Indiana Hoosiers vs Ohio State Buckeyes Prediction & Picks - NCAA

USA - NCAA

Indiana Hoosiers
12/6/25 20:00
Ohio State Buckeyes

Prediction:

 

Indiana Hoosiers +4

-110
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 by Matt Lowrimore in NCAA Picks

Perhaps the most anticipated Conference Championship game will see the 2nd-ranked Indiana Hoosiers take on the 1st-ranked Ohio State Buckeyes. Let’s take a look at the match statistics and predictions for this game between the Hoosiers and the Buckeyes.

Indiana enters this game with a record of 12-0 and finished the regular season 9-0 in the Big Ten. The Hoosiers most recently beat the Purdue Boilermakers in Week 14 by a score of 56-3. Indiana’s offense had a total of 548 yards, while its defense allowed 282 yards. Quarterback Fernando Mendoza threw for 117 yards and two touchdowns, while running back Roman Hemby led the team in rushing with 152 yards and one touchdown.

As for Ohio State, they enter this game with a record of 12-0 and also finished the regular season 9-0 in the Big Ten. The Buckeyes most recently beat the Michigan Wolverines in Week 14 by a score of 27-9. Ohio State’s offense had a total of 419 yards, while its defense allowed 163 yards. Quarterback Julian Sayin threw for 233 yards, three touchdowns, and one interception, while running back Bo Jackson led the team in rushing with 117 yards.

Indiana Hoosiers vs Ohio State Buckeyes Form

Indiana Hoosiers and Ohio State Buckeyes Latest Matches

Indiana Hoosiers
Indiana Hoosiers Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 28, 2025 - NCAA

Indiana Hoosiers
56 :  3
Purdue Boilermakers

Nov 15, 2025 - NCAA

Wisconsin Badgers
7 :  31
Indiana Hoosiers

Nov 8, 2025 - NCAA

Indiana Hoosiers
27 :  24
Penn State Nittany Lions

Nov 1, 2025 - NCAA

Indiana Hoosiers
55 :  10
Maryland Terrapins

Oct 25, 2025 - NCAA

UCLA Bruins
6 :  56
Indiana Hoosiers

Oct 18, 2025 - NCAA

Michigan State Spartans
13 :  38
Indiana Hoosiers
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 15, 2025 - NCAA

Wisconsin Badgers
7 :  31
Indiana Hoosiers

Oct 25, 2025 - NCAA

UCLA Bruins
6 :  56
Indiana Hoosiers

Oct 18, 2025 - NCAA

Michigan State Spartans
13 :  38
Indiana Hoosiers

Sep 20, 2025 - NCAA

Illinois Fighting Illini
10 :  63
Indiana Hoosiers

Sep 12, 2025 - NCAA

Indiana State Sycamores
0 :  73
Indiana Hoosiers

Sep 6, 2025 - NCAA

Kennesaw State Owls
9 :  56
Indiana Hoosiers
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 28, 2025 - NCAA

Indiana Hoosiers
56 :  3
Purdue Boilermakers

Nov 8, 2025 - NCAA

Indiana Hoosiers
27 :  24
Penn State Nittany Lions

Nov 1, 2025 - NCAA

Indiana Hoosiers
55 :  10
Maryland Terrapins

Oct 11, 2025 - NCAA

Indiana Hoosiers
30 :  20
Oregon Ducks

Sep 27, 2025 - NCAA

Indiana Hoosiers
20 :  15
Iowa Hawkeyes

Dec 20, 2024 - NCAA

Indiana Hoosiers
17 :  27
Notre Dame Fighting Irish
Ohio State Buckeyes
Ohio State Buckeyes Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 29, 2025 - NCAA

Ohio State Buckeyes
27 :  9
Michigan Wolverines

Nov 22, 2025 - NCAA

Rutgers Scarlet Knights
9 :  42
Ohio State Buckeyes

Nov 15, 2025 - NCAA

UCLA Bruins
10 :  48
Ohio State Buckeyes

Nov 8, 2025 - NCAA

Ohio State Buckeyes
34 :  10
Purdue Boilermakers

Nov 1, 2025 - NCAA

Penn State Nittany Lions
14 :  38
Ohio State Buckeyes

Oct 18, 2025 - NCAA

Ohio State Buckeyes
34 :  0
Wisconsin Badgers
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 22, 2025 - NCAA

Rutgers Scarlet Knights
9 :  42
Ohio State Buckeyes

Nov 15, 2025 - NCAA

UCLA Bruins
10 :  48
Ohio State Buckeyes

Nov 1, 2025 - NCAA

Penn State Nittany Lions
14 :  38
Ohio State Buckeyes

Oct 4, 2025 - NCAA

Minnesota Golden Gophers
3 :  42
Ohio State Buckeyes

Sep 13, 2025 - NCAA

Ohio Bobcats
9 :  37
Ohio State Buckeyes

Sep 6, 2025 - NCAA

Grambling State Tigers
0 :  70
Ohio State Buckeyes
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 29, 2025 - NCAA

Ohio State Buckeyes
27 :  9
Michigan Wolverines

Nov 8, 2025 - NCAA

Ohio State Buckeyes
34 :  10
Purdue Boilermakers

Oct 18, 2025 - NCAA

Ohio State Buckeyes
34 :  0
Wisconsin Badgers

Oct 11, 2025 - NCAA

Ohio State Buckeyes
34 :  16
Illinois Fighting Illini

Sep 27, 2025 - NCAA

Ohio State Buckeyes
24 :  6
Washington Huskies

Jan 20, 2025 - NCAA

Ohio State Buckeyes
34 :  23
Notre Dame Fighting Irish

Indiana Hoosiers - Ohio State Buckeyes Key Points

  1. Indiana is allowing 12.0 points per game vs the Big Ten
  2. Indiana is averaging 41.8 points per game vs the Big Ten
  3. Ohio State is allowing 8.5 points per game vs the Big Ten
  4. Ohio State is averaging 35.8 points per game vs the Big Ten

Our Indiana Hoosiers vs Ohio State Buckeyes Prediction

Ohio State is the small favorite to win the Big Ten Championship; however, Indiana looks to be the best betting option to keep this game close. The Buckeyes have been dominant all season, averaging 35.8 points per game against Big Ten opponents. More importantly, their defense is allowing just 8.5 points per game against Big Ten opponents. 

If any team is going to score on Ohio State, Indiana looks to be the best candidate. The Hoosiers are averaging nearly 42 points per game against Big Ten opponents, while their defense is allowing an average of 12 points per game.

It is also worth noting that Ohio State’s Offensive Coordinator, Brian Hartline, just accepted a Head Coaching job at South Florida. This likely means he will not be calling the plays in this Championship game, and could have a negative effect on the Buckeyes’ game plan. 

Because these teams look to be evenly matched, our Indiana Hoosiers vs Ohio State Buckeyes prediction is: Indiana Hoosiers +4.

Prediction:

 

Indiana Hoosiers +4

-110
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Indiana Hoosiers vs Ohio State Buckeyes Picks