Chicago White Sox vs Cleveland Guardians Prediction & Picks - MLB
USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Carlos Zabala in MLB Picks
The Guardians were reeling from losing the first two games of the divisional playoff series at home in Progressive Field to the White Sox, but on Wednesday they faced the elimination game in Chicago with determination, staying alive with a 9-3 victory.
"We keep plie on," Vogt said, referring to the runs they drove in during Game 3. Cleveland showed resilience, starting the game down and losing their starter, Espino, after recording only two outs. But the bullpen battled back; six relievers were used, with Griffin getting the win and the reliable Cade Smith pitching the final two innings, racking up an impressive 19 strikeouts.
The loss was a wake-up call for White Sox fans who had already envisioned the Guards being eliminated, but 11 hits, an RBI triple by Adell, and another RBI triple by Ramírez proved decisive. Now the series looks more alive than ever.
Limited Offer. Currently at DraftKings
Chicago White Sox vs Cleveland Guardians Form
Chicago White Sox and Cleveland Guardians Latest Matches
5/6 (83%)
1/6 (17%)
Oct 7, 2026 - MLB
Oct 5, 2026 - MLB
Oct 3, 2026 - MLB
Sep 30, 2026 - MLB
Sep 29, 2026 - MLB
Sep 27, 2026 - MLB
4/6 (67%)
2/6 (33%)
Oct 7, 2026 - MLB
Sep 27, 2026 - MLB
Sep 26, 2026 - MLB
Sep 25, 2026 - MLB
Sep 20, 2026 - MLB
Sep 19, 2026 - MLB
5/6 (83%)
1/6 (17%)
Oct 5, 2026 - MLB
Oct 3, 2026 - MLB
Sep 30, 2026 - MLB
Sep 29, 2026 - MLB
Sep 24, 2026 - MLB
Sep 23, 2026 - MLB
3/6 (50%)
3/6 (50%)
Oct 7, 2026 - MLB
Oct 5, 2026 - MLB
Oct 3, 2026 - MLB
Sep 27, 2026 - MLB
Sep 26, 2026 - MLB
Sep 25, 2026 - MLB
4/6 (67%)
2/6 (33%)
Oct 5, 2026 - MLB
Oct 3, 2026 - MLB
Sep 20, 2026 - MLB
Sep 19, 2026 - MLB
Sep 18, 2026 - MLB
Sep 16, 2026 - MLB
4/6 (67%)
2/6 (33%)
Oct 7, 2026 - MLB
Sep 27, 2026 - MLB
Sep 26, 2026 - MLB
Sep 25, 2026 - MLB
Sep 24, 2026 - MLB
Sep 23, 2026 - MLB
Chicago White Sox against Cleveland Guardians : Head to Head (H2H)
50 %
50 %
Oct 7, 2026 - MLB
Oct 5, 2026 - MLB
Oct 3, 2026 - MLB
Sep 16, 2026 - MLB
Sep 15, 2026 - MLB
Sep 14, 2026 - MLB
Chicago White Sox - Cleveland Guardians Key Points
- On Wednesday, no White Sox player recorded a multi-hit game
- Cleveland last reached the World Series in 2016; the White Sox, in 2005
- Guardians have a 44-37 road record this season
- The White Sox have a 33-19 record against divisional rivals this season
Limited Offer. Currently at DraftKings
Our Chicago White Sox vs Cleveland Guardians Prediction
The series, in which only visiting teams have won, continues at Rate Field; After Wednesday's offensive explosion, in which Ramirez, Adell, Bailey, and Rocchio all recorded a multi-hit game for the Guards, Cleveland now appears as a slight favorite in the pregame odds to take Game 4.
Parker Messick will start for the Guardians in the first game of the series, pitching 4.1 innings with two earned runs and striking out six. Even if they win the series, the White Sox are struggling with strikeouts, having recorded 10, 13, and 19 strikeouts in Games 1, 2, and 3, respectively.
Our prediction for White Sox vs Guardians is: Guardians ML.
A Welcome Bonus for Chicago White Sox vs Cleveland Guardians!
Looking to place a bet on Chicago White Sox vs Cleveland Guardians? For this MLB match, DraftKings will treat you to an exclusive offer: $150 in bonus bets, no promo code needed! Take advantage while you still can!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
