Cleveland Cavaliers vs Indiana Pacers Prediction & Picks - NBA
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by Paul Tamayo in NBA Picks
The Indiana Pacers (2-13) visit the Cleveland Cavaliers (10-6) in an NBA 2025-26 game on Friday, November 21, at Rocket Arena.
The Cavaliers look to protect home court and strengthen their NBA Cup group-stage position when they host the Pacers on Friday. They recently had their momentum halted in a physical 114-104 home loss to the Houston Rockets.
Cleveland fell behind big early, trimmed the gap to a single point in the fourth quarter, but couldn’t complete the comeback as Houston answered with a decisive late run. De'Andre Hunter had a good game despite the loss, leading the Cavaliers in scoring with 25. Donovan Mitchell and Evan Mobley chipped in 21 and 18 points, respectively.
As for the Pacers, they finally snapped an eight-game losing skid with a 127-118 home win over the Charlotte Hornets. Bennedict Mathurin led the way with 24 points and 12 rebounds, Pascal Siakam contributed 22 points and seven assists, and Jay Huff delivered 20 points off the bench.
However, the Pacers are still battling injuries to their key players, including Tyrese Haliburton, Obi Toppin, and Aaron Nesmith.
On the other end, the Cavaliers list Darius Garland, Sam Merrill, and Max Strus as out for Friday's game.
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Cleveland Cavaliers vs Indiana Pacers Form
Table
| Teams | % | P | W | L | Series |
|---|---|---|---|---|---|
|
13
|
0.558 | 43 | 24 | 19 | 2 |
|
29
|
0.238 | 42 | 10 | 32 | 1 |
Cleveland Cavaliers and Indiana Pacers Latest Matches
4/6 (67%)
2/6 (33%)
Nov 21, 2025 - NBA
Nov 19, 2025 - NBA
Nov 17, 2025 - NBA
Nov 15, 2025 - NBA
Nov 13, 2025 - NBA
Nov 12, 2025 - NBA
4/6 (67%)
2/6 (33%)
Nov 21, 2025 - NBA
Nov 19, 2025 - NBA
Nov 17, 2025 - NBA
Nov 15, 2025 - NBA
Nov 13, 2025 - NBA
Nov 8, 2025 - NBA
4/6 (67%)
2/6 (33%)
Nov 12, 2025 - NBA
Nov 10, 2025 - NBA
Nov 7, 2025 - NBA
Oct 29, 2025 - NBA
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Oct 24, 2025 - NBA
1/6 (17%)
5/6 (83%)
Nov 21, 2025 - NBA
Nov 19, 2025 - NBA
Nov 17, 2025 - NBA
Nov 15, 2025 - NBA
Nov 13, 2025 - NBA
Nov 11, 2025 - NBA
2/6 (33%)
4/6 (67%)
Nov 19, 2025 - NBA
Nov 15, 2025 - NBA
Nov 5, 2025 - NBA
Nov 3, 2025 - NBA
Nov 1, 2025 - NBA
Oct 31, 2025 - NBA
0/6 (0%)
6/6 (100%)
Nov 21, 2025 - NBA
Nov 17, 2025 - NBA
Nov 13, 2025 - NBA
Nov 11, 2025 - NBA
Nov 9, 2025 - NBA
Nov 8, 2025 - NBA
Cleveland Cavaliers against Indiana Pacers : Head to Head (H2H)
33 %
67 %
Nov 21, 2025 - NBA
Jul 10, 2025 - NBA Summer League
May 13, 2025 - NBA
May 11, 2025 - NBA
May 9, 2025 - NBA
May 6, 2025 - NBA
Players list
D. Mitchell
D. Garland
ForwardE. Mobley
J. Tyson
B. Mathurin
B. Sheppard
A. Nembhard
ForwardI. Jackson
P. Siakam
Substitutes
C. Porter
L. Ball
T. Proctor
ForwardN. Tomlin
G. Mathews
R. Dennis
T. Peter
T. McConnell
ForwardJ. Walker
Cleveland Cavaliers - Indiana Pacers Key Points
- The Cavaliers are coming off a 114-104 home loss to the Houston Rockets.
- The Pacers are coming off a 127-118 win over the Charlotte Hornets.
- The Cavaliers will miss the services of Darius Garland, Sam Merrill, and Max Strus.
- The Pacers will miss the services of Tyrese Haliburton, Obi Toppin, and Aaron Nesmith.
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Our Cleveland Cavaliers vs Indiana Pacers Prediction
Despite the Pacers’ morale-boosting win over the Hornets, they’ve still dropped 13 of their first 15 games. They are leaning heavily on Bennedict Mathurin and Pascal Siakam to carry an injury-depleted roster.
Things haven't been smooth for the Cavaliers, either. They've lost two of their last four games, but look for them to take advantage and run up the score against a team with one of the worst records in the league. Our prediction for the Cleveland Cavaliers vs Indiana Pacers match is: Cavaliers (-13.5) cover the spread.Grab an extra $300 for your Cleveland Cavaliers vs Indiana Pacers wager!
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
