAA

Iowa State Cyclones
39 :  14
Arizona Wildcats

Sep 6, 2025 - NCAA

Iowa State Cyclones
16 :  13
Iowa Hawkeyes
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 29, 2025 - NCAA

Oklahoma State Cowboys
13 :  20
Iowa State Cyclones

Nov 8, 2025 - NCAA

TCU Horned Frogs
17 :  20
Iowa State Cyclones

Oct 11, 2025 - NCAA

Colorado Buffaloes
24 :  17
Iowa State Cyclones

Oct 4, 2025 - NCAA

Cincinnati Bearcats
38 :  30
Iowa State Cyclones

Sep 13, 2025 - NCAA

Arkansas State Red Wolves
16 :  24
Iowa State Cyclones

Aug 23, 2025 - NCAA

Kansas State Wildcats
21 :  24
Iowa State Cyclones

Iowa Hawkeyes against Iowa State Cyclones : Head to Head (H2H)

Iowa Hawkeyes

0 %

Iowa State Cyclones

100 %

Sep 6, 2025 - NCAA

Iowa State Cyclones
16 :  13
Iowa Hawkeyes
Iowa Hawkeyes vs Iowa State Cyclones Picks

Iowa Hawkeyes - Iowa State Cyclones Key Points

  1. Iowa is 0-2 SU vs Iowa State in the last 2 meetings
  2. The Under is 2-0 in the last 2 meetings
  3. Iowa is 1-0 ATS this season
  4. Iowa State is 0-1 ATS this season

Our Iowa Hawkeyes vs Iowa State Cyclones Prediction

Iowa is a two-touchdown favorite in this game; however, Iowa State looks to be the best betting option. Even though the Cyclones did not completely dominate SE Missouri, they usually play Iowa extremely tight. In fact, Iowa State has won the last two meetings with Iowa straight up. 

Further, these last two meetings were determined by a total of four points. Ultimately, the Hawkeyes could snap their losing streak to the Cyclones, but with this game being a rivalry, we expect it to be tight as it has been in recent years. For that reason, our Iowa State Cyclones vs Iowa Hawkeyes prediction is: Iowa State Cyclones +14.5 Alternate Spread.

Prediction:

 

Iowa State Cyclones +14.5 Alternate Spread

-125
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.